Results 51 to 60 of about 32,347 (265)

Tolerability and safety of antifungal drugs

Reviews in Health Care, 2013
When treating critically ill patients, as those with fungal infections, attention should be focused on the appropriate use of drugs, especially in terms of dose, safety, and tolerability. The fungal infection itself and the concomitant physiological disorders concur to increase the risk of mortality in these patients, therefore the use of any ...
openaire   +3 more sources

Preclinical Safety, Tolerability, Pharmacokinetics, Pharmacodynamics, and Antifungal Activity of Liposomal Amphotericin B [PDF]

Clinical Infectious Diseases, 2019
The improved safety profile and antifungal efficacy of liposomal amphotericin B (LAmB) compared to conventional amphotericin B deoxycholate (DAmB) is due to several factors including, its chemical composition, rigorous manufacturing standards, and ability to target and transit through the fungal cell wall.
Adler-Moore J., Lewis R. E., Bruggemann R. J. M., Rijnders B. J. A., Groll A. H., Walsh T. J.   +5 more
openaire   +3 more sources

Calcineurin A of Candida albicans: involvement in antifungal tolerance, cell morphogenesis and virulence [PDF]

Molecular Microbiology, 2003
SummaryThe azole antifungal fluconazole possesses only fungistatic activity in Candida albicans and, therefore, this human pathogen is tolerant to this agent. However, tolerance to fluconazole can be inhibited when C. albicans is exposed to fluconazole combined with the immunosuppressive drug cyclosporin A, which is known to inhibit calcineurin ...
Sanglard D, Ischer F, Marchetti O, Entenza J, Bille J   +4 more
openaire   +3 more sources

Pre-Existing Liver Disease and Toxicity of Antifungals

Journal of Fungi, 2018
Pre-existing liver disease in patients with invasive fungal infections further complicates their management. Altered pharmacokinetics and tolerance issues of antifungal drugs are important concerns.
Nikolaos Spernovasilis, Diamantis P. Kofteridis   +1 more
doaj   +1 more source

Overexpression of Yeast YLR177w gene provides tolerance to antifungal drug Tioconazole

Annals of Medical Research, 2022
Aim: To find genes that provide resistance to antifungal drug tioconazole by a genomic screening approach. Materials and Methods: Wild-type yeast (BY4741) cells were transformed with a high copy genomic DNA expression library and transformants that can grow on toxic levels of Tioconazole were determined.
Salman Ko, zlem k, Muhammed ndar, AHMET KO   +3 more
openaire   +1 more source

Targeting Post‐Irradiation Thyroid Dysfunction: Electrospun Scaffolds As A Dual‐Action Approach for Antioxidant and Immune Modulation

Advanced Healthcare Materials, EarlyView.
Radiation‐induced hypothyroidism follows head and neck radiotherapy due to oxidative stress and inflammation. Electrospun polycaprolactone scaffolds containing adenosine have potential to modulate thyroid repair. Scaffolds enhance thyrocyte proliferation, antioxidant enzymes glutathione peroxidase and catalase, reduce senescence and apoptosis markers ...
Maria Heim, Ella‐Louise Handley, Daniel Grant, Lizi M. Hegarty, Elaine Emmerson, Anthony Callanan   +5 more
wiley   +1 more source

Loss of the Aspergillus fumigatus spindle assembly checkpoint components, SldA or SldB, generates triazole heteroresistant conidial populations

Microbiology Spectrum
The opportunistic pathogen Aspergillus fumigatus is the chief causative agent of human invasive filamentous fungal infections. Triazoles, the primary therapeutic options to combat invasive aspergillosis (IA), target the biosynthesis of ergosterol, a ...
Ashley V. Nywening, Harrison I. Thorn, Jinhong Xie, Adela Martin-Vicente, Xabier Guruceaga, Wenbo Ge, John G. Gibbons, Jarrod R. Fortwendel   +7 more
doaj   +1 more source

Resistance to the Plant Defensin NaD1 Features Modifications to the Cell Wall and Osmo-Regulation Pathways of Yeast

Frontiers in Microbiology, 2018
Over the last few decades, the emergence of resistance to commonly used antifungal molecules has become a major barrier to effective treatment of recurrent life-threatening fungal diseases.
Amanda I. McColl, Mark R. Bleackley, Marilyn A. Anderson, Rohan G. T. Lowe   +3 more
doaj   +1 more source

Small, Cationic Antifungal Proteins from Filamentous Fungi Inhibit Candida albicans Growth in 3D Skin Infection Models

Microbiology Spectrum, 2022
The emerging resistance of human-pathogenic fungi to antifungal drugs urges the development of alternative therapeutic strategies. The small, cationic antifungal proteins (AFPs) from filamentous ascomycetes represent promising candidates for next ...
Jeanett Holzknecht, Sandrine Dubrac, Sarah Hedtrich, László Galgóczy, Florentine Marx   +4 more
doaj   +1 more source

Tolerance of Trichoderma sp. to Heavy Metals and its Antifungal Activity in Algerian Marine Environment

, 2018
Western Algerian waste line is a dump of any form of pollution. Therefore sampling sites are ports, also close to urban waste which shelter a wide variety of fungal population.
Farah Ayad, Mohamed Bouderbala, Omar Rouane–Hacene, Amaria Matallah-Boutiba, Zitouni Boutiba   +4 more
core   +1 more source