Results 61 to 70 of about 10,170,244 (414)

Potent SARS-CoV-2 binding and neutralization through maturation of iconic SARS-CoV-1 antibodies

mAbs, 2021
Antibodies against coronavirus spike protein potently protect against infection and disease, but whether such protection can be extended to variant coronaviruses is unclear.
Romain Rouet, Ohan Mazigi, Gregory J. Walker, David B. Langley, Meghna Sobti, Peter Schofield, Helen Lenthall, Jennifer Jackson, Stephanie Ubiparipovic, Jake Y. Henry, Arunasingam Abayasingam, Deborah Burnett, Anthony Kelleher, Robert Brink, Rowena A. Bull, Stuart Turville, Alastair G. Stewart, Christopher C. Goodnow, William D. Rawlinson, Daniel Christ   +19 more
doaj   +1 more source

Antibodies for immunolabeling by light and electron microscopy : not for the faint hearted [PDF]

, 2014
Reliable antibodies represent crucial tools in the arsenal of the cell biologist and using them to localize antigens for immunocytochemistry is one of their most important applications.
Griffiths, Gareth, Lucocq, John Milton
core   +1 more source

Net charge of antibody complementarity-determining regions is a key predictor of specificity.

Protein engineering, design & selection : PEDS, 2018
Specificity is one of the most important and complex properties that is central to both natural antibody function and therapeutic antibody efficacy.
Lilia A. Rabia, Yulei Zhang, Seth D. Ludwig, Mark C. Julian, P. Tessier   +4 more
semanticscholar   +1 more source

Defining the features and duration of antibody responses to SARS-CoV-2 infection associated with disease severity and outcome

Science immunology, 2020
Illness severity in COVID-19 correlates with specificity of serological responses, but antibody levels decrease in most patients. SARS-CoV-2-specific antibodies, particularly those preventing viral spike receptor binding domain (RBD) interaction with ...
K. Röltgen, Abigail E. Powell, O. Wirz, Bryan A. Stevens, C. Hogan, J. Najeeb, Molly Hunter, Hannah Wang, M. Sahoo, ChunHong Huang, F. Yamamoto, M. Manohar, Justin Manalac, A. R. Otrelo-Cardoso, T. Pham, A. Rustagi, A. Rogers, N. Shah, C. Blish, J. Cochran, T. Jardetzky, J. Zehnder, Taia T. Wang, B. Narasimhan, S. Gombar, R. Tibshirani, K. Nadeau, P. Kim, B. Pinsky, S. Boyd   +29 more
semanticscholar   +1 more source

xTrimoABFold: De novo Antibody Structure Prediction without MSA [PDF]

arXiv, 2022
In the field of antibody engineering, an essential task is to design a novel antibody whose paratopes bind to a specific antigen with correct epitopes. Understanding antibody structure and its paratope can facilitate a mechanistic understanding of its function.
arxiv  

Cell-type specific potent Wnt signaling blockade by bispecific antibody. [PDF]

, 2018
Cell signaling pathways are often shared between normal and diseased cells. How to achieve cell type-specific, potent inhibition of signaling pathways is a major challenge with implications for therapeutic development.
Bidlingmaier, Scott, Ha, Kevin D, Lee, Nam-Kyung, Liu, Bin, Sherbenou, Daniel W, Su, Yang, Zhang, Yafeng   +6 more
core   +2 more sources

Epitope specificity plays a critical role in regulating antibody-dependent cell-mediated cytotoxicity against influenza A virus

Proceedings of the National Academy of Sciences of the United States of America, 2016
Significance In addition to neutralizing antigens, antibodies are also capable of stimulating cellular responses through Fc–Fc receptor interactions.
Wenqian He, G. Tan, Caitlin E. Mullarkey, Amanda J. Lee, M. Lam, F. Krammer, Carole J Henry, P. Wilson, A. Ashkar, P. Palese, Matthew S. Miller   +10 more
semanticscholar   +1 more source

Species- and organ-specificity of secretory proteins derived from human prostate and seminal vesicles [PDF]

, 1990
Polyclonal antibodies against semenogelin (SG) isolated from human seminal vesicle secretion and acid phosphatase (PAP), β‐microseminoprotein (β‐MSP), and Prostate‐Specific Antigen (PSA) derived from human prostatic fluid, as well as a monoclonal ...
Abrahamsson, P., Aumuller, G., Lilja, H., Scheit, K., Seitz, J., von der Kammer, H.   +5 more
core   +2 more sources

Arginine mutations in antibody complementarity-determining regions display context-dependent affinity/specificity trade-offs

Journal of Biological Chemistry, 2017
Antibodies commonly accumulate charged mutations in their complementarity-determining regions (CDRs) during affinity maturation to enhance electrostatic interactions.
K. Tiller, Lijuan Li, Sandeep Kumar, Mark C. Julian, S. Garde, P. Tessier   +5 more
semanticscholar   +1 more source

Insights into PI3K/AKT signaling in B cell development and chronic lymphocytic leukemia

FEBS Letters, EarlyView.
This Review explores how the phosphoinositide 3‐kinase and protein kinase B pathway shapes B cell development and drives chronic lymphocytic leukemia, a common blood cancer. It examines how signaling levels affect disease progression, addresses treatment challenges, and introduces novel experimental strategies to improve therapies and patient outcomes.
Maike Buchner
wiley   +1 more source