Results 101 to 110 of about 131,323 (382)

Synthesis, molecular docking, electrochemical and fluorimetric analysis of new caffeic and cinnamic acid-conjugated hemorphin derivatives designed as potential anticonvulsant and antinociceptive agents

, 2023
Petаr Todorov, Stela Georgieva, Petia Peneva, Spas Nikolov, Miroslav Rangelov, Nadezhda Todorova, Daniela Pechlivanova, Jana Tchekalarova   +7 more
openalex   +1 more source

Seizure Disorders in Goats and Sheep. [PDF]

, 2016
BackgroundGoats and sheep are more likely to be presented for examination for seizures than are cattle, possibly as a consequence of their relatively smaller body size.
Aleman, M, Chigerwe, M
core   +1 more source

Targeting Hsp90 with cemdomespib reduces seizure burden and alters disease course in preclinical epilepsy models

Epilepsia, EarlyView.
Abstract Objective Epilepsy is a chronic neurological disorder characterized by recurrent seizures and frequent cognitive and psychiatric comorbidities. Although current antiseizure medications provide symptomatic relief, they fail to prevent or modify epileptogenesis.
Yara Sheeni, Prince Kumar Singh, Sereen Sandouka, Taige Zhang, Alina Nemirovski, Aseel Saadi, Rhoda Olowe Taiwo, Matthew C. Walker, Tawfeeq Shekh‐Ahmad   +8 more
wiley   +1 more source

Cyclooxygenase-1 as a potential therapeutic target for seizure suppression: evidences from zebrafish pentylenetetrazole-seizure model

Frontiers in Neurology, 2016
Cyclooxygenases (COX) -1 and -2 are isoenzymes that catalyze the conversion of arachidonic acid into prostaglandins (PGs). COX-2 and PGs are rapidly increased following seizures and are known to play important roles in the neuroinflammatory process.
Patricia Gonçalves Barbalho, Benilton de Sá Carvalho, Iscia Lopes-Cendes, Claudia Vianna Maurer-Morelli   +3 more
doaj   +1 more source

Video-EEG long term monitoring as a new service at Mater Dei Hospital [PDF]

, 2016
Introduction: Video-EEG long-term monitoring (LTM) was introduced into Mater Dei Hospital (MDH) in May 2012. The audit aims to evaluate LTM in terms of diagnostic outcomes and impact on patient management.
Aquilina, Josanne, Galea, Bernard, Gravino, Gilbert, Soler, Doriette, Vella, Norbert   +4 more
core  

L‐Relationship between uncertainty and average seizure frequency in clinical trials of antiseizure medications

Epilepsia, EarlyView.
Abstract Objective Antiseizure medications are approved based on clinical trials that demonstrate their efficacy as measured by reductions in seizure frequency (SF). When designing these trials, trialists must select inclusion criteria where SF can be reliably measured to maintain statistical power.
Wesley T. Kerr, Neo Kok, Katherine N. McFarlane, Advith S. Reddy, Lavanya Biju, Jacqueline A. French, Daniel M. Goldenholz   +6 more
wiley   +1 more source

Hematopoietic effects of spleen lymphocytes treated with an original anticonvulsant during long-term alcohol consumption

Медицинская иммунология
Excessive alcohol consumption has a negative effect on hematopoiesis, which manifests with significant suppression of both blood cell production, and structural changes in hematopoietic precursors, i.e., by suppression of their maturation, up to ...
I. A. Orlovskaya, E. V. Markova, I. V. Savkin, L. B. Toporkova, M. A. Knyazheva, E. V. Serenko, A. V. Smyk, E. V. Goiman   +7 more
doaj   +1 more source

Innovative Technology of the Self-Emulsifying Drug Delivery System of the Anticonvulsant Galodif [PDF]

, 2023
Vera Yu. Kuksenok, V. V. Shtrykova, В. Д. Филимонов, T. Shushpanova, Н. А. Бохан, L. Seilerová, B. Kratohvil, V. Sieberová   +7 more
openalex   +1 more source

An Exploratory Analysis of Pharmaceutical Price Disparities and Their Implications Among Six Developed Nations [PDF]

, 2006
In our study of 43 drugs, prescription drug prices in several wealthy nations (Australia, Canada, France, Germany, and the U.K.) were much lower than in the U.S. on average, well below relative per capita GDP. There was relatively little difference among
Elizabeth DuPre, John E. Calfee, Mario Villarreal   +2 more
core  

Involvement of PPAR\u3b3 in the anticonvulsant activity of EP-80317, a ghrelin receptor antagonist [PDF]

, 2017
Ghrelin, des-acyl ghrelin and other related peptides possess anticonvulsant activities. Although ghrelin and cognate peptides were shown to physiologically regulate only the ghrelin receptor, some of them were pharmacologically proved to activate the ...
Anna M. Costa, Antonio Torsello, Carmela Giordano, Chiara Lucchi, Giulia Curia, Giuseppe Biagini, Giuseppe Biagini, Giuseppina Leo, Jean Martinez, Jean-Alain Fehrentz, Jonathan Vinet, Luc Brunel, Marika Piat   +12 more
core   +3 more sources