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Antiepileptic Drugs in Pediatrics
2019Epilepsy affects approximately 1% of the population. First-line treatment for epilepsy is the administration of anti-seizure medication, also referred to as antiepileptic drugs (AEDs), although this nomenclature is erroneous as these medications typically do not impact underlying epileptogenic processes; the goal of these medications is to control ...
Tesfaye, Zelleke +3 more
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Interactions of Antiepileptic Drugs
Epilepsia, 1975SUMMARYSeveral interactions involving antiepileptic drugs are based on changes in the rate of their metabolism and elimination, with concomitant rise or fall of plasma levels. Thus, phenobarbital generally induces the production of the DPH metabolizing enzyme, but its presence inhibits the action of that enzyme.
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[Antiepileptic drugs and carnitine].
Revista de neurologia, 2000Carnitine is an nonproteic nitrogenated compound acid present in all mammalian tissue and its principal activity is the long-chain fatty acid transport across the mitochondrial membrane for beta-oxidation.Carnitine levels are maintained by absorption from dietary, endogenous synthesis in the liver and renal reabsorption.
Campistol J +3 more
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Pharmacological Research, 1995
Notwithstanding pharmacokinetics has greatly increased the rational approach to the drug treatment of epilepsies, about 25% of the patients do not respond to the therapy. Therefore, a great effort has been made to discover new antiepileptic drugs effective in refractory seizures.
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Notwithstanding pharmacokinetics has greatly increased the rational approach to the drug treatment of epilepsies, about 25% of the patients do not respond to the therapy. Therefore, a great effort has been made to discover new antiepileptic drugs effective in refractory seizures.
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Antiepileptic Drugs and the Electroencephalogram
Epilepsia, 1987Summary: : The usefulness of electroencephalography (EEG) as an aid to diagnosis of seizure disorders is established, but its role as a guide to monitoring treatment is much less certain. For those patients with classical absences and 3‐s spike wave activity there is a very close correlation between control of clinically detected seizures and EEG ...
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ANTIEPILEPTIC DRUGS | Antiepileptic Drug Mechanisms
2009T.A. Simeone, J.M. Rho
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Therapeutic drug monitoring of antiepileptic drugs: current status and future prospects
Expert Opinion on Drug Metabolism and Toxicology, 2020Svein I Johannessen +2 more
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