Results 71 to 80 of about 10,170,244 (414)

Limited Specificity of Serologic Tests for SARS-CoV-2 Antibody Detection, Benin

Emerging Infectious Diseases, 2021
We used commercially available ELISAs to test 68 samples from coronavirus disease cases and prepandemic controls from Benin. We noted
Anges Yadouleton, Anna-Lena Sander, Andres Moreira-Soto, Carine Tchibozo, Gildas Hounkanrin, Yvette Badou, Carlo Fischer, Nina Krause, Petas Akogbeto, Edmilson F. de Oliveira Filho, Anges Dossou, Sebastian Brünink, Melchior A. Joël Aïssi, Mamoudou Harouna Djingarey, Benjamin Hounkpatin, Michael Nagel, Jan Felix Drexler   +16 more
doaj   +1 more source

A serological investigation of caseous lymphadenitis in four flocks of sheep [PDF]

, 2006
A double antibody sandwich ELISA developed by ID-DLO, Lelystad to detect Corynebocterium pseudotuberculosis infection was used on 329 sheep from four pedigree Suffolk flocks in which clinical cases of caseous lymphadenitis (CLA) had occurred.
Baird, Graham J., Fee, Seán A., Kamp, Elbarte M., King, David C., Malone, Frank (Frank E.), Murdock, Fiona E. A., O'Reilly, Kath M.   +6 more
core   +6 more sources

Diphthamide synthesis is linked to the eEF2‐client chaperone machinery

FEBS Letters, EarlyView.
The diphthamide modification of eukaryotic translation elongation factor 2 (eEF2) is important for accurate protein synthesis. We addressed the potential coordination of de novo eEF2 synthesis with simultaneous or subsequent diphthamide modification. Our work reveals that the co‐chaperones Hgh1 and Cpr7, which are known to support folding of nascent ...
Lars Kaduhr, Klaus Mayer, Raffael Schaffrath, Johannes Buchner, Ulrich Brinkmann   +4 more
wiley   +1 more source

Incorporating Pre-training Paradigm for Antibody Sequence-Structure Co-design [PDF]

arXiv, 2022
Antibodies are versatile proteins that can bind to pathogens and provide effective protection for human body. Recently, deep learning-based computational antibody design has attracted popular attention since it automatically mines the antibody patterns from data that could be complementary to human experiences.
arxiv  

Autoantibodies against retinal proteins in paraneoplastic and autoimmune retinopathy [PDF]

, 2004
BACKGROUND: Autoimmune retinal degeneration may occur in patients who present with sudden or, less commonly, subacute loss of vision of retinal origin, associated with an abnormal ERG, through the action of autoantibodies against retinal proteins.
AH Milam, B Lei, CE Thirkill, DM Jacobson, G Adamus, G Adamus, G Adamus, G Adamus, G Adamus, G Adamus, G Adamus, G Ren, G Tezel, Gaoying Ren, Grazyna Adamus, H Ohguro, H Ohguro, I Maruyama, JB Mizener, JL Keltner, JL Keltner, JL Keltner, JR Heckenlively, MA Murphy, MJ Potter, MR Stanford, MS Savchenko, R Peek, R Peek, Richard G Weleber, SM Whitcup, YH Yoon   +31 more
core   +3 more sources

TRIM21: a cytosolic Fc receptor with broad antibody isotype specificity

Immunological Reviews, 2015
Antibodies are key molecules in the fight against infections. Although previously thought to mediate protection solely in the extracellular environment, recent research has revealed that antibody‐mediated protection extends to the cytosolic compartment ...
Stian Foss, R. Watkinson, I. Sandlie, L. James, J. Andersen   +4 more
semanticscholar   +1 more source

Ablation of LRP6 in alpha‐smooth muscle actin‐expressing cells abrogates lung inflammation and fibrosis upon bleomycin‐induced lung injury

FEBS Letters, EarlyView.
Low‐density lipoprotein receptor‐related protein 6 (LRP6) is a key receptor for the Wnt antagonist Dickkopf1 (DKK1). DKK1 protein expression is induced in a bleomycin (BLM)‐induced lung injury model. We show that DKK1 induces proinflammatory and profibrotic genes in lung fibroblasts.
Eun‐Ah Sung, Mikhail G. Dozmorov, SuJeong Song, Theingi Aung, Min Hee Park, Patricia J. Sime, Wook‐Jin Chae   +6 more
wiley   +1 more source

Specificity and overlap in gene segment-defined antibody repertoires

BMC Genomics, 2005
Background To date several studies have sought to catalog the full suite of antibodies that humans naturally produce against single antigens or other specificities (repertoire).
Arnaout Ramy A
doaj   +1 more source

A33 shows similar sensitivity to but is more specific than CDX2 as an immunomarker of colorectal carcinoma [PDF]

, 2017
Aims: CDX2 is widely used as a sensitive and specific immunomarker for colorectal carcinoma (CRC) but neither this sensitivity nor specificity is absolute. This study is the first known comparison of CDX1 and A33 against CDX2 as immunomarkers for CRC.
Adamczyk, Lukasz A., Cullen, Jayne, Evans, Shanna, Oien, Karin A., Oniscu, Anca, Wong, Newton A.C.S.   +5 more
core   +1 more source

Making tau amyloid models in vitro: a crucial and underestimated challenge

FEBS Letters, EarlyView.
This review highlights the challenges of producing in vitro amyloid assemblies of the tau protein. We review how accurately the existing protocols mimic tau deposits found in the brain of patients affected with tauopathies. We discuss the important properties that should be considered when forming amyloids and the benchmarks that should be used to ...
Julien Broc, Clara Piersson, Yann Fichou
wiley   +1 more source