Synthesis of Antifungal Heterocycle-Containing Mannich Bases: A Comprehensive Review
Organics, 2023 Mannich bases are a class of organic compounds usually obtained by the condensation reaction between an amine, a compound with active hydrogens, and an aldehyde.
Diego Quiroga, Ericsson Coy-Barrera
doaj +1 more source
Role of therapeutic drug monitoring in pulmonary infections : use and potential for expanded use of dried blood spot samples [PDF]
, 2015 Respiratory tract infections are among the most common infections in men. We reviewed literature to document their pharmacological treatments, and the extent to which therapeutic drug monitoring (TDM) is needed during treatment.
Akkerman, Onno W +6 more
core +2 more sources
Antifungal activity of some metabolites of higher fungi (Basidiomycetes) - an overview
Acta Societatis Botanicorum Poloniae, 2014 A series of compounds of different chemical structures showing antifungal activity were isolated from higher fungi (Basidiomycetes) fruit bodies. Among the microflora against which the examined metabolites showed effective activity, there are pathogenic ...
Teresa Florianowicz
doaj +1 more source
Quantitative Analysis of Candida Cell Wall Components by Flow Cytometrywith Triple-Fluorescence Staining [PDF]
, 2017 This work was supported by the European Commission within the FP7 Framework Programme [Fungitect-Grant No 602125]. We also thank Thomas Sauer, Vienna Biocenter Campus (VBC), Austria, for technical support at the FACS facility of the MFPL, Karl Kuchler ...
Gow, N +5 more
core +1 more source
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objective To investigate the overall use of prescription medications among individuals with multiple sclerosis compared to the general population, with a focus on treatments beyond disease‐modifying therapies. Methods We conducted a nationwide, registry‐based study in Denmark.
Josefine Windfeld‐Mathiasen +4 more
wiley +1 more source
Synthesis and antifungal activity of new O-alkylamidoximes
Bioscience Journal, 2021 The continuous prospection for molecules that may be useful in the development of new therapeutic agents is a highly relevant issue, mainly because the launch of new drugs on the market does not accompany the emergence of new resistant microorganisms. In
Maria Verônica Sales Barbosa +6 more
doaj +3 more sources
Synthesis and antifungal activity investigation of a novel clotrimazole derivative
Mongolian Journal of Chemistry, 2014 Azole antifungal agents disrupt fungal ergosterol synthesis that is essential for the formation of fungal cell membrane by preventing 14-α-demethylase enzyme from binding to its substrate.
B Zoljargal, N Davaasuren
doaj +1 more source
Antinomic natural self-protection mechanism in long-lasting woods: a case study with three tropical species from French Guiana [PDF]
, 2009 We demonstrate in this work through 3 examples that Amazonian trees may specialize longlasting woods by means of at least to different approaches. Wallaba impregnates its wood with large amounts of weakly antifungal compounds acting in synergy, while ...
Amusant, Nadine +9 more
core
Fosmanogepix (APX001) Is Effective in the Treatment of Immunocompromised Mice Infected with Invasive Pulmonary Scedosporiosis or Disseminated Fusariosis. [PDF]
, 2020 There are limited treatment options for immunosuppressed patients with lethal invasive fungal infections due to Fusarium and Scedosporium Manogepix (MGX; APX001A) is a novel antifungal that targets the conserved Gwt1 enzyme required for localization of ...
Alkhazraji, Sondus +8 more
core +1 more source
Advanced Functional Materials, EarlyView.The Angiopep‐2 peptide density on polymeric nanoparticles significantly impacts blood–brain barrier (BBB) penetration. This study explores this nuanced relationship using various in vitro models and in vivo assays, revealing that dynamic models better predict BBB penetration.
Weisen Zhang +9 more
wiley +1 more source