Results 31 to 40 of about 241,274 (262)
HDAC inhibitors increase NRF2-signaling in tumour cells and blunt the efficacy of co-adminstered cytotoxic agents [PDF]
, 2014 The NRF2 signalling cascade provides a primary response against electrophilic chemicals and oxidative stress. The activation of NRF2-signaling is anticipated to have adverse clinical consequences; NRF2 is activated in a number of cancers, additionally ...
A Kenneth MacLeod +17 more
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Combination chemotherapy with anticancer agents and OK-432
, 1974 Antitumor effects of the combination chemotherapy with hemolytic streptococcus preparation, OK-432, and various anticancer agents were observed on experimental tumors and human cancers.
Sugiyama, Motoharu +6 more
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CHAPTER 5. Anticancer Gold Compounds
, 2019 The use of gold in medicine has a long history that dates back to ancient times. In modern medicine, gold compounds have been applied as anti-inflammatory agents for the treatment of rheumatoid arthritis.
Chun-Nam Lok +5 more
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Copper complexes as anticancer agents
, 2009 Metal-based antitumor drugs play a relevant role in antiblastic chemotherapy. Cisplatin is regarded as one of the most effective drugs, even if severe toxicities and drug resistance phenomena limit its clinical use.
F. TISATO +3 more
core +2 more sources
Anticancer Agents Targeted to Sirtuins
Molecules, 2014 Sirtuins are nicotinamide adenine dinucleotide+-dependent deacetylases of which there are seven isoforms (SIRT1–7). Sirtuin activity is linked to gene expression, lifespan extension, neurodegeneration, and age-related disorders.
Tomohiro Kozako +5 more
doaj +1 more source
A comprehensive review on pyrazoline based heterocyclic hybrids as potent anticancer agents
European Journal of Medicinal Chemistry Reports, 2022 Cancer is one of the leading causes of death globally, around 10 million deaths are reported every year due to cancer. Some clinically approved anticancer drugs play a riveting role in its treatment. Still, due to the severe emergence of drug resistance,
Kashif Haider +3 more
doaj +1 more source
, 2011 According to the Surveillance Epidemiology and End Results report, 1,479,350 men and women will be diagnosed with and 562,340 will die of cancer of all sites in 2009, indicating that about 40% of the cancer patients do not respond well to current ...
Alexei Vazquez
core +1 more source
The contrasting activity of iodido versus chlorido ruthenium and osmium arene azo- and imino-pyridine anticancer complexes : control of cell selectivity, cross-resistance, p53 dependence, and apoptosis pathway [PDF]
, 2013 Organometallic half-sandwich complexes [M(p-cymene)(azo/imino-pyridine)X]+ where M = RuII or OsII and X ═ Cl or I, exhibit potent antiproliferative activity toward a range of cancer cells.
Sadler, P. J. +2 more
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Biochemistry and Biophysics Reports, 2022 Anticancer agents can effectively treat several types of cancers but are often limited in clinical settings due to various adverse effects. In particular, nausea and vomiting are serious side effects that markedly reduce the patients' quality of life ...
Hiroto Yanagawa +4 more
doaj +1 more source
PharmaceuticsBackground: Despite improved knowledge on cancer prevention, progression, and treatment, the incidence of cancer is still increasing. Patients with highly aggressive triple-negative breast cancer benefit from chemotherapy as the only systemic therapeutic
Crina Elena Tiron +10 more
doaj +1 more source