Results 41 to 50 of about 1,150,155 (343)

The structures of secretory and dimeric immunoglobulin A [PDF]

, 2020
Secretory (S) Immunoglobulin (Ig) A is the predominant mucosal antibody, which binds pathogens and commensal microbes. SIgA is a polymeric antibody, typically containing two copies of IgA that assemble with one joining-chain (JC) to form dimeric (d) IgA ...
Haloi, Nandan, Huey-Tubman, Kathryn E., Kumar Bharathkar, Sonya, Malyutin, Andrey G., Parker, Benjamin W., Stadtmueller, Beth M., Tajkhorshid, Emad   +6 more
core  

Complementing antibody profiles: Assessing antibody function on antigen microarrays [PDF]

, 2012
Antibody effector functions other than neutralization depend on interactions with soluble and cellular components of the immune system. Antigen recognition is usually oligoclonal, with the different clones of antibodies belonging to different ...
Papp, Krisztián, Prechl, József, Szittner, Zoltán   +2 more
core   +1 more source

AFM study of complement system assembly initiated by antigen-antibody complex

, 2006
The shape and size of complement system C1 components assembled on a SiO2 surface after classical activation by antigen-antibody complex was determined by tapping mode atomic force microscopy (AFM).
A. Ramanavičienė, V. Snitka, Rasa Mieliauskiene, R. Kazlauskas, A. Ramanavičius   +4 more
semanticscholar   +1 more source

Contribution of Asparagine Residues to the Stabilization of a Proteinaceous Antigen-Antibody Complex, HyHEL-10-Hen Egg White Lysozyme*

Journal of Biological Chemistry, 2009
Many germ line antibodies have asparagine residues at specific sites to achieve specific antigen recognition. To study the role of asparagine residues in the stabilization of antigen-antibody complexes, we examined the interaction between hen egg white ...
A. Yokota, K. Tsumoto, M. Shiroishi, T. Nakanishi, H. Kondo, I. Kumagai   +5 more
semanticscholar   +1 more source

Structural Features of Antibody-Peptide Recognition

Frontiers in Immunology, 2022
Antibody recognition of antigens is a critical element of adaptive immunity. One key class of antibody-antigen complexes is comprised of antibodies targeting linear epitopes of proteins, which in some cases are conserved elements of viruses and pathogens
Jessica H. Lee, Rui Yin, Rui Yin, Gilad Ofek, Gilad Ofek, Brian G. Pierce, Brian G. Pierce, Brian G. Pierce   +7 more
doaj   +1 more source

Structural Consequences of Mutations in Interfacial Tyr Residues of a Protein Antigen-Antibody Complex

Journal of Biological Chemistry, 2007
Tyrosine is an important amino acid in protein-protein interaction hot spots. In particular, many Tyr residues are located in the antigen-binding sites of antibodies and endow high affinity and high specificity to these antibodies.
M. Shiroishi, K. Tsumoto, Yoshikazu Tanaka, A. Yokota, T. Nakanishi, H. Kondo, I. Kumagai   +6 more
semanticscholar   +1 more source

Polyclonal antibody responses to HIV Env immunogens resolved using cryoEM

Nature Communications, 2021
Here, the authors present cryoEMPEM, a method for high-resolution structural analysis of vaccine-elicited polyclonal antibody responses. They apply cryoEMPEM in combination with standard serology experiments to characterize the polyclonal antibody (pAb ...
Aleksandar Antanasijevic, Leigh M. Sewall, Christopher A. Cottrell, Diane G. Carnathan, Luis E. Jimenez, Julia T. Ngo, Jennifer B. Silverman, Bettina Groschel, Erik Georgeson, Jinal Bhiman, Raiza Bastidas, Celia LaBranche, Joel D. Allen, Jeffrey Copps, Hailee R. Perrett, Kimmo Rantalainen, Fabien Cannac, Yuhe R. Yang, Alba Torrents de la Peña, Rebeca Froes Rocha, Zachary T. Berndsen, David Baker, Neil P. King, Rogier W. Sanders, John P. Moore, Shane Crotty, Max Crispin, David C. Montefiori, Dennis R. Burton, William R. Schief, Guido Silvestri, Andrew B. Ward   +31 more
doaj   +1 more source

Complete analysis of the B-cell response to a protein antigen, from in vivo germinal centre formation to 3-D modelling of affinity maturation [PDF]

, 2003
Somatic hypermutation of immunoglobulin variable region genes occurs within germinal centres (GCs) and is the process responsible for affinity maturation of antibodies during an immune response.
Batista FD, Berek C, Berek C., Betz AG, Bonhomme D, Chothia C, England P, Griffiths GM, Guermonprez P, Jacob J, Jacob J, Kosco-Vilbois MH, Lanzavecchia A., Lavoie TB, Lavoie TB, Liu A, Liu Y-J, Max EE, Morsky P., Murphy KM, Neuberger MS, Newman MA, Novick HE, Padlan EA, Peters A, Roost HP, Sharon J., Sims GP, Smith KM, Smith-Gill SJ, Smith-Gill SJ, Smith-Gill SJ, Smith-Gill SJ, Storb U, Tze LE, Vora KA, Ziegner M   +36 more
core   +3 more sources

Structure of CD20 in complex with the therapeutic monoclonal antibody rituximab

Science, 2020
Clustering for the kill Cluster of differentiation 20 (CD20) is a membrane protein that defines most B cell populations and is the target of therapeutic antibodies to treat malignancies and autoimmune disorders. Rougé et al. present the structure of CD20
L. Rougé, Nancy Chiang, M. Steffek, Christine Kugel, T. Croll, C. Tam, A. Estevez, C. Arthur, C. Koth, C. Ciferri, E. Kraft, J. Payandeh, G. Nakamura, J. T. Koerber, A. Rohou   +14 more
semanticscholar   +1 more source

SnugDock: paratope structural optimization during antibody-antigen docking compensates for errors in antibody homology models.

PLoS Computational Biology, 2010
High resolution structures of antibody-antigen complexes are useful for analyzing the binding interface and to make rational choices for antibody engineering.
Aroop Sircar, Jeffrey J Gray
doaj   +1 more source