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Interactions with Antiepileptic Drugs
Drugs, 1977Most of the currently available antiepileptic drugs have a low therapeutic ratio and therefore a drug interaction causing elevation of the serum level of one of these compounds can readily lead to drug intoxication. Phenytoin, in particular, is vulnerable because its metabolism is dose-related and at therapeutic serum levels the enzyme system involved ...
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Determination of antiepileptic drugs
Journal of Chromatography B: Biomedical Sciences and Applications, 1985The present paper reviews gas and liquid chromatographic methods for the determination of the most commonly monitored antiepileptic drugs: phenobarbital, phenytoin, carbamazepine, primidone, ethosuximide, valproic acid and clonazepam along with a new compound, progabide. The individual classes of drugs are first treated separately to highlight specific
J T, Burke, J P, Thénot
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Clinical Pharmacokinetics, 1979
In an open prospective clinical study, plasma clearance of phenytoin, phenobarbitone and carbamazepine was assessed in 14 epileptic patients during and after pregnancy. Plasma clearance showed a marked increase during pregnancy, reached a maximum just before or after delivery, and then decreased to early pregnancy values.
M, Dam +3 more
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In an open prospective clinical study, plasma clearance of phenytoin, phenobarbitone and carbamazepine was assessed in 14 epileptic patients during and after pregnancy. Plasma clearance showed a marked increase during pregnancy, reached a maximum just before or after delivery, and then decreased to early pregnancy values.
M, Dam +3 more
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Contraception and Antiepileptic Drugs
Journal of Midwifery & Women's Health, 2012Epilepsy is a neurologic condition that affects women and women's choices in many areas of their lives. Some antiepileptic drugs (AEDs) used in the treatment of epilepsy can interact with hormonal contraceptives. The result can be decreased effectiveness in the contraceptive with the possibility of unintended pregnancy, or decreased effectiveness of ...
Taasha, Guillemette, Susan M, Yount
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Antiepileptic Drug Pharmacogenetics
Therapeutic Drug Monitoring, 2000Until recently, the drug treatment of epilepsy has been empirical. However, in recent years as a result of improved understanding of seizure neurochemistry and mechanisms of action of antiepileptic drugs (AEDs), drug treatment has become somewhat more rational.
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Antiepileptic drugs in adolescents
Journal of Adolescent Health Care, 1987Adolescence is a critical developmental period in which major metabolic changes occur. The majority of adolescents with epilepsy can be fully controlled with medications and can lead productive lives. A knowledge of basic principles of pharmacotherapy with AEDs will enable the physician to treat effectively most adolescents with epilepsy.
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Antiepileptic drugs and suicidality
Journal of Psychopharmacology, 2012The current study is a systematic review of the literature concerning the possible relationship of antiepileptics and suicide-related clinical features and behaviours. A MEDLINE search returned 863 papers but only five were chosen as relevant. A critical analysis of the Food and Drug Administration report is also included.
Konstantinos N, Fountoulakis +6 more
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Archives of disease in childhood - Education & practice edition, 2007
The aim of this review is to describe the properties and uses of the more recently available anticonvulsant agents. The goal of epilepsy treatment is to achieve total seizure freedom with no side effects. Despite the appropriate use of anticonvulsants approximately 25% of children will continue to experience seizures.
S, Macleod, R E, Appleton
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The aim of this review is to describe the properties and uses of the more recently available anticonvulsant agents. The goal of epilepsy treatment is to achieve total seizure freedom with no side effects. Despite the appropriate use of anticonvulsants approximately 25% of children will continue to experience seizures.
S, Macleod, R E, Appleton
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Pharmacokinetics of antiepileptic drugs
Neurology, 1998Enzymatic biotransformation is the principal determinant of the pharmacokinetic properties of most antiepileptic drugs (AEDs), although some agents are excreted by the kidneys predominantly as unchanged drug. Most AEDs exhibit linear enzyme kinetics, in which changes in daily dose lead to proportional changes in serum concentration if clearance remains
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Antiepileptic drugs and memory
Epilepsy & Behavior, 2004Impaired memory is among the most common complaints of patients with epilepsy. Multiple factors contribute to memory impairment in patients with epilepsy. Thus, delineation of the effects of antiepileptic drugs (AEDs) on memory in clinical populations faces methodological difficulties.
Gholam K, Motamedi, Kimford J, Meador
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