Results 71 to 80 of about 47,218 (298)

Reactive microglia are the major source of tumor necrosis factor alpha and contribute to astrocyte dysfunction and acute seizures in experimental temporal lobe epilepsy

Glia, Volume 71, Issue 2, Page 168-186, February 2023., 2023
Main Points Microglia become rapidly reactive in temporal lobe epilepsy (TLE). Microglia are major producers of TNFα during status epilepticus, which impairs astrocyte coupling and promotes gliosis. Depletion of microglia attenuates acute seizure activity in TLE.
Lukas Henning, Henrike Antony, Annika Breuer, Julia Müller, Gerald Seifert, Etienne Audinat, Parmveer Singh, Frederic Brosseron, Michael T. Heneka, Christian Steinhäuser, Peter Bedner   +10 more
wiley   +1 more source

Immediate Therapeutic Response to Vigabatrin in Lissencephaly‐Related Epileptic Spasms due to TUBA1A R402H Variant

American Journal of Medical Genetics Part A, EarlyView.
Toru Nagata, Takashi Shibata, Hiroki Tsuchiya, Mari Akiyama, Mitsuhiro Kato, Tomoyuki Akiyama, Toshiki Takenouchi   +6 more
wiley   +1 more source

Mapping Interictal activity in epilepsy using a hidden Markov model: A magnetoencephalography study

Human Brain Mapping, Volume 44, Issue 1, Page 66-81, January 2023., 2023
In this study, we use hidden Markov modeling (HMM) to create a unique statistical model of interictal brain activity for 10 pediatric epilepsy patients. This data‐driven model produces an output unique to each patient, and is used to localize the epileptogenic area(s).
Zelekha A. Seedat, Lukas Rier, Lauren E. Gascoyne, Harry Cook, Mark W. Woolrich, Andrew J. Quinn, Timothy P. L. Roberts, Paul L. Furlong, Caren Armstrong, Kelly St. Pier, Karen J. Mullinger, Eric D. Marsh, Matthew J. Brookes, William Gaetz   +13 more
wiley   +1 more source

Phyto-pharmacological review of Portulaca quadrifida Linn.

Journal of Applied Pharmaceutical Research, 2013
Portulaca quadrifida Linn. (Family: Portuleacea), commonly known as “Chicken Weed”, a traditional medicinal plant has been used in the Ayurvedic system of medicine for centuries, valued for its benefits in the management of urinary and inflammatory ...
Mrinmay Das, Ashok Kumar D.
doaj  

5‐Aza combined with VPA reprograms human T lineage acute leukemia Jurkat cells into B‐cell‐like cells by epigenetic activation of PAX5

Biotechnology Progress, EarlyView.
Abstract Epigenetic regulation plays an important role in cell fate reprogramming. Here, we found that inhibitors of epigenetic modifiers, including VPA, TSA, and 5‐Aza‐2'‐deoxycytidine, can induce phenotypic transformation from Jurkat cells into B‐cell‐like cells. When Jurkat cells were treated with 5‐Aza combined with VPA, B cell and stem cell marker
Wenjin Xi, Guoxu Zheng, Xu Chen, Baile Zuo, Wei Wang, Yufang Li, Chunmei Zhang, Jie Chu, Xiuli Mu, Weihong Wen, Tao Wang, An‐Gang Yang   +11 more
wiley   +1 more source

More cost‐sharing, less cost? Evidence on reference price drugs

Health Economics, Volume 32, Issue 2, Page 413-435, February 2023., 2023
Abstract This paper evaluates the causal effects of changes in reference prices (RP) on prices, copayments, and overall expenditures for off‐patent pharmaceuticals. With reference pricing, firms set prices freely and the health plan covers the expenses only up to a certain threshold. We use quarterly data of the German market for anti‐epileptics at the
Annika Herr, Torben Stühmeier, Tobias Wenzel   +2 more
wiley   +1 more source

Nerve agents: A clear and present danger to mankind [PDF]

Scripta Medica, 2019
This editorial is written on the occasion of the 25th anniversary of the infamous sarin and VX terrorist attacks in Japan, in order to increase the awareness of the potential terrorist use of nerve agents and to urge the preparedness to cope with its ...
Stojiljković Miloš P.
doaj  

Fused Nitrogen Bridgehead N,O‐Acetals as Versatile Scaffolds: Synthetic Strategies, Mechanism and Applications

Chemistry – A European Journal, Accepted Article.
Fused Bicyclic N,O‐acetals, are prominently present in several natural products and constitute a versatile family of compounds, with nitrogen‐bridgehead fused N,O‐bicyclic derivatives receiving specific emphasis as pivotal scaffolds due to their significant role in the bioactivity of medicinally relevant molecules.
Alexis D. Kouvelas, Michael G. Kallitsakis, Ioannis N. Lykakis   +2 more
wiley   +1 more source

Anticonvulsant activity of Nigella sativa, Aegle marmelos and Benincasa hispida in Pentylenetetrazole induced seizure in Swiss albino mice

Asian Journal of Medical Sciences, 2016
Aims and Objectives: To test anticonvulsant properties of three medicinal plants with pentylenetetrazole induced seizure test in Swiss albino mice. Materials and Methods: Herbs selected for the work (leaves of Aegle marmelos, seed of Nigella sativa ...
Rejeesh Edavan Puthallath
doaj   +1 more source

Isoniazid‐Dihydropyrimidinone Molecular Hybrids: Design, Synthesis, Antitubercular Activity, and Cytotoxicity Investigations with Computational Validation

ChemMedChem, EarlyView.
Antitubercular evaluation of a novel library of isoniazid‐dihydropyrimidinone molecular hybrids (8a–8n) discloses a potent compound with MIC = 0.39μg mL−1 against M. tuberculosis mc26230. Cytotoxicity, stability, and in silico studies, including molecular docking and ADME/T (absorption, distribution, metabolism, excretion, and toxicity) analysis ...
Gobind Kumar, Pule Seboletswe, Sahil Mishra, Neha Manhas, Safiyah Ghumran, Nagaraju Kerru, Françoise Roquet‐Banères, Maëlle Foubert, Laurent Kremer, Gaurav Bhargava, Parvesh Singh   +10 more
wiley   +1 more source