Results 61 to 70 of about 1,751,123 (256)

Impact of first-line antifungal agents on the outcomes and costs of candidemia [PDF]

, 2012
Candida species are the leading causes of invasive fungal infection among hospitalized patients and are responsible for major economic burdens. The goals of this study were to estimate the costs directly associated with the treatment of candidemia and ...
한상훈
core  

Programmed Interfacial Phase Separation for Spatiotemporal Fungicide Delivery via Tunable Micro/Nano Architectures

Advanced Science, EarlyView.
ABSTRACT Translating dynamic liquid‐liquid phase separation into robust solid‐state architectures remains a challenge in materials engineering. Here, we report a composition‐driven interfacial assembly strategy that couples supramolecular coacervation with metal‐phenolic coordination to engineer tunable fungicide carriers.
Rui Zhang, Tongfang Jing, Leiming He, Kaidi Cui, Yuying Song, Xuewei Mao, Lidong Cao, Lin Zhou   +7 more
wiley   +1 more source

Compare the efficacy of antifungal agents as primary therapy for invasive aspergillosis: a network meta-analysis

BMC Infectious Diseases
Background Several antifungal agents are available for primary therapy in patients with invasive aspergillosis (IA). Although a few studies have compared the effectiveness of different antifungal agents in treating IA, there has yet to be a definitive ...
Ao Liu, Liubo Xiong, Lian Wang, Han Zhuang, Xiao Gan, Mengying Zou, Xiaoming Wang   +6 more
doaj   +1 more source

Antifungal Drugs: Special Problems Treating Central Nervous System Infections

Journal of Fungi, 2019
Treating fungal infections in the central nervous system (CNS) remains a challenge despite the availability of new antifungal agents. Therapy is limited by poor understanding of the kinetic properties of antifungal drugs in the CNS compounded by lack of ...
Elizabeth Dodds Ashley
doaj   +1 more source

Antifungal Activities of SCY-078 (MK-3118) and Standard Antifungal Agents against Clinical Non-Aspergillus Mold Isolates [PDF]

, 2015
The limited armamentarium of active and oral antifungal drugs against emerging non-Aspergillus molds is of particular concern. Current antifungal agents and the new orally available beta-1,3-d-glucan synthase inhibitor SCY-078 were tested in vitro ...
Frédéric Lamoth, Alexander, B.D., Lamoth, F., Barbara D. Alexander, Alexander BD, Lamoth F   +5 more
core   +1 more source

The CXCL5/CXCR2 Axis Attenuates Ferroptosis in Intrahepatic Cholangiocarcinoma Through the Positive Feedback Loop Between PTGS2 Transcriptional Activation and Neutrophil Recruitment

Advanced Science, EarlyView.
The CXCL5/CXCR2 axis directly inhibits ferroptosis in ICC cells by activating the NF‐κB/PTGS2 pathway. Meanwhile, the CXCL5/CXCR2 axis recruits N2 TANs, and the activated PTGS2 promotes the secretion of TNF‐α from the recruited N2 TANs via the CCL2/CCL7/CCR2 pathway, thereby activating the NF‐κB/PTGS2 axis and forming a positive feedback loop, which ...
Chanqi Ye, Kefeng Lin, Shuyao Yang, Yan Zhang, Wenli Gao, Jiaqi Chen, Ying Dong, Rui Bai, Yang Tian, Minghao Wang, Zhijun Yuan, Yuxiao Ma, Yuqin He, Ruyin Chen, Wenguang Fu, Qi Jiang, Qiong Li, Jian Ruan   +17 more
wiley   +1 more source

Natural Product-Inspired Antifungal Drugs Introduced for Human Use from 1872 to August 2026

Antibiotics
This review provides a comprehensive account of 30 natural product (NP)-inspired antifungal therapeutic agents introduced for human use between 1872 and August 2026.
Mark S. Butler, Robert J. Capon
doaj   +1 more source

Genetic Differentiation, Diversity, and Drug Susceptibility of Candida krusei

Frontiers in Microbiology, 2018
Candida krusei is a notable pathogenic fungus that causes invasive candidiasis, mainly due to its natural resistance to fluconazole. However, to date, there is limited research on the genetic population features of C. krusei.
Jie Gong, Meng Xiao, Meng Xiao, He Wang, He Wang, Timothy Kudinha, Timothy Kudinha, Yu Wang, Fei Zhao, Weiwei Wu, Lihua He, Ying-Chun Xu, Ying-Chun Xu, Jianzhong Zhang   +13 more
doaj   +1 more source

Sunscreen‐Inspired Nano‐Pesticide for UV‐Shielding and Laccase‐Responsive Delivery of Mancozeb With Enhanced Fungicidal Efficacy and Ecological Safety

Advanced Science, EarlyView.
The sunscreen‐inspired nano‐pesticide, MCB@URFSL, provides UV‐shielding, enhanced rainfastness, and laccase‐responsive delivery for improved fungicidal efficacy and high ecological safety. ABSTRACT Fungicides are a crucial tool for protecting crops and ensuring consistent food supply.
Jin Yan, Xin Ye, Linping He, Cheng Hong, Xu‐Huan Zhao, Gizachew Mulugeta Manahelohe, Xiao‐Tong Feng, Yu‐Cheng Gu, Qiang Bian, Min Wu, Ming‐Zhi Zhang   +10 more
wiley   +1 more source

Antifungal pharmacodynamics: Latin America's perspective

Brazilian Journal of Infectious Diseases, 2017
The current increment of invasive fungal infections and the availability of new broad-spectrum antifungal agents has increased the use of these agents by non-expert practitioners, without an impact on mortality.
Javier M. Gonzalez, Carlos A. Rodriguez, Maria Agudelo, Andres F. Zuluaga, Omar Vesga   +4 more
doaj   +1 more source