Results 101 to 110 of about 128,593 (391)

A New Anticonvulsant Pregabalin: Preclinical Data

open access: yesTürk Nöroloji Dergisi, 2008
Pregabalin is a highly potent compound with a newly defined mechanism of action that is showing activity in a number of conditions, such as epilepsy, anxiety, neuropathic pain. Although it is a structural analog of δ-aminobutyric acid (GABA), it does not
Mert Ceyhan, Ersin Tan
doaj  

Synthesis, Modelling, and Anticonvulsant Studies of New Quinazolines Showing Three Highly Active Compounds with Low Toxicity and High Affinity to the GABA-A Receptor

open access: yesMolecules, 2017
Some novel fluorinated quinazolines (5a–j) were designed and synthesized to be evaluated for their anticonvulsant activity and their neurotoxicity. Structures of all newly synthesized compounds were confirmed by their infrared (IR), mass spectrometry (MS)
Mohamed F. Zayed   +5 more
doaj   +1 more source

New Aspects of Thromboangiitis obliterans (von Winiwarter-Buerger's Disease) [PDF]

open access: yes, 1984
The existence of thromboangiitis obliterans as a clinical entity has been a matter of debate for many years. In contrast to other immunovasculitides there is no organ involvement while peripheral vessels are affected.
Berlit, Peter   +3 more
core   +1 more source

Nonsteroidal Anti‐Inflammatory Drugs as Modulators of Cation Channels: Fenamates Repurposing in Channelopathies

open access: yesChemMedChem, EarlyView.
Beyond their established role as nonsteroidal anti‐inflammatory drugs (NSAIDs), fenamates (niflumic, flufenamic, mefenamic, meclofenamic, and tolfenamic acids) have recently been identified as modulators of cationic ion channels. This review highlights their differential effects on ion channel activity and explores their potential for repurposing in ...
Paola Laghetti   +4 more
wiley   +1 more source

Anticonvulsant activity of Nigella sativa, Aegle marmelos and Benincasa hispida in Pentylenetetrazole induced seizure in Swiss albino mice

open access: yesAsian Journal of Medical Sciences, 2016
Aims and Objectives: To test anticonvulsant properties of three medicinal plants with pentylenetetrazole induced seizure test in Swiss albino mice. Materials and Methods: Herbs selected for the work (leaves of Aegle marmelos, seed of Nigella sativa ...
Rejeesh Edavan Puthallath
doaj   +1 more source

Reactions of p-Nitrophenyloxirane with Amines Containing Fragments with Bicyclic Skeleton [PDF]

open access: yes, 2002
Reactions of p-nitrophenyloxirane with amines containing fragments with bicyclic skeleton of norbornene, norbornane, epoxynorbornane (stereoisomeric exo- and endo-5-aminomethylbicyclo[2.2.1]hept-2-enes, N-benzyl-endo-5-aminomethylbicyclo[2.2.1]hept-2-ene,
Golodaeva, E. A.   +3 more
core  

Phenobarbital Bioequivalence in Chinese Population: Considering the Role of Food on Pharmacokinetics

open access: yesClinical Pharmacology in Drug Development, EarlyView.
Abstract Epilepsy is one of the most severe neurological disorders in the world, which might seriously endanger the lives of patients. Phenobarbital is an important medicine clinically used for the treatment of epilepsy, and it is irreplaceable in the treatment of generalized tonic–clonic seizures, focal seizures, status epilepticus, and pediatric ...
Wang Xinman   +3 more
wiley   +1 more source

Anticonvulsant Activity of Aqueous Extract of Andrographis paniculata Leaves in Wistar Albino Rats

open access: yesNational Board of Examinations Journal of Medical Sciences
Background: The anticonvulsant effect of Aqueous Extract of Andrographis paniculata leaves (AEAP) and its synergistic action with Sodium valproate were evaluated in this research. Methods: Anticonvulsant activity of AEAP 500 mg/kg b.w.
M S Umamageswari   +6 more
doaj   +1 more source

Unusual Presentation of Seizure in a Child: A Case of Abdominal Epilepsy and Associated Diagnostic Dilemmas [PDF]

open access: yesJournal of Clinical and Diagnostic Research
Abdominal Epilepsy (AE) is a rare and often under-recognised form of epilepsy that typically presents in children with gastrointestinal symptoms, such as recurrent vomiting.
M Sherin Fathima, R Ramya, S Sundari
doaj   +1 more source

Video-EEG long term monitoring as a new service at Mater Dei Hospital [PDF]

open access: yes, 2016
Introduction: Video-EEG long-term monitoring (LTM) was introduced into Mater Dei Hospital (MDH) in May 2012. The audit aims to evaluate LTM in terms of diagnostic outcomes and impact on patient management.
Aquilina, Josanne   +4 more
core  

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