Results 11 to 20 of about 98,828 (291)

Design, Docking, Synthesis, and Biological Evaluation of Pyrazolone Derivatives as Potential Dual-Action Antimicrobial and Antiepileptic Agents [PDF]

Pharmaceuticals
Background/Objectives: Epilepsy is characterized by unpredictable seizures and drug resistance, along with rising antimicrobial resistance (AMR), highlighting the urgent need for innovative dual-action therapies.
Yousef Al-ebini, Manojmouli Chandramouli, Naga Prashant Koppuravuri, Thoppalada Yunus Pasha, Mohamed Rahamathulla, Salwa Eltawaty, Kamal Y. Thajudeen, Mohammed Muqtader Ahmed, Thippeswamy Boreddy Shivanandappa   +8 more
doaj   +2 more sources

Increased expression of galanin and its receptors in the dorsal hippocampus during epileptogenesis in a rat model of pilocarpine-induced temporal lobe epilepsy

Stress and Brain, 2023
Background:The neuropeptide galanin has been shown to exhibit anticonvulsant effects in animal models. However, only a few studies have attempted to identify the galanin receptor subtype (s) involved in this effect.
Jing Sun, Shu Xu, Xiaoxiao Li, Tianyi Li, Changqing Liu, Jian Zhou, Guoming Luan, Zhiqing Xu   +7 more
doaj   +1 more source

Investigation of the Antiepileptics on Levels of Vitamin D and Calcium

Acta Medica Alanya, 2022
Aim: We investigated the connection between D vitamin and factors such as the type of antiepileptic agent, patient age and gender.Methods: This retrospective case-control study enrolled a total of 301 participants, including 141 epilepsy patients with (n=
Burak Yuluğ, Ece Özdemir Öktem, Ahmet Özşimşek   +2 more
doaj   +1 more source

The role of astrocytes in epileptic disorders

Physiological Reports, 2022
Epilepsy affects about 1% of the population and approximately 30% of epileptic patients are resistant to current antiepileptic drugs. As a hallmark in epileptic tissue, many of the epileptic patients show changes in glia morphology and function.
Parichehr Hayatdavoudi, Mahmoud Hosseini, Vahid Hajali, Azar Hosseini, Arezoo Rajabian   +4 more
doaj   +1 more source

Use of Cyclosporine for the Treatment of Stevens- Johnson syndrome and Toxic Epidermal Necrolysis Induced by Carbamazepine- A Case Report [PDF]

Journal of Clinical and Diagnostic Research, 2023
Stevens Johnson syndrome (SJS) and Toxic Epidermal Necrolysis (TEN) are rare, potentially life threatening, severe mucocutaneous adverse reactions characterised by extensive epidermal detachment, erosion of mucosa and severe constitutional symptoms ...
Sanket G Malu, Ravindra S Beedimani, Santoshkumar R Jeevanagi   +2 more
doaj   +1 more source

Levetirazetam: antiepileptic-induced psychosis

European Psychiatry, 2022
Introduction Levetirazetam is an antiepileptic drug with psychiatric adverse reactions. It includes psychosis, paranoia or hallucinations. The frequency is less than 1%.
C. Vilella Martín, P. García Vázquez, Y. Barrera García, P. Fernández Perea, A. Serrano García, M.Á. Alonso De La Torre López, R. Gómez Martínez, C. Franch Pato   +7 more
doaj   +1 more source

Embryonic Hypotaurine Levels Contribute to Strain-Dependent Susceptibility in Mouse Models of Valproate-Induced Neural Tube Defects

Frontiers in Cell and Developmental Biology, 2022
Valproic acid (VPA, valproate, Depakote) is a commonly used anti-seizure medication (ASM) in the treatment of epilepsy and a variety of other neurological disorders.
John W. Steele, Ying Linda Lin, Nellie Chen, Nellie Chen, Bogdan J. Wlodarczyk, Qiuying Chen, Nabeel Attarwala, Madhu Venkatesalu, Madhu Venkatesalu, Robert M. Cabrera, Steven S. Gross, Richard H. Finnell, Richard H. Finnell, Richard H. Finnell   +13 more
doaj   +1 more source

The epidemiology of afebrile seizures in the pediatric population of the Trans-Baikal Territory

Неврология, нейропсихиатрия, психосоматика, 2016
Objective: to study the epidemiology of afebrile seizures (ASs) in the pediatric  population of the Trans-Baikal Territory in 2004 to 2013.Patients and methods.
N. A. Marueva, N. A. Shnaider, A. V. Shulmin, Yu. A. Shirshov, G. A. Goltvanitsa, E. V. Leontyeva   +5 more
doaj   +1 more source

Clemizole and trazodone are effective antiseizure treatments in a zebrafish model of STXBP1 disorder

Epilepsia Open, 2022
CRISPR‐Cas9–generated zebrafish carrying a 12 base‐pair deletion in stxbpb1b, a paralog sharing 79% amino acid sequence identity with human, exhibit spontaneous electrographic seizures during larval stages of development.
Maia Moog, Scott C. Baraban
doaj   +1 more source

The 4-Aminopyridine Model of Acute Seizures in vitro Elucidates Efficacy of New Antiepileptic Drugs [PDF]

, 2019
Up to date, preclinical screening for new antiepileptic substances is performed by a combination of different in vivo models of acute seizures, for which large numbers of animals are necessary.
Dag, Ramazan, Fidzinski, Pawel, Heuzeroth, Hanno, Holtkamp, Martin, Wawra, Matthias   +4 more
core   +1 more source