Results 31 to 40 of about 47,218 (298)
Reduced Effect of Anticonvulsants on AMPA Receptor Palmitoylation-Deficient Mice
Frontiers in Pharmacology, 2021 AMPA receptors are responsible for fast excitatory synaptic transmission in the mammalian brain. Post-translational protein S-palmitoylation of AMPA receptor subunits GluA1-4 reversibly regulates synaptic AMPA receptor expression, resulting in long ...
Madoka Iizumi +4 more
doaj +1 more source
Pain‐autonomic measures reveal nociceptive sensitization in complex regional pain syndrome
European Journal of Pain, Volume 27, Issue 1, Page 72-85, January 2023., 2023 Abstract Background Allodynia and hyperalgesia are common signs in individuals with complex regional pain syndrome (CRPS), mainly attributed to sensitization of the nociceptive system. Appropriate diagnostic tools for the objective assessment of such hypersensitivities are still lacking, which are essential for the development of mechanism‐based ...
Paulina S. Scheuren +5 more
wiley +1 more source
Recent developments on triazole nucleus in anticonvulsant compounds: a review
Journal of Enzyme Inhibition and Medicinal Chemistry, 2018 Epilepsy is one of the common diseases seriously threatening life and health of human. More than 50 million people are suffering from this condition and anticonvulsant agents are the main treatment.
Ming-Xia Song, Xian-Qing Deng
doaj +1 more source
Design, Synthesis, and Evaluation of Anticonvulsant Activities of New Triazolopyrimidine Derivatives
Frontiers in Chemistry, 2022 Epilepsy, a severe brain disease affecting a large population, is treated mainly by antiepileptic drugs (AEDs). However, toxicity, intolerance, and low efficiency of the available AEDs have prompted the continual attempts in the discovery of new AEDs. In
Mingxia Song +7 more
doaj +1 more source
Role of acid‐base and hydration‐dehydration equilibria on reductions of chloral and chloral hydrate
Electrochemical Science Advances, Volume 2, Issue 6, December 2022., 2022 Abstract The electrochemical behavior of chloral hydrate in aqueous solutions at various pH values was investigated by using polarography. Reduction of chloral hydrate takes place in two steps: one appears as a small limiting current value that corresponds to the reduction of the unhydrated form, present in solutions in less than 3%, and another larger
Melek Sirin Baymak
wiley +1 more source
The Effects of Valproic Acid on Appetitive and Aversive Instrumental Learning in Adult Rats
Frontiers in Behavioral Neuroscience, 2014 Antiepileptic medications are the frontline treatment for seizure conditions. However, these medications are not without cognitive side effects. Previously, our laboratory reported learning deficits in phenytoin and carbamazepine-treated rats.
John Joseph Orczyk +4 more
doaj +1 more source
Tetrazolium Compounds: Synthesis and Applications in Medicine
Molecules, 2015 Tetrazoles represent a class of five-membered heterocyclic compounds with polynitrogen electron-rich planar structural features. This special structure makes tetrazole derivatives useful drugs, explosives, and other functional materials with a wide range
Cheng-Xi Wei, Ming Bian, Guo-Hua Gong
doaj +1 more source
Frontiers in Veterinary Science, 2022 Potassium bromide is a frequently used antiseizure medication with a half-life time of over 25 days. Oral intake of sodium chloride as well as renal function influence this half-life time and may have an influence on the needed dose to get proper serum ...
Esther A. Lichtenauer +4 more
doaj +1 more source
Exposing Hidden Alternative Conformations of Small Flexible Molecules in 2D NMR Spectroscopy Using 1H-15N HMBC [PDF]
arXiv, 2020 Two-dimensional 1H-15N HMBC NMR spectra of a well-known anticonvulsant-carbamazepine-dissolved in chloroform, recorded on an NMR spectrometer and obtained from quantum-chemical calculations prove the existence of hidden conformers in saturated solutions.
arxiv
Progressive Myoclonus Epilepsy: Distinctive MRI Changes in Cerebellar and Motor Networks
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objective Progressive myoclonus epilepsy (PME) is a rare generalized epilepsy syndrome with a well‐characterized genetic basis. The brain networks that are affected to give rise to the distinctive symptoms of PME are less well understood. Methods Eleven individuals with PME with a confirmed genetic diagnosis and 22 controls were studied.
Jillian M. Cameron +3 more
wiley +1 more source