Profile of once-daily zonisamide as monotherapy for treatment of partial seizures in adults. [PDF]
, 2013 Epilepsy is one of the most common neurologic disorders, affecting about 50 million people around the world. It is recognized that around 50% of patients with newly diagnosed epilepsy become seizure-free with the first drug treatment, so the choice of ...
Mula, M
core +3 more sources
Evaluation of antiepileptic activity of the methanol extract of Trachyspermum ammi (L.) [PDF]
Archives of Biological Sciences, 2013 This study aims to investigate the effect of a methanol extract of Trachyspermum ammi (L.) as an antiepileptic agent. Tests were conducted with a single- and multiple-dosing schedule of Trachyspermum ammi (L.), using a strychnine-induced seizure model
Rajput Muhammad Ali +2 more
doaj +1 more source
Long-term effect of antiepileptic drug switch on serum lipids and C-reactive protein. [PDF]
, 2016 BACKGROUND: Prior studies have shown that switching patients from inducing antiepileptic drugs (AEDs) to lamotrigine, levetiracetam, or topiramate reduces serum lipids and C-reactive protein (CRP). These studies were all of short duration, and some drugs,
Chervoneva, Inna +6 more
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Neuropeptide receptors as potential antiepileptic drug targets : focus on the ghrelin axis [PDF]
, 2014 Epilepsy is a very serious neurological disorder which is often underrepresented. Around 50 million individuals worldwide have active epilepsy with recurrent seizures and in spite of the medical advances over the years, 30% of these patients remain as ...
Portelli, Jeanelle
core +1 more source
Efficacy and tolerability of adjunctive brivaracetam in patients with prior antiepileptic drug exposure: A post-hoc study. [PDF]
, 2017 Brivaracetam (BRV), a selective, high-affinity ligand for synaptic vesicle protein 2A, is a new antiepileptic drug (AED) for adjunctive treatment of focal (partial-onset) seizures in adults with epilepsy.
Asadi-Pooya, Ali A. +7 more
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Carbamazepine-induced Life-threatening Stevens-Johnson Syndrome and Agranulocytosis: The Maiden Case [PDF]
Journal of Clinical and Diagnostic Research, 2016 Stevens-Johnson syndrome is one of the few dermatological emergencies in clinical practice. The syndrome is often secondary to the usage of drugs, of which allopurinol, penicillins, sulfa drugs, ibuprofen, sodium valproate, phenytoin, lamotrigine and ...
A. Avinash +4 more
doaj +1 more source
Frontiers in Pharmacology, 2022 Background: Evidence from developed countries demonstrates that the use of antiseizure medications (ASMs) has been increasing in the last decade. Pregnant women have a very challenging risk benefit trade-off in terms of ASM utilization, and it is crucial
Walid Shouman +14 more
doaj +1 more source
New insights into the mechanisms and sites of action of lamotrigine [PDF]
, 2000 This study was aimed at investigating the effects of lamotrigine (LTG) on electrically evoked field excitatory postsynaptic potentials (fEPSP) and population spikes in the CA1 hippocampal region of guinea pigs.
Grunze, Heinz +3 more
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Transient epileptic amnesia: an emerging late-onset epileptic syndrome. [PDF]
, 2009 Transient epileptic amnesia (TEA) is a distinct neurologic condition occurring in late-middle/old age and presenting with amnesic attacks of epileptic nature and interictal memory disturbances.
BILO, LEONILDA +4 more
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The Effects of Valproic Acid on Appetitive and Aversive Instrumental Learning in Adult Rats
Frontiers in Behavioral Neuroscience, 2014 Antiepileptic medications are the frontline treatment for seizure conditions. However, these medications are not without cognitive side effects. Previously, our laboratory reported learning deficits in phenytoin and carbamazepine-treated rats.
John Joseph Orczyk +4 more
doaj +1 more source