Results 91 to 100 of about 327,504 (360)

Repurposing of terconazole as an anti Trypanosoma cruzi agent [PDF]

, 2019
Trypanosoma cruzi is the causative agent of Chagas disease, a parasitic infection endemic in Latin America. Currently there are no effective treatments for the chronic phase of the disease, when most patients are diagnosed, therefore the development of ...
Martínez Sayé, Melisa Soledad, Miranda, Mariana Reneé, Pereira, Claudio Alejandro, Reigada, Chantal, Valera Vera, Edward Augusto   +4 more
core   +1 more source

Decellularized Extracellular Matrix Scaffolds to Engineer the Dormant Landscape of Microscopic Colorectal Cancer Liver Metastasis

Advanced Healthcare Materials, EarlyView.
Decellularized liver extracellular matrix scaffolds provide a platform to study dormant liver‐metastatic colorectal cancer. They induce reversible dormancy, in combination with nutrient depletion and low dose chemotherapy, through cell cycle arrest and chemotherapy resistance.
Sabrina N. VandenHeuvel, Lucia L. Nash, Abigail J. Clevenger, Claudia A. Collier, Oscar R. Benavides, Sanjana Roy, Brinlee Goggans, Aelita Salikhova, Anvitha Tharakesh, Svasti Haricharan, Amber N. Stratman, Scott Kopetz, Alex J. Walsh, Shreya A. Raghavan   +13 more
wiley   +1 more source

Antifungal Agents: Design, Synthesis, Antifungal Activity and Molecular Docking of Phloroglucinol Derivatives

Molecules, 2018
Pseudoaspidinol is a phloroglucinol derivative with Antifungal activity and is a major active component of Dryopteris fragrans. In our previous work, we studied the total synthesis of pseudoaspidinol belonging to a phloroglucinol derivative and ...
Xingxing Teng, Yuanyuan Wang, Jinhua Gu, Peiqi Shi, Zhibin Shen, Lianbao Ye   +5 more
doaj   +1 more source

Green synthesis of highly functionalized octahydropyrrolo[3,4-c]pyrrole derivatives using subcritical water, and their anti(myco)bacterial and antifungal activity [PDF]

, 2018
A series of novel 2-(thiazol-2-yl)-octahydropyrrolo[3,4-c]pyrroles was synthesized by reaction of octahydropyrrolo[3,4-c]pyrrole N-benzoylthiourea derivatives and α-haloketones in subcritical water at 130 °C in 75-91% yield.
De Coen, Laurens, Gemili, Muge, Nural, Yahya, Ulger, Mahmut, Yabalak, Erdal   +4 more
core   +1 more source

A Human Kidney Tubuloid Model of Repeated Cisplatin‐Induced Cellular Senescence and Fibrosis for Drug Screening

Advanced Healthcare Materials, EarlyView.
Replicating aging and senescence‐related pathophysiological responses in kidney organoids remains a significant challenge. Human adult renal tubular organoid, tubuloids, are successfully developed recapitulating cellular senescence that is the central pathophysiological mechanism of chronic kidney disease (CKD).
Yuki Nakao, Makiko Mori, Yuta Sekiguchi, Iori Morita, Ryota Shindoh, Shintaro Mandai, Tamami Fujiki, Hiroaki Kikuchi, Fumiaki Ando, Koichiro Susa, Takayasu Mori, Ayumi Suzuki, Yuji Nashimoto, Hirokazu Kaji, Yuma Waseda, Soichiro Yoshida, Yasuhisa Fujii, Eisei Sohara, Shinichi Uchida, Kensuke Miyake, Yutaro Mori   +20 more
wiley   +1 more source

Unsaturated fatty acid perturbation combats emerging triazole antifungal resistance in the human fungal pathogen Aspergillus fumigatus

mBio
Contemporary antifungal therapies utilized to treat filamentous fungal infections are inhibited by intrinsic and emerging drug resistance. Consequently, there is an urgent need to develop novel antifungal compounds that are effective against drug ...
Cecilia Gutierrez-Perez, Charles Puerner, Jane T. Jones, Sandeep Vellanki, Elisa M. Vesely, Mark A. Xatse, Andre F. C. Viera, Carissa P. Olsen, Keren O. Attiku, Steven Cardinale, Steven M. Kwasny, Narendran G-Dayanandan, Timothy J. Opperman, Robert A. Cramer   +13 more
doaj   +1 more source

UPLC-MS-ESI-QTOF Analysis and Antifungal Activity of Aqueous Extracts of Spondias tuberosa [PDF]

, 2022
Antônia Thassya Lucas dos Santos, Joara Nályda Pereira Carneiro, Rafael Pereira da Cruz, Débora Lima Sales, Jacqueline Cosmo Andrade, Maria Audilene de Freitas, Marta Regina Kerntopf, Gyllyandeson de Araújo Delmondes, Paulo Riceli Vasconcelos Ribeiro, Edy Sousa de Brito, Francisco Lucas Alves Batista, Francisco Ernani Alves Magalhães, Ivo Cavalcante Pita Neto, Maria Flaviana Bezerra Morais‐Braga, Radosław Kowalski, Grażyna Kowalska, Aleksandra Szopa, Tomasz Baj, Henrique Douglas Melo Coutinho   +18 more
openalex   +1 more source

Calli Essential Oils Synergize with Lawsone against Multidrug Resistant Pathogens. [PDF]

, 2017
The fast development of multi-drug resistant (MDR) organisms increasingly threatens global health and well-being. Plant natural products have been known for centuries as alternative medicines that can possess pharmacological characteristics, including ...
Alsaadi, Abrar I, Husseiny, Mohamed I, Ibrahim, Ashraf S, Khitrov, Gregory, Noreddin, Ayman M, Soliman, Sameh SM, Youssef, Eman G   +6 more
core   +2 more sources

Targeting Post‐Irradiation Thyroid Dysfunction: Electrospun Scaffolds As A Dual‐Action Approach for Antioxidant and Immune Modulation

Advanced Healthcare Materials, EarlyView.
Radiation‐induced hypothyroidism follows head and neck radiotherapy due to oxidative stress and inflammation. Electrospun polycaprolactone scaffolds containing adenosine have potential to modulate thyroid repair. Scaffolds enhance thyrocyte proliferation, antioxidant enzymes glutathione peroxidase and catalase, reduce senescence and apoptosis markers ...
Maria Heim, Ella‐Louise Handley, Daniel Grant, Lizi M. Hegarty, Elaine Emmerson, Anthony Callanan   +5 more
wiley   +1 more source

Differential in vitro and in vivo effect of barley cysteine and serine protease inhibitors on phytopathogenic microorganisms [PDF]

, 2011
Protease inhibitors from plants have been involved in defence mechanisms against pests and pathogens. Phytocystatins and trypsin/α-amylase inhibitors are two of the best characterized protease inhibitor families in plants.
Cambra Marin, Ines, Carrillo Gil, Laura, Diaz Rodriguez, Isabel, Herrero, Ignacio, Martinez Muñoz, Manuel, Sánchez-Monge Laguna de Rins, Rosa   +5 more
core   +2 more sources