Results 21 to 30 of about 170,034 (262)

Herbal Melanin Inhibits Real-Time Cell Proliferation, Downregulates Anti-Apoptotic Proteins and Upregulates Pro-Apoptotic p53 Expression in MDA-MB-231 and HCT-116 Cancer Cell Lines

Medicina, 2023
Background and Objectives: Cancer is the second-most-important deadly disease in the world, leading to severe socioeconomic consequences and posing a public threat.
Jothi Ramalingam Rajabathar, Hamad Al-Lohedan, Selvaraj Arokiyaraj, Fathima Mohammed, Dhaifallah M. Al-Dhayan, Norah A. Faqihi, Hassan Al-Saigh   +6 more
doaj   +1 more source

Rhodium complex [RhLI₂]I: a novel anticancer agent inducing tumor inhibition and apoptosis. [PDF]

Discov Oncol
Numerous chemotherapeutic agents are currently employed in cancer treatment, but many are associated with significant side effects. This study aims to identify a novel anticancer drug that minimizes or eliminates these adverse effects.
Hossain MM, Soha K, Rahman A, Auwal A, Pronoy TUH, Rashel KM, Nurujjaman M, Rahman H, Roy TG, Khanam JA, Islam F.   +10 more
europepmc   +2 more sources

Metal complexes as DNA intercalators [PDF]

, 2011
DNA has a strong affinity for many heterocyclic aromatic dyes, such as acridine and its derivatives. Lerman in 1961 first proposed intercalation as the source of this affinity, and this mode of DNA binding has since attracted considerable research ...
Peter J. Sadler, Hong-Ke Liu, Sadler, P. J., Liu, Hong-Ke   +3 more
core   +1 more source

Glycyrrhizinic Acid as an Antiviral and Anticancer Agent in the Treatment of Human Papillomavirus [PDF]

, 2023
Human papillomavirus (HPV), like any other virus, needs to penetrate the host cell and make use of its machinery to replicate. From there, HPV infection can be asymptomatic or lead to benign and premalignant lesions or even different types of cancer. HPV
Serrano Velasco, María, Juan Ferragud, Victoria Bravo, Alfonso Duque, Pluvio J. Coronado, Serrano, María, Coronado Martín, Pluvio Jesús, Bravo, Victoria, Coronado, Pluvio J., Coronado, Pluvio J, Ferragud, Juan, Duque, Alfonso, María Serrano   +12 more
core   +1 more source

A chemical with proven clinical safety rescues Down-syndrome-related phenotypes in through DYRK1A inhibition

Disease Models & Mechanisms, 2016
DYRK1A is important in neuronal development and function, and its excessive activity is considered a significant pathogenic factor in Down syndrome and Alzheimer's disease.
Hyeongki Kim, Kyu-Sun Lee, Ae-Kyeong Kim, Miri Choi, Kwangman Choi, Mingu Kang, Seung-Wook Chi, Min-Sung Lee, Jeong-Soo Lee, So-Young Lee, Woo-Joo Song, Kweon Yu, Sungchan Cho   +12 more
doaj   +1 more source

Design and encapsulation of anticancer dual HSP27 and HER2 inhibitor into low density lipoprotein to target ovarian cancer cells

Saudi Pharmaceutical Journal, 2020
Tumor cells overexpress low-density lipoprotein (LDL) receptors (LDL-r). Hence, LDL is proposed as a targeting shuttle of anticancer drugs. Therefore, the objective of this study was to synthesize a dual inhibitor of heat shock protein 27 (HSP27) and ...
Laila J. Alhadad, Gamaleldin I. Harisa, Fars K. Alanazi   +2 more
doaj   +1 more source

Organometallic half-sandwich iridium anticancer complexes [PDF]

, 2011
The low-spin 5d6 IrIII organometallic half-sandwich complexes [(η5-Cpx)Ir(XY)Cl]0/+, Cpx = Cp*, tetramethyl(phenyl)cyclopentadienyl (Cpxph), or tetramethyl(biphenyl)cyclopentadienyl (Cpxbiph), XY = 1,10-phenanthroline (4−6), 2,2′-bipyridine (7−9 ...
Liu, Zhe, Bruijnincx, P.C.A., Brabec, V., Clarkson, Guy J., Sally A. Fletcher, Liu, Z., Vrana, O., Guy J. Clarkson, Fletcher, Sally A., Vrana, Oldrich, Salassa, Luca, Brabec, V. (Viktor), Fletcher, S.A., Kisova, A., Peter J. Sadler, Clarkson, G.J., Pizarro, A.M., Viktor Brabec, Bruijnincx, Pieter C. A., Oldrich Vrana, Sadler, P. J., Pieter C. A. Bruijnincx, Zhe Liu, Salassa, L., Luca Salassa, Habtemariam, A., Inorganic Chemistry and Catalysis, Sub Inorganic Chemistry and Catalysis, Pizarro, Ana M., Sadler, Peter J., Ana M. Pizarro, Kisova, Anna, Habtemariam, Abraha, Abraha Habtemariam, Anna Kisova   +34 more
core   +1 more source

The Novel Small Molecule STK899704 Promotes Senescence of the Human A549 NSCLC Cells by Inducing DNA Damage Responses and Cell Cycle Arrest

Frontiers in Pharmacology, 2018
The novel synthetic compound designated STK899704 (PubChem CID: 5455708) suppresses the proliferation of a broad range of cancer cell types. However, the details of its effect on lung cancer cells are unclear.
Chan-Woo Park, Yesol Bak, Min-Je Kim, Ganipisetti Srinivasrao, Joonsung Hwang, Nak K. Sung, Bo Yeon Kim, Jae-Hyuk Yu, Jin Tae Hong, Do-Young Yoon   +9 more
doaj   +1 more source

Computational Fluid Dynamics Study of Superselective Intra-arterial Chemotherapy for Oral Cancer: Flow Simulation of Anticancer Agent in the Linguofacial Trunk

Applied Sciences, 2020
Superselective intra-arterial chemotherapy (SSIAC) for oral cancer can deliver a higher concentration of anticancer agent into a tumor-feeding artery than intravenous systemic chemotherapy.
Hiroaki Kitajima, Toshinori Iwai, Yasuharu Yajima, Kenji Mitsudo   +3 more
doaj   +1 more source

The contrasting activity of iodido versus chlorido ruthenium and osmium arene azo- and imino-pyridine anticancer complexes : control of cell selectivity, cross-resistance, p53 dependence, and apoptosis pathway [PDF]

, 2013
Organometallic half-sandwich complexes [M(p-cymene)(azo/imino-pyridine)X]+ where M = RuII or OsII and X ═ Cl or I, exhibit potent antiproliferative activity toward a range of cancer cells.
Sadler, P. J., Romero-Canelón, Isolda, Salassa, Luca   +2 more
core   +1 more source