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The Anticonvulsant Effects of Baldrinal on Pilocarpine-Induced convulsion in Adult Male Mice
Molecules, 2019 Epilepsy is a prevalent neurological disorder that was reported to affect about 56 million people in the world. Approximately one-third of the epileptic patients that suffer from seizures do not receive effective medical treatment.
Xiao Zhang +8 more
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Teratogenic risk and contraceptive counselling in psychiatric practice: analysis of anticonvulsant therapy [PDF]
, 2013 <p>Background: Anticonvulsants have been used to manage psychiatric conditions for over 50 years. It is recognised that some, particularly valproate, carbamazepine and lamotrigine, are human teratogens, while others including topiramate require ...
A Basan +23 more
core +2 more sources
Molecules, 2016 New benztriazoles with a mercapto-triazole and other heterocycle substituents were synthesized and evaluated for their anticonvulsant activity and neurotoxicity by using the maximal electroshock (MES), subcutaneous pentylenetetrazole (scPTZ), and rotarod
Da-Chuan Liu +3 more
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Acetone as an Anticonvulsant [PDF]
Epilepsia, 2008 SummaryRecent interest in the anticonvulsant effects of acetone has stemmed from studies related to the ketogenic diet (KD). The KD, a high‐fat diet used to treat drug‐resistant seizures, raises blood and brain levels of three ketones: beta‐hydroxybutyrate, acetoacetate, and acetone.
W. McIntyre Burnham +2 more
openaire +3 more sources
Frontiers in Pharmacology, 2014 Alpha (α)-asarone, a major effective component isolated from the Chinese medicinal herb Acorus tatarinowii, is clinically used as medication for treating epilepsy, cough, bronchitis, and asthma.
Ze-Jun eWang +3 more
doaj +1 more source
Journal of Enzyme Inhibition and Medicinal Chemistry, 2020 Histamine H3 receptors (H3R) antagonists/inverse agonists are becoming a promising therapeutic approach for epilepsy. In this article, novel nonimidazole H3R antagonists/inverse agonists have been designed and synthesised via hybriding the H3R ...
Mingxia Song +5 more
doaj +1 more source
Clinical considerations in transitioning patients with epilepsy from clonazepam to clobazam: a case series. [PDF]
, 2014 IntroductionIn treating refractory epilepsy, many clinicians are interested in methods used to transition patients receiving clonazepam to clobazam to maintain or increase seizure control, improve tolerability of patients' overall drug therapy regimens ...
Chung, Steve +4 more
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Antiepileptic Drug Discovery and Development: What Have We Learned and Where Are We Going?
Pharmaceuticals, 2010 Current marketed antiepileptic drugs (AEDs) consist of a variety of structural classes with different mechanisms of action. These agents typically have non-overlapping efficacy and side-effect profiles presenting multiple treatment options for the ...
Jeffrey L. Krajewski, Aaron C. Gerlach
doaj +1 more source
Effects Of 4-thiazolidinone Derivatives Les-2658 And Les-1205 On Sleep - Wakefulness Cycle In Kindled Rats [PDF]
, 2017 The research is dedicated to in-depth study of neurotrophic and antiepileptic properties of original potential anticonvulsant agents from 4-thiazolidinones – LES-2658 (5-(3-nitro-benzylidene)-2-(thiazol-2-ylimino)-thiazolidin-4-one) and LES-1205 ([2,4 ...
Lesyk, R. (Roman) +2 more
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Bone mineral density, vitamin D and anticonvulsant therapy [PDF]
Arquivos de Neuro-Psiquiatria, 2000 The aim of this study was to assess bone mineral density and vitamin D metabolism in patients on chronic anticonvulsant therapy. METHODS: Sixty-nine men, outpatients on chronic anticonvulsant therapy, who had been treated for at least 5 years, were ...
SILVANA FILARDI +3 more
doaj +1 more source