Results 211 to 220 of about 717,412 (277)

Aphid and endosymbiont sensitivity to heatwaves is misaligned across life stages

Insect Science, EarlyView.
Aphids depend on the obligate symbiont Buchnera aphidicola, which may constrain thermal tolerance. Using a factorial heatwave experiment, we exposed nymphs and adults to moderate or extreme temperatures and measured fitness and symbiont responses.
Evatt Chirgwin, Qiong Yang, Paul A. Umina, Xuan Cheng, Xinyue Gu, Alex Gill, Ary A. Hoffmann   +6 more
wiley   +1 more source

Comparative Genomics and Functional Evidence for Convergent Adaptation to Hypoxia in Mammals

Integrative Zoology, EarlyView.
This study reveals convergent selection in mammals adapted to hypoxia. Functional assays demonstrate that amino acid mutations reduce oxidative stress, attenuate hypoxia‐induced injury, and modulate the hypoxia‐inducible transcription factor (HIF)‐driven hypoxic response.
Hao Dong, Chunxu Wang, Enqing Pei, Liang Zhao, Simin Chai, Ran Tian   +5 more
wiley   +1 more source

Bioactive Constituents of <i>Piper crocatum</i> Ruiz & Pav. and <i>Piper betle</i> Linn. as Antifungal and Antibiofilm Agents Against <i>Candida albicans</i>. [PDF]

Drug Des Devel Ther
Kurnia D, Tristyaningrum NA, Herlina T, Kai K, Evangelina Iii IA.   +4 more
europepmc   +1 more source

Myeloablative Busulfan, Fludarabine and Melphalan Conditioning for Allogeneic Hematopoietic Stem Cell Transplantation in Childhood Myeloid Malignancy

Asia-Pacific Journal of Clinical Oncology, EarlyView.
We report our single‐center experience of transplant outcomes with a busulfan, fludarabine and melphalan‐based conditioning regimen for children < 18 years of age. The regimen was shown to be well tolerated and effective for heavily pretreated children with high‐risk myeloid malignancies prior to allogeneic hematopoietic stem cell transplant.
Mayank Dhamija, Fiona Kerr, Hazel Gough, Johnathan Soggee, Laurence C. Cheung, Rishi S. Kotecha, Shanti Ramachandran   +6 more
wiley   +1 more source

Pathogenesis and Triazole Resistance in <i>Aspergillus fumigatus</i>: A Narrative Review Across the Host Immune Spectrum and One Health Context. [PDF]

Infect Drug Resist
Chen T, Yao Y, Chen J, Lv H, Nan P.
europepmc   +1 more source

Efficacy and Safety of Dupilumab in Chinese Adult Patients With Chronic Rhinosinusitis With Nasal Polyps: A Randomized, Placebo‐Controlled, Phase III Trial

Allergy, EarlyView.
Dupilumab significantly improved nasal polyp score, nasal congestion, olfaction, total symptom score, and disease‐specific quality of life in Chinese patients with uncontrolled CRSwNP. Incidence of treatment‐emergent adverse events was similar between dupilumab and placebo.
Mu Xian, Menglin Wang, Changqing Zhao, Lijia Wan, Yu Xu, Juan Meng, Rui Xu, Xicheng Song, Li Shi, Yucheng Yang, Yan Jiang, Yanzhen Wu, Bethany Ling, Vivian Li, Andrew P. Fontenot, Lacey R. Robinson, Neelam A. Phadke, Chengshuo Wang, Luo Zhang   +18 more
wiley   +1 more source

Emerging Antifungal Resistance in Tropical Mycoses: A Genomic and Clinical Perspective From Endemic Zones. [PDF]

J R Soc N Z
Miraloglu M.
europepmc   +1 more source

Dendritic Cell α‐Ketoglutarate Regulates Tfh Polarization in Allergy

Allergy, EarlyView.
Allergen induces a dendritic cell metabolism shift toward glutaminolysis with α‐ketoglutarate as a regulator of Tfh subset polarization. Glutaminolysis is required for DC allergen uptake, co‐stimulatory molecule expression, and CLR expression. Modulation of glutaminolysis, JmjD3 histone demethylation, or HIF‐1α degradation alters Tfh polarization and ...
Anuj Tharakan, Xufeng Qu, Carmen Camarena, Araba Abaidoo‐Myles, Parth Naik, Jeremy Allegood, Ankit Kumar, Mihir Pokhriyal, Joseph C. Lownik, Matthew P. Zellner, Grayson W. Way, Jinze Liu, Lauren Ashley Cowart, Stephanie C. Eisenbarth, Joseph W. Landry, Daniel H. Conrad, Rebecca K. Martin   +16 more
wiley   +1 more source

Transcriptional Regulation of Azole Antifungal Resistance and Tolerance in Candida Glabrata

, 2017
openaire   +1 more source

<i>In vitro</i> exposure to the agricultural triazole tebuconazole selects for fluconazole cross-resistance and echinocandin tolerance in <i>Candidozyma auris</i>. [PDF]

Front Cell Infect Microbiol
Peng L, Xu Y, Chen X, Li W, Guo L.
europepmc   +1 more source