Results 1 to 10 of about 88,387 (345)

Embryonic Hypotaurine Levels Contribute to Strain-Dependent Susceptibility in Mouse Models of Valproate-Induced Neural Tube Defects

Frontiers in Cell and Developmental Biology, 2022
Valproic acid (VPA, valproate, Depakote) is a commonly used anti-seizure medication (ASM) in the treatment of epilepsy and a variety of other neurological disorders.
John W. Steele, Ying Linda Lin, Nellie Chen, Nellie Chen, Bogdan J. Wlodarczyk, Qiuying Chen, Nabeel Attarwala, Madhu Venkatesalu, Madhu Venkatesalu, Robert M. Cabrera, Steven S. Gross, Richard H. Finnell, Richard H. Finnell, Richard H. Finnell   +13 more
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Extract of Euterpe oleracea Martius Stone Presents Anticonvulsive Activity via the GABAA Receptor

Frontiers in Cellular Neuroscience, 2022
Epilepsy is one of the most common neurological diseases globally, resulting from a disorder in brain activity. This condition can be triggered by birth trauma, traumatic brain injury (TBI), infections of the brain and stroke. More than 70 million people
Nilton Akio Muto, Moisés Hamoy, Chryslen Brenda da Silva Ferreira, Akira Otake Hamoy, David Cristian Rodrigues Lucas, Vanessa Jóia de Mello, Hervé Rogez   +6 more
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Natural Coumarin-Lead Compounds: A Review of Their Medicinal Potentials [PDF]

المجلة العراقية للصيدلة, 2022
Background: Natural coumarins group, a principal member of the benzopyrone family, is one of the naturally occurring substances obtained ordinarily from plant origins, with antibacterial, anticoagulant, antihypertensive, anticancer, antioxidant, anti ...
Rahma Jebir, Yasser Mustafa
doaj   +1 more source

Continuous rate infusion of midazolam as emergent treatment for seizures in dogs

Journal of Veterinary Internal Medicine, 2021
Background Midazolam delivered by continuous rate infusion (CRI) might be effective in dogs with cluster seizures (CS) or status epilepticus (SE). Objective To describe the use and safety of midazolam CRI in dogs with CS or SE.
Kathryn Y. Bray, Christopher L. Mariani, Peter J. Early, Karen R. Muñana, Natasha J. Olby   +4 more
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Preparation of Nanocrystals for Insoluble Drugs by Top-Down Nanotechnology with Improved Solubility and Bioavailability

Molecules, 2020
Midazolam is a rapidly effective benzodiazepine drug that is widely used as a sedative worldwide. Due to its poor solubility in a neutral aqueous solution, the clinical use of midazolam is significantly limited.
Xun Zhang, Zhiguo Li, Jing Gao, Zengming Wang, Xiang Gao, Nan Liu, Meng Li, Hui Zhang, Aiping Zheng   +8 more
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Sodium Valproate Induced Alopecia: A Case Series [PDF]

Journal of Clinical and Diagnostic Research, 2017
Drug induced alopecia may range from a barely detectable shedding to an irreversible baldness. Alopecia associated with valproate is a dose-dependent and reversible side effect.
Sereen Rose Thomson, Vinay Mamulpet, Shalini Adiga   +2 more
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Novel 2-substituted-5-(4-chloro-2-phenoxy)phenyl-1,3,4-oxadiazole derivatives, ligands of GABAA/benzodiazepine receptor complex

EXCLI Journal : Experimental and Clinical Sciences, 2023
Agonists of Benzodiazepine (BZD) receptor are exhaustively used in the control of muscle spasms, seizure, anxiety, and insomnia. BZDs have some unwanted effects; therefore, the development of new BZD receptor agonists with better efficacy and fewer ...
Elham Rezaee, Fatemeh Ahmadi, Mahsa Shabaninia, Mona Khoramjouy, Zahra Azizi Farsani, Soraya Shahhosseini, Sayyed Abbas Tabatabai, Mehrdad Faizi   +7 more
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Patient Harm Resulting From Medication Reconciliation Process Failures: A Study of Serious Events Reported by Pennsylvania Hospitals

Patient Safety, 2021
Medication reconciliation broadly defined includes both formal and informal processes that involve the comprehensive evaluation of a patient’s medications during each transition of care and change in therapy.
Amy Harper, Elizabeth Kukielka, Rebecca Jones   +2 more
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Synthesis and Pharmacological Evaluation of Novel Benzenesulfonamide Derivatives as Potential Anticonvulsant Agents

Molecules, 2015
A novel series of benzenesulfonamide derivatives containing 4-aminobenzenesul-fonamide and α-amides branched valproic acid or 2,2-dimethylcyclopropanecarboxylic acid moieties were synthesized and screened for their anticonvulsant activities in mice ...
Zhiming Wang, Jinping Li, Xiao-Dong Zeng, Xian-Ming Hu, Xiaoju Zhou, Xuechuan Hong   +5 more
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Neuropharmacological Activity of the Acetonic Extract of Malpighia mexicana A. Juss. and Its Phytochemical Profile

Scientia Pharmaceutica, 2023
Mental and neurological disorders are conditions that affect thoughts, emotions, behavior, and relationships. Malpighia mexicana A. Juss. is a plant used in Mexican traditional medicine for the treatment of such disorders.
Dante Avilés-Montes, David Osvaldo Salinas-Sánchez, César Sotelo-Leyva, Alejandro Zamilpa, Franceli Itzel Batalla-Martinez, Rodolfo Abarca-Vargas, Juan Manuel Rivas-González, Óscar Dorado, Rodolfo Figueroa-Brito, Vera L. Petricevich, Dulce Lourdes Morales-Ferra, Manasés González-Cortazar   +11 more
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