Pyrimidine: a review on anticancer activity with key emphasis on SAR
Future Journal of Pharmaceutical Sciences, 2021 Cancer is a global health challenge, it impacts the quality of life and its treatment is associated with several side effects. Resistance of the cancer cells to the existing drugs has led to search for novel anticancer agents.
Aastha Mahapatra +2 more
semanticscholar +1 more source
Unleashing the full potential of Hsp90 inhibitors as cancer therapeutics through simultaneous inactivation of Hsp90, Grp94, and TRAP1 [PDF]
, 2020 Cancer therapeutics: Extending a drug's reach A new drug that blocks heat shock proteins (HSPs), helper proteins that are co-opted by cancer cells to promote tumor growth, shows promise for cancer treatment.
Chae, Young Chan +10 more
core +1 more source
Jurnal Farmasi Sains dan Komunitas, 2020 Brotowali (Tinosporacrispa L) is a plant which has potential to be a chemopreventive agent. This study aims to determine the profile of anticancer activity of brotowali stem extracts (Tinosporacrispa L.), from several regions in East Java. The extraction
Roihatul Mutiah +3 more
doaj +1 more source
Synthesis of novel fluorinated 1,5-benzothiazepine derivatives and their biological evaluation as anticancer and antibacterial agent [PDF]
Journal of the Serbian Chemical Society, 2022 A series of novel fluorinated 1,5-benzothiazepine derivatives were synthesized, characterized and evaluated for in vitro anticancer and antibacterial activity.
Bhabal Sonal R. +4 more
doaj +1 more source
TRIMming p53’s anticancer activity [PDF]
Oncogene, 2016 Several TRIM proteins control abundance and activity of p53. Along this route, TRIM proteins have a serious impact on carcinogenesis and prognosis for cancer patients. In the past years, a significant increase has been made in our understanding of how the TRIM protein family controls p53 activity.
Elabd, S, MERONI, GERMANA, Blattner, C.
openaire +4 more sources
Phenylselanyl Group Incorporation for “Glutathione Peroxidase-Like” Activity Modulation
Molecules, 2020 The ability of organoselenium molecules to mimic the activity of the antioxidant selenoenzyme glutathione peroxidase (GPx) allows for their use as antioxidant or prooxidant modulators in several diseases associated with the disruption of the cell redox ...
Magdalena Obieziurska-Fabisiak +6 more
doaj +1 more source
The Major Heat Shock Proteins, Hsp70 and Hsp90, in 2-Methoxyestradiol-Mediated Osteosarcoma Cell Death Model [PDF]
, 2020 2-Methoxyestradiol is one of the natural 17β-estradiol derivatives and a potential novel anticancer agent currently being under evaluation in advanced phases of clinical trials.
Cappello F. +8 more
core +1 more source
Structure–Activity Relationship of Benzofuran Derivatives with Potential Anticancer Activity
Cancers, 2022 Simple Summary Cancer is the leading cause of death worldwide and responsible for killing approximately 10 million people per year. Fused heterocyclic ring systems such as benzofuran have emerged as important scaffolds with many biological properties ...
Joviana Farhat +3 more
semanticscholar +1 more source
Menthol: An underestimated anticancer agent
Frontiers in Pharmacology, 2023 Menthol, a widely used natural, active compound, has recently been shown to have anticancer activity. Moreover, it has been found to have a promising future in the treatment of various solid tumors. Therefore, using literature from PubMed, EMBASE, Web of
Yijia Zhao +11 more
doaj +1 more source
In Vivo Anticancer Activity of AZD3965: A Systematic Review
Molecules, 2021 Proliferating cancer cells have high energy demands, which is mainly obtained through glycolysis. The transmembrane trafficking of lactate, a major metabolite produced by glycolytic cancer cells, relies on monocarboxylate transporters (MCTs).
Ana Silva +5 more
semanticscholar +1 more source