Results 1 to 10 of about 170,034 (262)

Menthol: An underestimated anticancer agent [PDF]

Frontiers in Pharmacology, 2023
Menthol, a widely used natural, active compound, has recently been shown to have anticancer activity. Moreover, it has been found to have a promising future in the treatment of various solid tumors. Therefore, using literature from PubMed, EMBASE, Web of
Yijia Zhao, Huafeng Pan, Wei Liu, E. Liu, Yaobin Pang, Hongjin Gao, Qingying He, Wenhao Liao, Yejing Yao, Jinhao Zeng, Jinhao Zeng, Jing Guo   +11 more
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Design, synthesis, and biological evaluation of 5-((4-(pyridin-3-yl)pyrimidin-2-yl)amino)-1H-Indole-2-Carbohydrazide derivatives: the methuosis inducer 12A as a Novel and selective anticancer agent

Journal of Enzyme Inhibition and Medicinal Chemistry, 2021
This study describes the synthesis and vacuole-inducing activity of 5-((4-(pyridin-3-yl)pyrimidin-2-yl)amino)-1H-indole-2-carbohydrazide derivatives, including five potent derivatives 12c, 12 g, 12i, 12n, and 12A that exhibit excellent vacuole-inducing ...
Jun Wu, Hongyu Hu, Mingtao Ao, Zhenzhen Cui, Xiaoping Zhou, Jingbo Qin, Yafei Guo, Jingwei Chen, Yuhua Xue, Meijuan Fang   +9 more
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Construction of an Artificial Biosynthetic Pathway for the Styrylpyrone Compound 11-Methoxy-Bisnoryangonin Produced in Engineered Escherichia coli

Frontiers in Microbiology, 2021
A cDNA clone (named pnpks), which shows high homology to the known chalcone synthase (CHS)-like type III PKS, was obtained from the leaves of Piper nigrum.
Kyung Taek Heo, Kyung Taek Heo, Byeongsan Lee, Jae-Hyuk Jang, Jae-Hyuk Jang, Jung-Oh Ahn, Jung-Oh Ahn, Young-Soo Hong, Young-Soo Hong   +8 more
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RETRACTED: LacI-Family Transcriptional Regulator DagR Acts as a Repressor of the Agarolytic Pathway Genes in Streptomyces coelicolor A3(2)

Frontiers in Microbiology, 2021
Actinobacteria utilize various polysaccharides in the soil as carbon source by degrading them via extracellular hydrolytic enzymes. Agarose, a marine algal polysaccharide composed of D-galactose and 3,6-anhydro-L-galactose (AHG), is one of the carbon ...
Maral Tsevelkhoroloo, So Heon Shim, Chang-Ro Lee, Soon-Kwang Hong, Young-Soo Hong   +4 more
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Ent-Peniciherqueinone Suppresses Acetaldehyde-Induced Cytotoxicity and Oxidative Stress by Inducing ALDH and Suppressing MAPK Signaling

Pharmaceutics, 2020
Studies on ethanol-induced stress and acetaldehyde toxicity are actively being conducted, owing to an increase in alcohol consumption in modern society.
Taehoon Oh, Mincheol Kwon, Jae Sik Yu, Mina Jang, Gun-Hee Kim, Ki Hyun Kim, Sung-Kyun Ko, Jong Seog Ahn   +7 more
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Wnt3a Stimulation Promotes Primary Ciliogenesis through β-Catenin Phosphorylation-Induced Reorganization of Centriolar Satellites

Cell Reports, 2020
Summary: Primary cilium is an antenna-like microtubule-based cellular sensing structure. Abnormal regulation of the dynamic assembly and disassembly cycle of primary cilia is closely related to ciliopathy and cancer.
Mi-Lang Kyun, Sun-Ok Kim, Hee Gu Lee, Jeong-Ah Hwang, Joonsung Hwang, Nak-Kyun Soung, Hyunjoo Cha-Molstad, Sangku Lee, Yong Tae Kwon, Bo Yeon Kim, Kyung Ho Lee   +10 more
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Anti-Cancer Agent: The Labdane Diterpenoid-Andrographolide

Plants, 2023
In spite of the progress in treatment strategies, cancer remains a major cause of death worldwide. Therefore, the main challenge should be the early diagnosis of cancer and the design of an optimal therapeutic strategy to increase the patient’s life ...
Rosa Tundis, Jayanta Kumar Patra, Marco Bonesi, Subrata Das, Rajat Nath, Anupam Das Talukdar, Gitishree Das, Monica Rosa Loizzo   +7 more
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Cytotoxic Activities and Molecular Mechanisms of the Beauvericin and Beauvericin G₁ Microbial Products against Melanoma Cells

Molecules, 2020
Melanoma is the most serious type of skin cancer and remains highly drug-resistant. Therefore, the discovery of novel effective agents against melanoma is in high demand.
Haet Nim Lim, Jun-Pil Jang, Hee Jeong Shin, Jae-Hyuk Jang, Jong Seog Ahn, Hye Jin Jung   +5 more
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Lithium: A Promising Anticancer Agent

Life, 2023
Lithium is a therapeutic cation used to treat bipolar disorders but also has some important features as an anti-cancer agent. In this review, we provide a general overview of lithium, from its transport into cells, to its innovative administration forms,
Edgar Yebrán Villegas-Vázquez, Laura Itzel Quintas-Granados, Hernán Cortés, Manuel González-Del Carmen, Gerardo Leyva-Gómez, Miguel Rodríguez-Morales, Lilia Patricia Bustamante-Montes, Daniela Silva-Adaya, Carlos Pérez-Plasencia, Nadia Jacobo-Herrera, Octavio Daniel Reyes-Hernández, Gabriela Figueroa-González   +11 more
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Green Synthesized Silver Nanoparticles: Antibacterial and Anticancer Activities, Biocompatibility, and Analyses of Surface-Attached Proteins

Frontiers in Microbiology, 2021
The increasing number of multi-drug-resistant bacteria and cancer cases, that are a real threat to humankind, forces research world to develop new weapons to deal with it. Biogenic silver nanoparticles (AgNPs) are considered as a solution to this problem.
Magdalena Wypij, Tomasz Jędrzejewski, Joanna Trzcińska-Wencel, Maciej Ostrowski, Mahendra Rai, Mahendra Rai, Patrycja Golińska   +6 more
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