Results 21 to 30 of about 10,863 (191)
Models of Depression: Unpredictable Chronic Mild Stress in Mice
Current Protocols, Volume 1, Issue 8, August 2021., 2021 Abstract Major depression is a complex psychiatric disorder characterized by affective, cognitive, and physiological impairments that lead to maladaptive behavior. The high lifetime prevalence of this disabling condition, coupled with limitations of existing medications, make necessary the development of improved therapeutics.
Mathieu Nollet
wiley +1 more source
International Journal of Geriatric Psychiatry, Volume 36, Issue 6, Page 917-925, June 2021., 2021 Abstract Objectives We aim to study the effects of the prescription of benzodiazepines and antidepressants on cognitive and functional decline in older adults living with Alzheimer's disease (AD) and Lewy body dementia (LBD) over a 5‐year follow‐up.
Miguel Germán Borda +8 more
wiley +1 more source
Effectiveness of a recent topical sialogogue in the management of drug-induced xerostomia [PDF]
, 2011 Objectives: Use of certain drugs is the most common aetiology of xerostomia. Systemic sialogogues provide a longer effect than topic ones, but also induce relevant side effects. Topical sialogogues, as malic acid, allow a safe use as they
Aguilar Salvatierra, Antonio +3 more
core +1 more source
Network reconstruction of platelet metabolism identifies metabolic signature for aspirin resistance. [PDF]
, 2014 Recently there has not been a systematic, objective assessment of the metabolic capabilities of the human platelet. A manually curated, functionally tested, and validated biochemical reaction network of platelet metabolism, iAT-PLT-636, was reconstructed
Bordbar, Aarash +4 more
core +2 more sources
Hipertensão arterial sistêmica e depressão [PDF]
, 2005 Despite the high prevalence of depression and hypertension, the relationship between the two diseases has received little attention. This paper reviews the epidemiological, pathophysiological, and prognostic aspects of this association, as well as its ...
Azul, João Batista Serro +3 more
core +3 more sources
Mirtazapine decreases stimulatory effects of reboxetine on cortisol, adrenocorticotropin and prolactin secretion in healthy male subjects [PDF]
, 2004 Reboxetine is a selective noradrenaline reuptake inhibitor, whereas mirtazapine acts as an antagonist at noradrenergic alpha(2), serotonin (5-HT2), 5-HT3 and histamine H-1 receptors.
Baghai, Thomas C. +2 more
core +1 more source
Pharmacological treatment of depression in people with a primary brain tumour [PDF]
, 2020 Background This is the second updated version of the Cochrane Review published in Issue 3, 2010 and first updated in Issue 5, 2013. People with a primary brain tumour oGen experience depression, for which drug treatment may be prescribed.
Beevers, Z +3 more
core +1 more source
Journal of Psychiatry SpectrumBackground: Dementia is associated with a complex array of neuropsychiatric manifestations which require consideration as they worsen the course of illness, especially in neurodegenerative etiologies.
R. Shantheri Pai +2 more
doaj +1 more source
Use of antidepressants and the risk of myocardial infarction in middle-aged and older adults: A matched case-control study [PDF]
, 2016 Purpose: Antidepressants, specifically selective serotonin reuptake-inhibiting antidepressants (SSRIs), decrease platelet activation and aggregation in in vitro experiments and could therefore decrease the risk of myocardial infarction (MI).
Aarts, N. (Nikkie) +7 more
core +2 more sources
MedComm, Volume 6, Issue 5, May 2025.Reactive astrocytes release various molecules, which play a role in maintaining central nervous system (CNS) homeostasis. (1) Gliotransmitters, such as glutamate, γ‐aminobutyric acid (GABA), ATP, and D‐serine, are secreted by vesicular exocytosis. In addition, astrocytes can also release ATP and glutamate through (2) P2X7Rs, (3) connexin‐43 (Cx43 ...
Peter Illes +4 more
wiley +1 more source