Results 11 to 20 of about 128,593 (391)

Bone mineral density, vitamin D and anticonvulsant therapy [PDF]

Arquivos de Neuro-Psiquiatria, 2000
The aim of this study was to assess bone mineral density and vitamin D metabolism in patients on chronic anticonvulsant therapy. METHODS: Sixty-nine men, outpatients on chronic anticonvulsant therapy, who had been treated for at least 5 years, were ...
SILVANA FILARDI, CARLOS A.M. GUERREIRO, LUIS ALBERTO MAGNA, JOÃO FRANCISCO MARQUES NETO   +3 more
doaj   +1 more source

Embryonic Hypotaurine Levels Contribute to Strain-Dependent Susceptibility in Mouse Models of Valproate-Induced Neural Tube Defects

Frontiers in Cell and Developmental Biology, 2022
Valproic acid (VPA, valproate, Depakote) is a commonly used anti-seizure medication (ASM) in the treatment of epilepsy and a variety of other neurological disorders.
John W. Steele, Ying Linda Lin, Nellie Chen, Nellie Chen, Bogdan J. Wlodarczyk, Qiuying Chen, Nabeel Attarwala, Madhu Venkatesalu, Madhu Venkatesalu, Robert M. Cabrera, Steven S. Gross, Richard H. Finnell, Richard H. Finnell, Richard H. Finnell   +13 more
doaj   +1 more source

Randomized Trial of Three Anticonvulsant Medications for Status Epilepticus.

New England Journal of Medicine, 2019
BACKGROUND The choice of drugs for patients with status epilepticus that is refractory to treatment with benzodiazepines has not been thoroughly studied.
J. Kapur, J. Elm, J. Chamberlain, W. Barsan, J. Cloyd, D. Lowenstein, S. Shinnar, R. Conwit, Caitlyn Meinzer, Hannah R Cock, N. Fountain, J. Connor, R. Silbergleit   +12 more
semanticscholar   +1 more source

Searching for New Leads to Treat Epilepsy: Target-Based Virtual Screening for the Discovery of Anticonvulsant Agents [PDF]

, 2018
The purpose of this investigation is to contribute to the development of new anticonvulsant drugs to treat patients with refractory epilepsy. We applied a virtual screening protocol that involved the search into molecular databases of new compounds and ...
Bruno Blanch, Luis Enrique, Enrique, Nicolás Jorge, Gavernet, Luciana, Goicoechea, Sofia, Martín, Pedro, Milesi, Verónica, Palestro, Pablo Hernán, Sabatier, Laureano Leonel, Villalba, Maria Luisa   +8 more
core   +2 more sources

Impaired cognitive ability and anxiety-like behavior following acute seizures in the Theiler's virus model of temporal lobe epilepsy

Neurobiology of Disease, 2014
Viral infection of the CNS can result in encephalitis and acute seizures, increasing the risk for later-life epilepsy. We have previously characterized a novel animal model of temporal lobe epilepsy that recapitulates key sequela in the development of ...
Anthony D. Umpierre, Gregory J. Remigio, E. Jill Dahle, Kate Bradford, Anitha B. Alex, Misty D. Smith, Peter J. West, H. Steve White, Karen S. Wilcox   +8 more
doaj   +1 more source

Patient Harm Resulting From Medication Reconciliation Process Failures: A Study of Serious Events Reported by Pennsylvania Hospitals

Patient Safety, 2021
Medication reconciliation broadly defined includes both formal and informal processes that involve the comprehensive evaluation of a patient’s medications during each transition of care and change in therapy.
Amy Harper, Elizabeth Kukielka, Rebecca Jones   +2 more
doaj   +1 more source

Continuous rate infusion of midazolam as emergent treatment for seizures in dogs

Journal of Veterinary Internal Medicine, 2021
Background Midazolam delivered by continuous rate infusion (CRI) might be effective in dogs with cluster seizures (CS) or status epilepticus (SE). Objective To describe the use and safety of midazolam CRI in dogs with CS or SE.
Kathryn Y. Bray, Christopher L. Mariani, Peter J. Early, Karen R. Muñana, Natasha J. Olby   +4 more
doaj   +1 more source

Effect of different agonistic experiences on behavioural seizures in fully amygdala kindled rats [PDF]

, 1992
Fully amygdala kindled rats were exposed to two different inter-male agonistic experiences in order to study the interaction between epilepsy and acute social stress.
Beldhuis, Hans J.A.,, Bohus, Béla,, Koolhaas, Jaap M.,   +2 more
core   +2 more sources

The Effects of Valproic Acid on Appetitive and Aversive Instrumental Learning in Adult Rats

Frontiers in Behavioral Neuroscience, 2014
Antiepileptic medications are the frontline treatment for seizure conditions. However, these medications are not without cognitive side effects. Previously, our laboratory reported learning deficits in phenytoin and carbamazepine-treated rats.
John Joseph Orczyk, Melissa eBanks, Melissa eBanks, Preston eGarraghty, Preston eGarraghty   +4 more
doaj   +1 more source

Histone Deacetylase Is a Direct Target of Valproic Acid, a Potent Anticonvulsant, Mood Stabilizer, and Teratogen*

Journal of Biological Chemistry, 2001
Valproic acid is widely used to treat epilepsy and bipolar disorder and is also a potent teratogen, but its mechanisms of action in any of these settings are unknown. We report that valproic acid activates Wntdependent gene expression, similar to lithium,
C. Phiel, Fang Zhang, E. Huang, M. Guenther, M. Lazar, P. S. Klein   +5 more
semanticscholar   +1 more source