Results 31 to 40 of about 86,557 (245)
Therapeutic effects of rosemary (Rosmarinus officinalis L.) and its active constituents on nervous system disorders [PDF]
Iranian Journal of Basic Medical Sciences, 2020 Rosemary (Rosmarinus officinalis L.) is an evergreen bushy shrub which grows along the Mediterranean Sea, and sub-Himalayan areas. In folk medicine, it has been used as an antispasmodic, mild analgesic, to cure intercostal neuralgia, headaches, migraine,
Mahboobeh Ghasemzadeh Rahbardar +1 more
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Bone mineral density, vitamin D and anticonvulsant therapy [PDF]
Arquivos de Neuro-Psiquiatria, 2000 The aim of this study was to assess bone mineral density and vitamin D metabolism in patients on chronic anticonvulsant therapy. METHODS: Sixty-nine men, outpatients on chronic anticonvulsant therapy, who had been treated for at least 5 years, were ...
SILVANA FILARDI +3 more
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Journal of Cannabis Research, 2022 Objective Cannabigerolic acid (CBGA), a precursor cannabinoid in Cannabis sativa, has recently been found to have anticonvulsant properties in the Scn1a +/- mouse model of Dravet syndrome.
Lyndsey L. Anderson +6 more
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Anticonvulsant mechanisms of piperine, a piperidine alkaloid
Channels, 2015 Piperine, a natural compound isolated from the fruits of Piper, is known to modulate several neurotransmitter systems such as serotonin, norepinephrine, and GABA, all of which have been linked to the development of convulsions.
Awanish Mishra +4 more
semanticscholar +1 more source
Reduced Effect of Anticonvulsants on AMPA Receptor Palmitoylation-Deficient Mice
Frontiers in Pharmacology, 2021 AMPA receptors are responsible for fast excitatory synaptic transmission in the mammalian brain. Post-translational protein S-palmitoylation of AMPA receptor subunits GluA1-4 reversibly regulates synaptic AMPA receptor expression, resulting in long ...
Madoka Iizumi +4 more
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Design, Synthesis, and Evaluation of Anticonvulsant Activities of New Triazolopyrimidine Derivatives
Frontiers in Chemistry, 2022 Epilepsy, a severe brain disease affecting a large population, is treated mainly by antiepileptic drugs (AEDs). However, toxicity, intolerance, and low efficiency of the available AEDs have prompted the continual attempts in the discovery of new AEDs. In
Mingxia Song +7 more
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M-current preservation contributes to anticonvulsant effects of valproic acid.
Journal of Clinical Investigation, 2015 Valproic acid (VPA) has been widely used for decades to treat epilepsy; however, its mechanism of action remains poorly understood. Here, we report that the anticonvulsant effects of nonacute VPA treatment involve preservation of the M-current, a low ...
Hee Yeon Kay +4 more
semanticscholar +1 more source
The Effects of Valproic Acid on Appetitive and Aversive Instrumental Learning in Adult Rats
Frontiers in Behavioral Neuroscience, 2014 Antiepileptic medications are the frontline treatment for seizure conditions. However, these medications are not without cognitive side effects. Previously, our laboratory reported learning deficits in phenytoin and carbamazepine-treated rats.
John Joseph Orczyk +4 more
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Tetrazolium Compounds: Synthesis and Applications in Medicine
Molecules, 2015 Tetrazoles represent a class of five-membered heterocyclic compounds with polynitrogen electron-rich planar structural features. This special structure makes tetrazole derivatives useful drugs, explosives, and other functional materials with a wide range
Cheng-Xi Wei, Ming Bian, Guo-Hua Gong
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Frontiers in Veterinary Science, 2022 Potassium bromide is a frequently used antiseizure medication with a half-life time of over 25 days. Oral intake of sodium chloride as well as renal function influence this half-life time and may have an influence on the needed dose to get proper serum ...
Esther A. Lichtenauer +4 more
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