Results 11 to 20 of about 86,557 (245)
Recent developments on triazole nucleus in anticonvulsant compounds: a review
Journal of Enzyme Inhibition and Medicinal Chemistry, 2018 Epilepsy is one of the common diseases seriously threatening life and health of human. More than 50 million people are suffering from this condition and anticonvulsant agents are the main treatment.
Ming-Xia Song, Xian-Qing Deng
doaj +2 more sources
Thiazole-Bearing 4-Thiazolidinones as New Anticonvulsant Agents
Scientia Pharmaceutica, 2020 Here, we describe the synthesis and anticonvulsant activity of thiazole-bearing hybrids based on 2-imino-4-thiazolidinone and 2,4-dioxothiazolidine-5-carboxylic acid cores.
M. Mishchenko +3 more
semanticscholar +1 more source
Randomized Trial of Three Anticonvulsant Medications for Status Epilepticus.
New England Journal of Medicine, 2019 BACKGROUND The choice of drugs for patients with status epilepticus that is refractory to treatment with benzodiazepines has not been thoroughly studied.
J. Kapur +12 more
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Patient Safety, 2021 Medication reconciliation broadly defined includes both formal and informal processes that involve the comprehensive evaluation of a patient’s medications during each transition of care and change in therapy.
Amy Harper +2 more
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Molecules, 2015 A novel series of benzenesulfonamide derivatives containing 4-aminobenzenesul-fonamide and α-amides branched valproic acid or 2,2-dimethylcyclopropanecarboxylic acid moieties were synthesized and screened for their anticonvulsant activities in mice ...
Zhiming Wang +5 more
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Scientia Pharmaceutica, 2023 Mental and neurological disorders are conditions that affect thoughts, emotions, behavior, and relationships. Malpighia mexicana A. Juss. is a plant used in Mexican traditional medicine for the treatment of such disorders.
Dante Avilés-Montes +11 more
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Journal of Biological Chemistry, 2001 Valproic acid is widely used to treat epilepsy and bipolar disorder and is also a potent teratogen, but its mechanisms of action in any of these settings are unknown. We report that valproic acid activates Wntdependent gene expression, similar to lithium,
C. Phiel +5 more
semanticscholar +1 more source
Anticonvulsant Essential Oils and Their Relationship with Oxidative Stress in Epilepsy
Biomolecules, 2019 Epilepsy is a most disabling neurological disorder affecting all age groups. Among the various mechanisms that may result in epilepsy, neuronal hyperexcitability and oxidative injury produced by an excessive formation of free radicals may play a role in ...
Diogo Vilar da Fonsêca +4 more
semanticscholar +1 more source
Epilepsia Open, 2019 Objective The lamotrigine‐resistant amygdala kindling model uses repeated administration of a low dose of lamotrigine during the kindling process to produce resistance to lamotrigine, which also extends to some other antiseizure drugs (ASDs).
Cameron S. Metcalf +5 more
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Salvinorin A Does Not Affect Seizure Threshold in Mice
Molecules, 2020 The κ-opioid receptor has recently gained attention as a new molecular target in the treatment of many psychiatric and neurological disorders including epilepsy.
Katarzyna Socała +2 more
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