Somatostatin subtype-2 receptor-targeted metal-based anticancer complexes [PDF]
, 2012 Conjugates of a dicarba analogue of octreotide, a potent somatostatin agonist whose receptors are overexpressed on tumor cells, with [PtCl 2(dap)] (dap = 1-(carboxylic acid)-1,2-diaminoethane) (3), [(η 6-bip)Os(4-CO 2-pico)Cl] (bip = biphenyl, pico ...
González, Carlos A. +24 more
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Towards safety of oral anti-cancer agents, the need to educate our pharmacists
Saudi Pharmaceutical Journal, 2017 Introduction: The global prevalence of cancer is rising. Use of oral anticancer medications has expanded exponentially. Knowledge about these medications as well as safe handling guidelines has not kept abreast with the rapidity these medications are ...
Sanaa Saeed Mekdad, Adher Dhaya AlSayed
doaj +1 more source
A radiologist’s guide to novel anticancer therapies in the era of precision medicine
European Journal of Radiology Open, 2022 Novel anticancer agents have replaced conventional chemotherapy as first line agents for many cancers, with continued new and expanding indications.
Ali Khader +6 more
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VEGFER-2 INHIBITORS AND QUINAZOLINE-BASED ANTICANCER AGENTS [PDF]
Al-Azhar Journal of Pharmaceutical Sciences, 2023 Inhibitors of vascular endothelial growth factor receptor -2 (VEGFR-2) are crucial biological targets for the development of novel anticancer medications.
Helmy Sakr +3 more
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A Multitargeted Approach in the Discovery of an Organorhodium Anticancer Agent Based On Vorinostat as a Potent Histone Deacetylase Inhibitor. [PDF]
, 2020 The combination of more than one bioactive moiety in a mulitargeted anticancer agent may result in synergistic activity of its components. Using this concept, bioorganometallic compounds were designed to feature a metal center, a 2-pyridinecarbothioamide
Reynisson
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Acetylenic Terrestrial Anticancer Agents
Natural Product Communications, 2006 Acetylenic metabolites belong to a class of molecules containing triple bond(s). They are found in plants, fungi, microorganisms, and marine invertebrates.
Valery M Dembitsky, Dmitri O Levitsky
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Organometallic iridium(III) anticancer complexes with new mechanisms of action: NCI-60 screening, mitochondrial targeting, and apoptosis [PDF]
, 2013 Platinum complexes related to cisplatin, cis-[PtCl2(NH3)2], are successful anticancer drugs; however, other transition metal complexes offer potential for combating cisplatin resistance, decreasing side effects, and widening the spectrum of activity ...
Hands-Portman, Ian +5 more
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Metal complexes as DNA intercalators [PDF]
, 2011 DNA has a strong affinity for many heterocyclic aromatic dyes, such as acridine and its derivatives. Lerman in 1961 first proposed intercalation as the source of this affinity, and this mode of DNA binding has since attracted considerable research ...
Peter J. Sadler +3 more
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Bacteriocins as potential anticancer agents
Frontiers in Pharmacology, 2015 Cancer remains one of the leading causes of deaths worldwide, despite advances in its treatment and detection. The conventional chemotherapeutic agents used for the treatment of cancer have nonspecific toxicity towards normal body cells that cause ...
Sukhraj eKaur, Sumanpreet eKaur
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Complexes of Ruthenium(II) as Promising Dual-Active Agents against Cancer and Viral Infections
Pharmaceuticals, 2023 Poor responses to medical care and the failure of pharmacological treatment for many high-frequency diseases, such as cancer and viral infections, have been widely documented.
Assunta D’Amato +6 more
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