Results 91 to 100 of about 717,412 (277)

Bacterial-derived exopolysaccharides enhance antifungal drug tolerance in a cross-kingdom oral biofilm [PDF]

The ISME Journal, 2018
Abstract Fungal–bacterial interactions generate unique biofilms that cause many infections in humans. Candida albicans interact with Streptococcus mutans in dental biofilms associated with severe childhood tooth-decay, a prevalent pediatric oral disease.
Dongyeop Kim, Yuan Liu, Raphael I Benhamou, Hiram Sanchez, Áurea Simón-Soro, Yong Li, Geelsu Hwang, Micha Fridman, David R Andes, Hyun Koo   +9 more
openaire   +2 more sources

Requirement for Ergosterol in Berberine Tolerance Underlies Synergism of Fluconazole and Berberine against Fluconazole-Resistant Candida albicans Isolates

Frontiers in Cellular and Infection Microbiology, 2017
Candida albicans is one of the most common fungal pathogens. Our previous study demonstrated that concomitant use of berberine (BBR) and fluconazole (FLC) showed a synergistic action against FLC-resistant C.
Yi Xu, Hua Quan, Hua Quan, Yan Wang, Hua Zhong, Jun Sun, Jianjiang Xu, Nuan Jia, Yuanying Jiang   +8 more
doaj   +1 more source

Macrophage internalization creates a multidrug-tolerant fungal persister reservoir and facilitates the emergence of drug resistance

Nature Communications, 2023
Arastehfar et al. show that macrophage-engulfed cells of fungal pathogen Candida glabrata exhibit multidrug tolerance and increased survival in the presence of cidal antifungal drugs, forming a reservoir from which drug-resistant mutants ...
Amir Arastehfar, Farnaz Daneshnia, Nathaly Cabrera, Suyapa Penalva-Lopez, Jansy Sarathy, Matthew Zimmerman, Erika Shor, David S. Perlin   +7 more
doaj   +1 more source

Antifungal compounds in Geraldton waxflower tissues

, 2003
Geraldton waxflower is the most economically important native Australian cut flower export. Infection of waxflower by Botrytis cinerea can lead to unacceptable levels of flower abscission after harvest.
Khambay, BPS, Khambay, B. P. S., Terry, LA, Joyce, DC, Terry, L. A., Joyce, D. C.   +5 more
core   +1 more source

Symbiont‐Induced HSP83 Establishes Two‐Tiered Control of Antifungal Immunity in an Invasive Beetle–Fungus Complex

Advanced Science, EarlyView.
In an invasive beetle–fungus complex, the mutualist Leptographium procerum induces host HSP83 and modulates Toll‐dependent antifungal immunity. HSP83 mediates two‐tiered control by associating with selected fungal recognition receptors and restraining Dorsal‐driven antimicrobial peptide transcription.
Qingtai Yang, Zhudong Liu, Yuqiao Yin, Jing Su, Dunyang Yu, Longsheng Xing, Zhen Zou, Le Kang, Jianghua Sun   +8 more
wiley   +1 more source

The Neosartorya (Aspergillus) fischeri antifungal protein NFAP2 has low potential to trigger resistance development in Candida albicans in vitro

Microbiology Spectrum
Due to the increase in the number of drug-resistant Candida albicans strains, new antifungal compounds with limited potential for the development of resistance are urgently needed.
Gábor Bende, Nóra Zsindely, Krisztián Laczi, Zsolt Kristóffy, Csaba Papp, Attila Farkas, Liliána Tóth, Szabolcs Sáringer, László Bodai, Gábor Rákhely, Florentine Marx, László Galgóczy   +11 more
doaj   +1 more source

Mutant KRAS‐m6A Epitranscriptome Axis Promotes Colorectal Cancer and is a Therapeutic Target

Advanced Science, EarlyView.
Mutant KRAS‐m6A axis promotes colorectal cancer (CRC) progression. Mutant KRAS stabilizes METTL3, leading to increased m6A‐modified BCL9L mRNA and translation of BCL9L protein. BCL9L in turn mediates TGF‐β secretion to induce differentiation of Treg and an immunosuppressive microenvironment.
Danyu Chen, Pingmei Huang, Ruizhi Tao, Fenfen Ji, Qinyao Wei, Lok Hin Ko, Lianxin Zhou, Huarong Chen, Alvin Cheung, Wei Kang, Ko Fai To, Jun Yu, Chi Chun Wong   +12 more
wiley   +1 more source

Parameters affecting the reliable measurement of fluconazole tolerance using disk diffusion assays with Candida albicans

Microbiology Spectrum
Disk diffusion assays (DDAs) are widely used to determine antimicrobial susceptibility, which is measured as the size of the zone of inhibition (ZOI) after 24 h of growth, and is inversely proportional to the minimal inhibitory concentration (MIC).
Nora Kawar, Judith Berman
doaj   +1 more source

Detection of Hog1 Phosphorylation in Candida albicans in Response to an Antifungal Protein

Bio-Protocol, 2014
It is becoming increasingly apparent that stress signalling is important for tolerance of fungal species to antifungal chemicals and proteins. The high-osmolarity glycerol (HOG) pathway responds to a number of stressors including osmotic and oxidative ...
Brigitte Hayes, Nicole Weerden
doaj   +1 more source

Comparison of results of fluconazole and voriconazole disk diffusion testing for Candida spp. with results from a central reference laboratory in the ARTEMIS DISK Global Antifungal Surveillance

, 2009
The accuracy of antifungal susceptibility testing is important for reliable resistance surveillance and for the clinical management of patients with serious infections due to Candida spp.
KROEGER J, HOLLIS RJ, TENDOLKAR S, PARTICIPANT OF GLOBAL ANTIFUNGAL SURVEILLANCE GROUP, GHEZZI, Maria Cristina, MESSER SA, RAPONI, Giammarco, DIEKEMA DJ, PFALLER MA, BOYKEN L   +9 more
core   +1 more source