Results 81 to 90 of about 10,530,811 (405)

Synthesis of Curcumin Derivatives and Analysis of Their Antitumor Effects in Triple Negative Breast Cancer (TNBC) Cell Lines [PDF]

, 2019
We analyzed antitumor effects of a series of curcumin analogues. Some of them were obtained by reaction of substitution involving the two phenolic OH groups of curcumin while the analogues with a substituent at C-4 was prepared following an original ...
Barattucci A, Bonaccorsi PM, Labbozzetta M, Notarbartolo M, Poma P, Salerno TMG   +5 more
core   +1 more source

Anticancer Activity of Stilbene‐Based Derivatives

ChemMedChem, 2017
AbstractStilbene is an abundant structural scaffold in nature, and stilbene‐based compounds have been widely reported for their biological activity. Notably, (E)‐resveratrol and its natural stilbene‐containing derivatives have been extensively investigated as cardioprotective, potent antioxidant, anti‐inflammatory, and anticancer agents.
DE FILIPPIS, Barbara, AMMAZZALORSO, Alessandra, FANTACUZZI, MARIALUIGIA, GIAMPIETRO, Letizia, MACCALLINI, Cristina, AMOROSO, Rosa   +5 more
openaire   +3 more sources

Reciprocal control of viral infection and phosphoinositide dynamics

FEBS Letters, EarlyView.
Phosphoinositides, although scarce, regulate key cellular processes, including membrane dynamics and signaling. Viruses exploit these lipids to support their entry, replication, assembly, and egress. The central role of phosphoinositides in infection highlights phosphoinositide metabolism as a promising antiviral target.
Marie Déborah Bancilhon, Bruno Mesmin
wiley   +1 more source

Anticancer Activities of Brassinosteroids [PDF]

, 2012
Molecular and cellular effects of two groups of antiproliferative agents, natural brassinosteroids (BRs) and their synthetic derivatives, were examined in different human cancer cell lines and in primary endothelial cells in vitro. Natural and synthetic BRs caused growth inhibition, cell cycle arrest and initiation of apoptosis in many different cancer
Hoffmannová, L. (Lucie), Oklešťková, J. (Jana), Steigerová, J., Kohout, L. (Ladislav), Kolář, Z., Strnad, M. (Miroslav)   +5 more
openaire   +3 more sources

Groundbreaking Anticancer Activity of Highly Diversified Oxadiazole Scaffolds

International Journal of Molecular Sciences, 2020
Nowadays, an increasing number of heterocyclic-based drugs found application in medicinal chemistry and, in particular, as anticancer agents. In this context, oxadiazoles—five-membered aromatic rings—emerged for their interesting biological properties ...
A. Benassi, F. Doria, Valentina Pirota
semanticscholar   +1 more source

Anticancer activity of Hemsleya amabilis extract

Life Sciences, 2002
Hemsleya amabilis extract is derived from the medicinal herb Hemsleya amabilis, which has long been used to treat cancer and many other conditions. The underlying mechanism is not clear. To investigate Hemsleya amabili's anticancer activity, we have treated different types of cancer cells including human astrocytoma U87 cells, breast cancer cells MDA ...
Yang, BB, Wu, Y, Wu, J
openaire   +4 more sources

Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?

FEBS Letters, EarlyView.
This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes, Guilherme M. Azevedo, Amanda P. Barcellos, Diana Bahia   +3 more
wiley   +1 more source

Berberine hydrochloride: anticancer activity and nanoparticulate delivery system

International Journal of Nanomedicine, 2011
Wen Tan, Yingbo Li, Meiwan Chen, Yitao WangState Key Laboratory of Quality Research in Chinese Medicine, Institute of Chinese Medical Sciences, University of Macau, Macao Special Administrative Region, ChinaBackground: Berberine hydrochloride is a ...
Tan W, Li YB, Chen MW, Wang YT
doaj  

Synthesis and In Vitro Anticancer Activity of Pyrrolidone Derivatives Bearing 3,4,5-Trimethoxyphenyl Moiety as a Promising Anticancer Scaffold

Applied Sciences
A series of 5-oxo-1-(3,4,5-trimethoxyphenyl)pyrrolidine-3-carboxylic acid derivatives–hydrazones, N-ethylhydrazones, pyrrole, pyrazole, oxadiazole, and triazole were synthesized and evaluated for their anticancer activity using human A549 pulmonary ...
Povilas Kavaliauskas, Birutė Sapijanskaitė-Banevič, Birutė Grybaitė, Eglė Mickevičiūtė, Kazimieras Anusevičius, Andrew Garcia, Ethan Naing, Rūta Petraitienė, Vidmantas Petraitis, Ramunė Grigalevičiūtė, Vytautas Mickevičius   +10 more
doaj   +1 more source

Cn-AMP2 from green coconut water is an anionic anticancer peptide [PDF]

, 2014
Globally, death due to cancers is likely to rise to over 20 million by 2030,which has created an urgent need for novel approaches to anticancer therapies such as the development of host defence peptides.
Al-Benna, Avner, Balderas-Renteria, Bray, Chan, Cho, Cho, Cragg, Cragg, Dawson, Dennison, Dennison, Dennison, Dennison, Gaspar, Gotay, Harris, Harris, Harris, Harris, Harris, Hess, Hogberg, Khazir, Li, Lumb, Malde, Mandal, Mandal, Martin Sabroso, Newman, Nicolas, Oh, Pasupuleti, Phoenix, Phoenix, Phoenix, Phoenix, Prabhu, Prabhu, Rajanbabu, Riedl, Saraswathy, Shekhar, Song, Tsuda, Unnati, Urruticoechea, Van der Spoel, Varadhachary, Wall, Wang, Wang, Whitmore, Whitmore, Whitmore, Yeung   +56 more
core   +1 more source