Results 11 to 20 of about 645,736 (382)
Metabolites, 2020 We reviewed the licensed antifungal drugs and summarized their mechanisms of action, pharmacological profiles, and susceptibility to specific fungi. Approved antimycotics inhibit 1,3-β-d-glucan synthase, lanosterol 14-α-demethylase, protein, and deoxyribonucleic acid biosynthesis, or sequestrate ergosterol.
Jiří Houšť +2 more
openaire +5 more sources
Tackling the emerging threat of antifungal resistance to human health
Nature Reviews Microbiology, 2022 Invasive fungal infections pose an important threat to public health and are an under-recognized component of antimicrobial resistance, an emerging crisis worldwide.
M. Fisher +19 more
semanticscholar +1 more source
Molecular mechanisms governing antifungal drug resistance
npj antimicrobials and resistance, 2023 Fungal pathogens are a severe public health problem. The leading causative agents of systemic fungal infections include species from the Candida, Cryptococcus, and Aspergillus genera.
Yunjin Lee, Nicole Robbins, L. Cowen
semanticscholar +1 more source
The Antifungal Pipeline: Fosmanogepix, Ibrexafungerp, Olorofim, Opelconazole, and Rezafungin
Drugs, 2021 The epidemiology of invasive fungal infections is changing, with new populations at risk and the emergence of resistance caused by the selective pressure from increased usage of antifungal agents in prophylaxis, empiric therapy, and agriculture.
M. Hoenigl +11 more
semanticscholar +1 more source
Chitosan and Chitosan Nanoparticles: Parameters Enhancing Antifungal Activity
Molecules, 2023 Chitosan (CS), a biopolymer derived from chitin, is known for strong antifungal activity while being biodegradable, biocompatible, and non-toxic. Because of its characteristic it has been widely used in control of fungal pathogens. Antifungal activity of
P. Poznański, A. Hameed, W. Orczyk
semanticscholar +1 more source
The Potential of Fatty Acids and Their Derivatives as Antifungal Agents: A Review
Toxins, 2022 Fungal contamination presents several problems: in humans, health issues arise from infections with opportunistic filamentous fungi and yeast, while in food, fungi cause spoilage and, in particular, in the case of mycotoxigenic fungi, can cause serious ...
Ana Guimarães, A. Venâncio
semanticscholar +1 more source
Antifungal Drug Resistance: Molecular Mechanisms in Candida albicans and Beyond.
Chemical Reviews, 2020 Fungal infections are a major contributor to infectious disease-related deaths across the globe. Candida species are among the most common causes of invasive mycotic disease, with Candida albicans reigning as the leading cause of invasive candidiasis ...
Yunjin Lee +3 more
semanticscholar +1 more source
Microbial volatile organic compounds: Antifungal mechanisms, applications, and challenges
Frontiers in Microbiology, 2022 The fungal decay of fresh fruits and vegetables annually generates substantial global economic losses. The utilization of conventional synthetic fungicides is damaging to the environment and human health.
Xixi Zhao +3 more
semanticscholar +1 more source
Emerging Antifungal Targets and Strategies
International Journal of Molecular Sciences, 2022 Despite abundant research in the field of antifungal drug discovery, fungal infections remain a significant healthcare burden. There is an emerging need for the development of novel antifungals since those currently available are limited and do not ...
Marija Ivanov +2 more
semanticscholar +1 more source
Candida auris: Epidemiology, biology, antifungal resistance, and virulence
PLoS Pathogens, 2020 First described in 2009 in Japan, the emerging multidrug-resistant fungal pathogen Candida auris is becoming a worldwide public health threat that has been attracting considerable attention due to its rapid and widespread emergence over the past decade ...
Han Du +5 more
semanticscholar +1 more source