Results 1 to 10 of about 1,150,155 (343)

A comprehensive antigen-antibody complex database unlocking insights into interaction interface [PDF]

eLife
Antibodies are critical components of the vertebrate immune system and possess a wide array of biomedical applications. Elucidating the complex interactions between antibodies and antigens is an important step in drug development.
Yuwei Zhou, Wenwen Liu, Ziru Huang, Yushu Gou, Siqi Liu, Lixu Jiang, Yue Yang, Jian Huang   +7 more
doaj   +2 more sources

Design of Antibody-Functionalized Polymeric Membranes for the Immunoisolation of Pancreatic Islets [PDF]

Applied Sciences, 2020
An immunoencapsulation strategy for pancreatic islets aimed to reduce the risk of rejection in transplanted patients due to the immune response of the host organism is proposed.
Anna Cavallo, Ugo Masullo, Alessandra Quarta, Alessandro Sannino, Amilcare Barca, Tiziano Verri, Marta Madaghiele, Laura Blasi   +7 more
doaj   +3 more sources

Antigen–antibody complex density and antibody-induced HLA protein unfolding influence Fc-mediated antibody effector function [PDF]

Frontiers in Immunology
Donor-specific antibodies (DSAs) targeting mismatched human leukocyte antigen (HLA) molecules are one of the principal threats to long-term graft survival in solid organ transplantation.
Tanusya Murali Murali, Tanusya Murali Murali, Tanusya Murali Murali, Yue Gu, Yue Gu, Rabiatul Adawiyah Minhat, Jiawei Yap, Jiawei Yap, Kathryn J. Wood, Cheng-I Wang, Nicholas R. J. Gascoigne, Nicholas R. J. Gascoigne, Vathsala Anantharaman, Vathsala Anantharaman, Paul Anthony MacAry, Paul Anthony MacAry, Paul Anthony MacAry   +16 more
doaj   +2 more sources

Immune-complex mimics as a molecular platform for adjuvant-free vaccine delivery. [PDF]

PLoS ONE, 2013
Protein-based vaccine development faces the difficult challenge of finding robust yet non-toxic adjuvants suitable for humans. Here, using a molecular engineering approach, we have developed a molecular platform for generating self-adjuvanting immunogens
Ilaria Pepponi, Elena Stylianou, Craig van Dolleweerd, Gil Reynolds Diogo, Matthew J Paul, Pascal M W Drake, Julian K-C Ma, Rajko Reljic   +7 more
doaj   +4 more sources

Development of egg yolk-based polyclonal antibodies and immunoprophylactic potential of antigen-antibody complex against infectious bursal disease [PDF]

Veterinary and Animal Science
A study conducted in the Faisalabad district sampled 50 cases across five IBD outbreaks, revealing an alarming 80 % infection rate among poultry.
Sanaullah Sajid, Sajjad ur Rahman, Mashkoor Mohin, Zia ud Din Sindhu   +3 more
doaj   +2 more sources

STUDIES ON ANTIGEN-ANTIBODY COMPLEXES [PDF]

, 1971
Solid phase immunoadsorbents were prepared by coupling antigens to agarose. With this technique specific antibodies were easily isolated in large amounts.
Mart Mannik, William P. Arend, Anthony P. Hall, Bruce C. Gilliland   +3 more
openalex   +2 more sources

THE UNLABELED ANTIBODY ENZYME METHOD OF IMMUNOHISTOCHEMISTRY PREPARATION AND PROPERTIES OF SOLUBLE ANTIGEN-ANTIBODY COMPLEX (HORSERADISH PEROXIDASE-ANTIHORSERADISH PEROXIDASE) AND ITS USE IN IDENTIFICATION OF SPIROCHETES [PDF]

Journal of Histochemistry and Cytochemistry, 1970
Ludwig A. Sternberger, Paul H. Hardy, John J. Cuculis, Howard G. Meyer   +3 more
openalex   +2 more sources

Correlation of N-glycan dynamics and interaction network with allosteric antigen binding and Fc receptor recognition

Exploration of Immunology, 2021
Aim: Fragment crystallizable (Fc) glycans modulate Fc conformations and functions, and glycan may also regulate antigen recognition. In the antibody drug development, glycosylation patterns affect antibody drug characteristics and quality control.
Buyong Ma
doaj   +1 more source

Elimination of plasma soluble antigen in cynomolgus monkeys by combining pH-dependent antigen binding and novel Fc engineering

mAbs, 2022
A conventional antibody targeting a soluble antigen in circulation typically requires a huge dosage and frequent intravenous administration to neutralize the antigen.
Yuji Hori, Ken Ohmine, Hitoshi Katada, Yuki Noguchi, Kazuki Sato, Takeru Nambu, Lam Runyi Adeline, Gan Siok Wan, Kenta Haraya, Kazuhisa Ozeki, Masahiko Nanami, Tatsuhiko Tachibana, Zenjiro Sampei, Taichi Kuramochi, Junichi Nezu, Kunihiro Hattori, Tomoyuki Igawa   +16 more
doaj   +1 more source

Learned features of antibody-antigen binding affinity

Frontiers in Molecular Biosciences, 2023
Defining predictors of antigen-binding affinity of antibodies is valuable for engineering therapeutic antibodies with high binding affinity to their targets.
Nathaniel L. Miller, Nathaniel L. Miller, Thomas Clark, Thomas Clark, Rahul Raman, Rahul Raman, Ram Sasisekharan, Ram Sasisekharan   +7 more
doaj   +1 more source