Results 131 to 140 of about 717,412 (277)

Adaptive morphological changes link to poor clinical outcomes by conferring echinocandin tolerance in Candida tropicalis.

PLoS Pathogens
Antibiotic tolerance, by which susceptible bacteria survive at high bactericide doses, is known to cause treatment failure in clinical practice. However, the impact of antifungal tolerance on clinical outcomes remains poorly understood. Here, we observed
Yongqin Wu, Yun Zou, Yuanyuan Dai, Huaiwei Lu, Wei Zhang, Wenjiao Chang, Ying Wang, Zhengchao Nie, Yuanyuan Wang, Xiaohua Jiang   +9 more
doaj   +1 more source

Synthetic Strategies for the Construction of Cyclobutane‐Fused Heterocycles

European Journal of Organic Chemistry, EarlyView.
Cyclobutane‐fused heterocycles are important motifs commonly present in bioactive compounds, recognized for their rigid 3D structures that confer unique properties. However, synthesizing these compounds remains challenging. This review discusses current methods for their synthesis, such as photochemical, metal‐catalyzed, and Lewis acid‐mediated [2 + 2]
Michela Vargiu, Mauro Uras, Angelo Frongia   +2 more
wiley   +1 more source

Diffusion-mediated quantification of dose-dependent antifungal drug tolerance

Antimicrobial resistance is a global health problem, with drug-resistant fungi posing major challenges for the treatment of immunocompromised patients. Antifungal tolerance is a recently discovered phenomenon whereby pathogenic fungi, including the multidrug-resistant pathogenic yeast Candidozyma auris
Samira Rasouli Koohi, Clare Maristela Galon, Daniel A. Charlebois   +2 more
openaire   +1 more source

FeIII‐Mediated Synthesis of Azaspirodienones via Ipso‐Radical Cyclization of Ugi–4CR Adducts

European Journal of Organic Chemistry, EarlyView.
An efficient two‐step protocol for the synthesis of azaspirodienones via Fe‐mediated ipso‐radical cyclization of Ugi adducts has been developed. This methodology provides rapid access to these privileged spirocyclic architectures under mild conditions, offering a practical and versatile approach to generating structurally complex molecules with ...
Silvia J. Becerra–Anaya, Valeria Morales–Hernández, Luis A. Polindara–García   +2 more
wiley   +1 more source

Modular Synthesis of Di‐ and Triazadibenzoazulenes by a Cross‐Coupling/Cycloisomerization Strategy

European Journal of Organic Chemistry, EarlyView.
Two series of regioisomeric di‐ and triazadibenzoazulenes were prepared from dihalogenated imidazo[1,2‐a]pyridines and imidazo[1,2‐a]pyrazines. Imidazo[1,2‐a]pyridines and imidazo[1,2‐a]pyrazines are important nitrogen‐containing heterocycles with applications in medicinal and materials chemistry.
Karyna Kulyk, Artyom Petrosyan, Karsten Paul Lüdtke, Jonas Surkau, Martin Köckerling, Peter Ehlers, Peter Langer   +6 more
wiley   +1 more source

A GATA transcription factor contributes to multidrug resistance and pathogenicity through mediating the transcription of hydrolases and xenobiotic detoxification genes in Sclerotinia sclerotiorum

Journal of Integrative Agriculture
Phytopathogenic fungi can weaken the effectiveness of antifungal chemicals from plants and artificial synthesis through a xenobiotic detoxification system.
Kunqin Xiao, Anmo Li, Xun Xu, Yalan Li, Ling Liu, Songyang Gu, Jeffrey A. Rollins, Rui Wang, Hongyu Pan, Jinliang Liu   +9 more
doaj   +1 more source

Gold‐Catalyzed Cyclization of Indole‐Tethered Alkynes Enabling Synthesis of Exocyclic Alkenyl Tetrahydrocarbazoles

European Journal of Organic Chemistry, EarlyView.
An efficient gold‐catalyzed intramolecular cyclization of indole‐tethered alkynes using AgNTf2 as an additive has been developed, which provides bioactive exocyclic alkenyl tetrahydrocarbazoles with up to 85% yield. Control experiments and DFT studies indicate that the reaction proceeds via a 6‐exo‐dig cyclization pathway, with gold acetylide complexes
Haibo Mei, Jingrui He, Chengting Wang, Jorge Escorihuela, Jianlin Han   +4 more
wiley   +1 more source

Uncovering the connection between tunicamycin-induced respiratory deficiency and reduced fluconazole tolerance in Candida glabrata

Frontiers in Microbiology
IntroductionCandida glabrata is a prevalent opportunistic fungal pathogen in humans, and fluconazole (FLC) is one of the most commonly used antifungal agents. However, the molecular mechanisms underlying FLC tolerance in C.
Lijun Zheng, Yubo Dong, Jing Wang, Maoji Zhang, Yi Xu, Linfeng Ma, Liangsheng Guo   +6 more
doaj   +1 more source

Vaginal host–microbe signatures linked to placental outcomes in mares

Equine Veterinary Journal, EarlyView.
Abstract Background Ascending placentitis is a leading cause of late‐term pregnancy loss in mares. Although pathogens are presumed to ascend from the caudal reproductive tract, the association between the vaginal microbiome and placentitis has not been systematically examined.
Machteld van Heule, Babiche Heil, Jamie K. Norris, Kristene Gedye, Xiaoxiao Lin, Ward De Spiegelaere, Peter Daels, Pouya Dini   +7 more
wiley   +1 more source

Tolerance to the antifungal drug fluconazole is mediated by tuning cytoplasmic fluidity

Abstract Treatment failure rates for fungal infections cannot be explained simply by increased rates of drug resistance. Antifungal drug tolerance, the ability of a susceptible isolate to grow in the presence of inhibitory drug concentrations, relies upon a broad set of stress response pathways and can contribute to antifungal drug ...
Plumb, E., Serrano, A., Chevalier, Louis, Elferich, J., Sinn, L.R., Grigorieff, N., Ralser, Markus, Berman, Judith, Bassilana, M., Arkowitz, R.A.   +9 more
openaire   +1 more source