Results 1 to 10 of about 1,778,950 (367)

A comprehensive antigen-antibody complex database unlocking insights into interaction interface [PDF]

eLife
Antibodies are critical components of the vertebrate immune system and possess a wide array of biomedical applications. Elucidating the complex interactions between antibodies and antigens is an important step in drug development.
Yuwei Zhou, Wenwen Liu, Ziru Huang, Yushu Gou, Siqi Liu, Lixu Jiang, Yue Yang, Jian Huang   +7 more
doaj   +4 more sources

AbAgym: a well-curated dataset for the mutational analysis of antibody–antigen complexes [PDF]

mAbs
With monoclonal antibodies becoming one of the largest classes of biopharmaceuticals, it is important to have curated data to train computational models that can accelerate their design.
Gabriel Cia, Dong Li, Simón Poblete, Marianne Rooman, Fabrizio Pucci   +4 more
doaj   +4 more sources

Antigen–antibody complex density and antibody-induced HLA protein unfolding influence Fc-mediated antibody effector function [PDF]

Frontiers in Immunology
Donor-specific antibodies (DSAs) targeting mismatched human leukocyte antigen (HLA) molecules are one of the principal threats to long-term graft survival in solid organ transplantation.
Tanusya Murali Murali, Tanusya Murali Murali, Tanusya Murali Murali, Yue Gu, Yue Gu, Rabiatul Adawiyah Minhat, Jiawei Yap, Jiawei Yap, Kathryn J. Wood, Cheng-I Wang, Nicholas R. J. Gascoigne, Nicholas R. J. Gascoigne, Vathsala Anantharaman, Vathsala Anantharaman, Paul Anthony MacAry, Paul Anthony MacAry, Paul Anthony MacAry   +16 more
doaj   +2 more sources

Development of egg yolk-based polyclonal antibodies and immunoprophylactic potential of antigen-antibody complex against infectious bursal disease [PDF]

Veterinary and Animal Science
A study conducted in the Faisalabad district sampled 50 cases across five IBD outbreaks, revealing an alarming 80 % infection rate among poultry.
Sanaullah Sajid, Sajjad ur Rahman, Mashkoor Mohin, Zia ud Din Sindhu   +3 more
doaj   +2 more sources

De novo design of epitope-specific antibodies via a structure-driven computational workflow [PDF]

Nature Communications
Accurate modeling of antibody-antigen complex structures holds significant potential for advancing biomedical research and the design of therapeutic antibodies.
Fandi Wu, Yu Zhao, JiaXiang Wu, Biaobin Jiang, Bing He, Longkai Huang, Chenchen Qin, Yang Xiao, Fan Yang, Rubo Wang, Ningqiao Huang, Huaxian Jia, Yuyi Liu, Houtim Lai, Tingyang Xu, Fang Wang, Zihan Wu, Yidong Song, Shaoning Li, Wei Liu, Yu Rong, Peilin Zhao, Jianhua Yao   +22 more
doaj   +2 more sources

AFM study of complement system assembly initiated by antigen-antibody complex [PDF]

, 2006
The shape and size of complement system C1 components assembled on a SiO2 surface after classical activation by antigen-antibody complex was determined by tapping mode atomic force microscopy (AFM).
A. Ramanavičienė, V. Snitka, Rasa Mieliauskiene, R. Kazlauskas, A. Ramanavičius   +4 more
semanticscholar   +2 more sources

Three-dimensional structure of a heteroclitic antigen-antibody cross-reaction complex. [PDF]

Proceedings of the National Academy of Sciences of the United States of America, 1993
V. Chitarra, P. Alzari, Graham A. Bentley, T. N. Bhat, Jean-Luc Eiselé, A. Houdusse, Julien Lescar, H. Souchon, Roberto J. Poljak   +8 more
semanticscholar   +2 more sources

Correlation of N-glycan dynamics and interaction network with allosteric antigen binding and Fc receptor recognition

Exploration of Immunology, 2021
Aim: Fragment crystallizable (Fc) glycans modulate Fc conformations and functions, and glycan may also regulate antigen recognition. In the antibody drug development, glycosylation patterns affect antibody drug characteristics and quality control.
Buyong Ma
doaj   +1 more source

Elimination of plasma soluble antigen in cynomolgus monkeys by combining pH-dependent antigen binding and novel Fc engineering

mAbs, 2022
A conventional antibody targeting a soluble antigen in circulation typically requires a huge dosage and frequent intravenous administration to neutralize the antigen.
Yuji Hori, Ken Ohmine, Hitoshi Katada, Yuki Noguchi, Kazuki Sato, Takeru Nambu, Lam Runyi Adeline, Gan Siok Wan, Kenta Haraya, Kazuhisa Ozeki, Masahiko Nanami, Tatsuhiko Tachibana, Zenjiro Sampei, Taichi Kuramochi, Junichi Nezu, Kunihiro Hattori, Tomoyuki Igawa   +16 more
doaj   +1 more source

STUDIES ON ANTIGEN-ANTIBODY COMPLEXES [PDF]

The Journal of Experimental Medicine, 1971
The Journal of Experimental Medicine, Vol. 133, No. 4, April 1, 1971, page 719, line 1: For 357,000 read 313,000.
Mart Mannik, William P. Arend, Anthony P. Hall, Bruce C. Gilliland   +3 more
openaire   +3 more sources