Results 61 to 70 of about 717,412 (277)
Saccharomyces cerevisiae biofilm tolerance towards systemic antifungals depends on growth phase [PDF]
BMC Microbiology, 2014 Biofilm-forming Candida species cause infections that can be difficult to eradicate, possibly because of antifungal drug tolerance mechanisms specific to biofilms. In spite of decades of research, the connection between biofilm and drug tolerance is not fully understood.We used Saccharomyces cerevisiae as a model for drug susceptibility of yeast ...
Bojsen, Rasmus +2 more
openaire +5 more sources
Overexpression of Yeast YLR177w gene provides tolerance to antifungal drug Tioconazole
Annals of Medical Research, 2022 Aim: To find genes that provide resistance to antifungal drug tioconazole by a genomic screening approach. Materials and Methods: Wild-type yeast (BY4741) cells were transformed with a high copy genomic DNA expression library and transformants that can grow on toxic levels of Tioconazole were determined.
Salman Ko +3 more
openaire +1 more source
Applications of single-cell RNA sequencing in fungal infections
Frontiers in MicrobiologyFungal infection elicits markedly different cellular responses depending on the pathogen, tissue involved, host immune status, and stage of disease.
Xi Shen, Guanzhi Chen, Lingyue Sun
doaj +1 more source
, 2023 Candida parapsilosis is an emerging major human fungal pathogen. Echinocandins are first-line antifungal drugs for the treatment of invasive Candida infections.
Yong-bing Cao (10525700) +5 more
core +1 more source
FEBS Open Bio, EarlyView.The presence of biotin‐binding avidin proteins in fish and their biological significance are poorly characterized. We cataloged fish avidins and demonstrate that they are widely present and evolutionarily conserved. We created avd knockout zebrafish and show that zebavidin is dispensable for development and that resistance of avd knockout embryos in ...
Anni K. Saralahti +5 more
wiley +1 more source
, 2023 Candida parapsilosis is an emerging major human fungal pathogen. Echinocandins are first-line antifungal drugs for the treatment of invasive Candida infections.
Yong-bing Cao (10525700) +5 more
core +1 more source
Advanced Functional Materials, EarlyView.This study advances SafeWax, a bio‐inspired, fatty‐acids‐based superhydrophobic coating, by identifying an agriculturally compliant solvent and revealing how solvent‐controlled Fatty acid crystallization governs the coating's microscopic structure and performance.
Niv Ben‐Arie +13 more
wiley +1 more source
Trafficking through the Late Endosome Significantly Impacts Candida albicans Tolerance of the Azole Antifungals [PDF]
Antimicrobial Agents and Chemotherapy, 2015 ABSTRACT The azole antifungals block ergosterol biosynthesis by inhibiting lanosterol demethylase (Erg11p). The resulting depletion of cellular ergosterol and the accumulation of “toxic” sterol intermediates are both thought to compromise plasma membrane function.
Luna Tapia, Arturo +4 more
openaire +3 more sources
mBioCryptococcus neoformans (Cn) is an opportunistic fungal microorganism that causes life-threatening meningoencephalitis. During the infection, the microbial population is heterogeneously composed of cells with varying generational ages, with older cells ...
Kyungyoon Yoo +6 more
doaj +1 more source
Pre-Existing Liver Disease and Toxicity of Antifungals
Journal of Fungi, 2018 Pre-existing liver disease in patients with invasive fungal infections further complicates their management. Altered pharmacokinetics and tolerance issues of antifungal drugs are important concerns.
Nikolaos Spernovasilis +1 more
doaj +1 more source