A one‐pot protocol to synthesize reactive benzyl‐ and allyl‐halide‐substituted (dihydro)naphthalenes from 2,3‐aryl‐1,3‐butadiene substrates and halogenated alkanes has been developed, using [Cp*RuCl(PPh3)2] as the catalyst. Mechanistic studies revealed an atom transfer radical addition and radical benzannulation sequence, followed by HCl elimination ...
Nicole S. van Leeuwen +9 more
wiley +1 more source
QSPR and QSTR analysis to explore pharmacokinetic and toxicity properties of antifungal drugs through topological descriptors. [PDF]
Tamilarasi W, Balamurugan BJ.
europepmc +1 more source
Analysis of the synergistic antifungal activity of everolimus and antifungal drugs against dematiaceous fungi. [PDF]
An L +5 more
europepmc +1 more source
Versatile Palladium‐Catalyzed C‐H Arylation of Fluoroarenes with 2‐Chloropyridine Derivatives
Direct C─H arylation of fluoroarenes with 2‐chloropyridines is enabled by a simple Pd/SPhos system in isopropyl acetate. The method uses inexpensive reactants and shows broad scope and high yields. DFT computations explain reactivity and selectivity.
Federico Belnome +6 more
wiley +1 more source
<i>In vitro</i> susceptibility profiles of 16 antifungal drugs against <i>Trichophyton indotineae</i>. [PDF]
Xie W +7 more
europepmc +1 more source
Prophylaxis of Antifungal Drugs against Systemic Fungemia induced by Oral Candidiasis in Mice. [PDF]
Ninomiya K +6 more
europepmc +1 more source
Identification of Natural Isonitriles Through Ligation to an Azomethine Imine Probe
The azomethine imine (AMI)–isonitrile (NC) ligation allowed for the chemoselective detection of natural isonitriles in bacteria and fungi. The reactivity‐based screening establishes a new stereogenic center, thereby allowing for facile distinction between chiral and achiral isonitriles. The work also unraveled a unique reactivity of isonitriles bearing
Maurice P. Biedermann +6 more
wiley +1 more source
Investigation of the antifungal activity of panobinostat, tamoxifen, and miltefosine alone and in combination with some conventional antifungal drugs against fluconazole-resistant <i>Candida</i> species. [PDF]
Amirzadeh-Ghasemi F +8 more
europepmc +1 more source
Limited evidence exists synthesizing the risk of acute kidney injury (AKI) associated with the concomitant administration of multiple nephrotoxic drugs, and even less examining the concept of nephrotoxic burden. The objective of this scoping review was to (1) identify definitions of nephrotoxic burden; (2) methods used to quantify (use of calculations)
Wafa Alatawi +6 more
wiley +1 more source
Aspirin Combined with Antifungal Drugs Suppresses <i>Candida albicans</i> Biofilm by Activating Autophagy. [PDF]
Huang Y +5 more
europepmc +1 more source

