Results 51 to 60 of about 717,412 (277)

Dermatophyte Resistance to Antifungal Drugs: Mechanisms and Prospectus

Frontiers in Microbiology, 2018
Dermatophytes comprise pathogenic fungi that have a high affinity for the keratinized structures present in nails, skin, and hair, causing superficial infections known as dermatophytosis.
Nilce M. Martinez-Rossi, Tamires A. Bitencourt, Nalu T. A. Peres, Elza A. S. Lang, Eriston V. Gomes, Natalia R. Quaresemin, Maíra P. Martins, Lucia Lopes, Antonio Rossi   +8 more
doaj   +1 more source

Preclinical Safety, Tolerability, Pharmacokinetics, Pharmacodynamics, and Antifungal Activity of Liposomal Amphotericin B [PDF]

Clinical Infectious Diseases, 2019
The improved safety profile and antifungal efficacy of liposomal amphotericin B (LAmB) compared to conventional amphotericin B deoxycholate (DAmB) is due to several factors including, its chemical composition, rigorous manufacturing standards, and ability to target and transit through the fungal cell wall.
Adler-Moore J., Lewis R. E., Bruggemann R. J. M., Rijnders B. J. A., Groll A. H., Walsh T. J.   +5 more
openaire   +3 more sources

Loss of the Aspergillus fumigatus spindle assembly checkpoint components, SldA or SldB, generates triazole heteroresistant conidial populations

Microbiology Spectrum
The opportunistic pathogen Aspergillus fumigatus is the chief causative agent of human invasive filamentous fungal infections. Triazoles, the primary therapeutic options to combat invasive aspergillosis (IA), target the biosynthesis of ergosterol, a ...
Ashley V. Nywening, Harrison I. Thorn, Jinhong Xie, Adela Martin-Vicente, Xabier Guruceaga, Wenbo Ge, John G. Gibbons, Jarrod R. Fortwendel   +7 more
doaj   +1 more source

Table_2_Aneuploidy enables cross-tolerance to unrelated antifungal drugs in Candida parapsilosis.DOCX

, 2023
Candida parapsilosis is an emerging major human fungal pathogen. Echinocandins are first-line antifungal drugs for the treatment of invasive Candida infections.
Yong-bing Cao (10525700), Feng Yang (132135), Yuan-ying Jiang (10525697), Hao Li (31608), Liu-liu Sun (15205327), Tian-hua Yan (15205330)   +5 more
core   +1 more source

Induction of Aspergillus fumigatus zinc cluster transcription factor OdrA/Mdu2 provides combined cellular responses for oxidative stress protection and multiple antifungal drug resistance

mBio, 2023
Zinc cluster transcription factors (Zcfs) encoding zcf genes are exclusive for fungi and required for multiple cellular processes including metabolism and development.
Christoph Sasse, Emmanouil Bastakis, Fruzsina Bakti, Annalena M. Höfer, Isabella Zangl, Christoph Schüller, Anna M. Köhler, Jennifer Gerke, Sven Krappmann, Florian Finkernagel, Rebekka Harting, Joseph Strauss, Kai Heimel, Gerhard H. Braus   +13 more
doaj   +1 more source

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

Table_1_Aneuploidy enables cross-tolerance to unrelated antifungal drugs in Candida parapsilosis.DOCX

, 2023
Candida parapsilosis is an emerging major human fungal pathogen. Echinocandins are first-line antifungal drugs for the treatment of invasive Candida infections.
Yong-bing Cao (10525700), Feng Yang (132135), Yuan-ying Jiang (10525697), Hao Li (31608), Liu-liu Sun (15205327), Tian-hua Yan (15205330)   +5 more
core   +1 more source

Extracellular vesicle lipidomics liquid biopsy reveals systemic and tumor microenvironment metabolic reprogramming in ovarian cancer

Molecular Oncology, EarlyView.
Extracellular vesicle (EV) lipidomic profiling of plasma and ascites from patients with high‐grade serous ovarian cancer and of ovarian cancer cell lines reveals enrichment of triglycerides (TGs), diacylglycerols (DGs), phosphatidylcholine (PCs), sphingomyelins (SMs), reflecting tumor metabolic reprogramming.
Shikha Rani, Dominic Guanzon, Andrew Lai, Katherin Scholz‐Romero, Sarah Reed, Edita Ritmejeryte, Rohan Lourie, Naven Chetty, Kaltin Ferguson, Carlos Salomon   +9 more
wiley   +1 more source

Image_2_Aneuploidy enables cross-tolerance to unrelated antifungal drugs in Candida parapsilosis.TIF

, 2023
Candida parapsilosis is an emerging major human fungal pathogen. Echinocandins are first-line antifungal drugs for the treatment of invasive Candida infections.
Yong-bing Cao (10525700), Feng Yang (132135), Yuan-ying Jiang (10525697), Hao Li (31608), Liu-liu Sun (15205327), Tian-hua Yan (15205330)   +5 more
core   +1 more source

Evolution‐guided yeast complementation reveals functional differences in human PSPH variants

FEBS Open Bio, EarlyView.
Ancient genomes can help guide which human genetic variants are tested experimentally. This study applies that idea to PSPH, a gene involved in serine biosynthesis, and uses high‐throughput yeast complementation to compare variant function. The findings reveal measurable differences among selected alleles and illustrate the value of evolution‐guided ...
Mauricio Campa‐Álvarez, Diana Ascencio, Miguel Vallebueno‐Estrada, Eduardo González‐Orozco, Christian Eduardo Martínez‐Guerrero, Rafael Montiel, Alexander DeLuna   +6 more
wiley   +1 more source