Results 31 to 40 of about 124,598 (395)

Inhibitory Effect of Eslicarbazepine Acetate and S-Licarbazepine on Nav1.5 Channels

open access: yesFrontiers in Pharmacology, 2020
Eslicarbazepine acetate (ESL) is a dibenzazepine anticonvulsant approved as adjunctive treatment for partial-onset epileptic seizures. Following first pass hydrolysis of ESL, S-licarbazepine (S-Lic) represents around 95% of circulating active metabolites.
Theresa K. Leslie   +5 more
doaj   +1 more source

Epilepsy in glioma patients: mechanisms, management, and impact of anticonvulsant therapy.

open access: yesNeuro-Oncology, 2016
Seizures are a well-recognized symptom of primary brain tumors, and anticonvulsant use is common. This paper provides an overview of epilepsy and the use of anticonvulsants in glioma patients.
T. Armstrong   +4 more
semanticscholar   +1 more source

The Anticonvulsant Effects of Baldrinal on Pilocarpine-Induced convulsion in Adult Male Mice

open access: yesMolecules, 2019
Epilepsy is a prevalent neurological disorder that was reported to affect about 56 million people in the world. Approximately one-third of the epileptic patients that suffer from seizures do not receive effective medical treatment.
Xiao Zhang   +8 more
doaj   +1 more source

Impaired biotin status in anticonvulsant therapy [PDF]

open access: yes, 1982
In 264 epileptics undergoing long-term therapy with anticonvulsants, significantly reduced plasma biotin levels were found compared with a normal control group: 74% of the epileptics had biotin levels for those treated with sodium valproate were higher ...
Bonjour   +7 more
core   +1 more source

Realising the therapeutic potential of neuroactive steroid modulators of the GABAA receptor [PDF]

open access: yes, 2020
In the 1980s particular endogenous metabolites of progesterone and of deoxycorticosterone were revealed to be potent, efficacious, positive allosteric modulators (PAMs) of the GABAA receptor (GABAAR).
Belelli, Delia   +3 more
core   +1 more source

Synthesis and Biological Evaluation of Novel Benzothiazole Derivatives as Potential Anticonvulsant Agents

open access: yesMolecules, 2016
New benztriazoles with a mercapto-triazole and other heterocycle substituents were synthesized and evaluated for their anticonvulsant activity and neurotoxicity by using the maximal electroshock (MES), subcutaneous pentylenetetrazole (scPTZ), and rotarod
Da-Chuan Liu   +3 more
doaj   +1 more source

Acetone as an Anticonvulsant [PDF]

open access: yesEpilepsia, 2008
SummaryRecent interest in the anticonvulsant effects of acetone has stemmed from studies related to the ketogenic diet (KD). The KD, a high‐fat diet used to treat drug‐resistant seizures, raises blood and brain levels of three ketones: beta‐hydroxybutyrate, acetoacetate, and acetone.
W. McIntyre Burnham   +2 more
openaire   +3 more sources

Identification of both GABAA receptors and voltage-activated Na+ channels as molecular targets of anticonvulsant α-asarone

open access: yesFrontiers in Pharmacology, 2014
Alpha (α)-asarone, a major effective component isolated from the Chinese medicinal herb Acorus tatarinowii, is clinically used as medication for treating epilepsy, cough, bronchitis, and asthma.
Ze-Jun eWang   +3 more
doaj   +1 more source

Design, synthesis, and anticonvulsant effects evaluation of nonimidazole histamine H3 receptor antagonists/inverse agonists containing triazole moiety

open access: yesJournal of Enzyme Inhibition and Medicinal Chemistry, 2020
Histamine H3 receptors (H3R) antagonists/inverse agonists are becoming a promising therapeutic approach for epilepsy. In this article, novel nonimidazole H3R antagonists/inverse agonists have been designed and synthesised via hybriding the H3R ...
Mingxia Song   +5 more
doaj   +1 more source

Neuropeptide receptors as potential antiepileptic drug targets : focus on the ghrelin axis [PDF]

open access: yes, 2014
Epilepsy is a very serious neurological disorder which is often underrepresented. Around 50 million individuals worldwide have active epilepsy with recurrent seizures and in spite of the medical advances over the years, 30% of these patients remain as ...
Portelli, Jeanelle
core   +1 more source

Home - About - Disclaimer - Privacy