Results 101 to 110 of about 32,347 (265)

PEG Alternatives in Liposomal Nanocarriers: Physicochemical Characteristics and Sustainable Process Strategies

Asia-Pacific Journal of Chemical Engineering, EarlyView.
ABSTRACT The global trend toward sustainable and intensified bioprocesses is driving innovation in the design and scalable synthesis of liposomal nanocarriers, a cornerstone of modern drug delivery. For decades, these nanosystems have relied exclusively on polyethylene glycol (PEG) for their sustained circulation in vivo, but they are currently ...
Chandra Has
wiley   +1 more source

Mechanisms Of Dermatophyte Resistance To Antifungal Substances

Postępy Mikrobiologii, 2020
Dermatophytes are pathogenic fungi with high affinity for keratinised structures present in nails, skin, and hair causing superficial infections known as skin mycoses or dermatomycoses. The disease is characterised by variable prognosis.
Łagowski Dominik, Gnat Sebastian, Nowakiewicz Aneta   +2 more
doaj   +1 more source

Chlorella vulgaris biorefineries: sustainable biofuels and high‐value carbon capture

Biofuels, Bioproducts and Biorefining, EarlyView.
Abstract Global reliance on fossil fuels has created urgent economic and environmental challenges, yet large‐scale use of algal biomass remains limited by production costs. Industrial scaling is constrained by inefficient harvesting and the technical challenges of processing recalcitrant cell walls.
Sandyelle Ferreira Alcântara Araújo, Antonio Átila Menezes Ferreira, Lucia Andrea Sindeaux de Oliveira, Dayana Nascimento Dari, Devany Quintela Soares, Eliana Elisa Francelino Mavie, Francisco Leonardo Alves de Moraes Sousa, Jessica Lopes da Silva, João Vitor Gomes de Araújo Silva, Thiago Queiroz da Silva, Ana Karine Portela Vasconcelos, Kelma Maria dos Santos Pires Cavalcante, John Hebert da Silva Felix, José Cleiton Sousa dos Santos   +13 more
wiley   +1 more source

Adaptive morphological changes link to poor clinical outcomes by conferring echinocandin tolerance in Candida tropicalis.

PLoS Pathogens
Antibiotic tolerance, by which susceptible bacteria survive at high bactericide doses, is known to cause treatment failure in clinical practice. However, the impact of antifungal tolerance on clinical outcomes remains poorly understood. Here, we observed
Yongqin Wu, Yun Zou, Yuanyuan Dai, Huaiwei Lu, Wei Zhang, Wenjiao Chang, Ying Wang, Zhengchao Nie, Yuanyuan Wang, Xiaohua Jiang   +9 more
doaj   +1 more source

A Practical Gut‐On‐Chip Workflow for Imaging‐Based Assessment of Epithelial Barrier Dynamics During E. coli Co‐Culture

Biotechnology and Bioengineering, EarlyView.
ABSTRACT The intestinal epithelium and its resident microbiota form a dynamic interface that is central to gut homeostasis, but this interface is difficult to model with conventional tools. Static Transwell cultures lack physiological fluid shear, whereas animal models are costly and poorly suited to quantitative, high‐content imaging.
Shih‐Wei Chiang, Chuan‐Yi Yang, Guan‐Yu Chen   +2 more
wiley   +1 more source

Discovery of CRBN‐based molecular glue degraders targeting WIZ transcription factor

Bulletin of the Korean Chemical Society, EarlyView.
This work reports the discovery of 9l, a novel cereblon‐based molecular glue degrader which targets the WIZ transcription factor. Compound 9l facilitates WIZ‐CRBN ternary complex formation to degrade WIZ, subsequently inducing γ‐globin expression in HUDEP‐2 cells and highlighting its potential as a sickle cell disease therapy.
Tae‐Jun Kim, Seongu Seong, Jung‐Ae Kim, Taeyeon Kwon, Hyun Jin Kim, Jeong‐Hoon Kim, Jong Yeon Hwang, Jin Hwa Cho, Kyoungmin Choi   +8 more
wiley   +1 more source

CAQ Corner: Basic concepts of transplant immunology

, 2022
Liver Transplantation, EarlyView.
Amanda Cheung, Josh Levitsky
wiley   +1 more source

A GATA transcription factor contributes to multidrug resistance and pathogenicity through mediating the transcription of hydrolases and xenobiotic detoxification genes in Sclerotinia sclerotiorum

Journal of Integrative Agriculture
Phytopathogenic fungi can weaken the effectiveness of antifungal chemicals from plants and artificial synthesis through a xenobiotic detoxification system.
Kunqin Xiao, Anmo Li, Xun Xu, Yalan Li, Ling Liu, Songyang Gu, Jeffrey A. Rollins, Rui Wang, Hongyu Pan, Jinliang Liu   +9 more
doaj   +1 more source

In Vitro Anti-Biofilm Activities of Citral and Thymol Against Candida Tropicalis

Journal of Fungi, 2019
Candida tropicalis is an emerging non-albicans Candida species which is pathogenic to the immune-compromised humans, especially in tropical countries, including India.
Apurva Chatrath, Rashmi Gangwar, Poonam Kumari, Ramasare Prasad   +3 more
doaj   +1 more source

The power of many: when genetics met yeasts and high‐throughput

Biological Reviews, EarlyView.
ABSTRACT In recent years, complex technological capabilities have evolved, driven by the need to solve complex and integrative biological questions through global analyses. New equipment allows the scaling up and automation of processes which previously were carried out on a very limited scale.
Víctor A. Tallada, Víctor Carranco
wiley   +1 more source