Results 71 to 80 of about 1,778,950 (367)

Analysis of CD83 antigen expression in human breast fibroadenoma and adjacent tissue

São Paulo Medical Journal
CONTEXT AND OBJECTIVE: Dendritic cell maturation is considered essential for starting an immune response. The CD83 antigen is an important marker of dendritic cell maturation.
Marcus Nascimento Borges, Gil Facina, Ismael Dale Cotrin Guerreiro Silva, Angela Flávia Logullo Waitzberg, Afonso Celso Pinto Nazario   +4 more
doaj   +1 more source

THE "DELAYED HYPERSENSITIVITY" INDUCED BY ANTIGEN-ANTIBODY COMPLEXES [PDF]

The Journal of Experimental Medicine, 1958
The "delayed hypersensitive" reactivity induced by antigen-antibody complexes has been studied from the standpoints of the role of such complexes in establishing this state, and the relationship of this state to classical delayed hypersensitivity. It has been shown that the reactivity established by antigen-antibody complexes appears ...
S, RAFFEL, J M, NEWEL
openaire   +2 more sources

Epstein-Barr virus nuclear antigen 3A protein regulates CDKN2B transcription via interaction with MIZ-1 [PDF]

, 2014
The Epstein-Barr virus (EBV) nuclear antigen 3 family of protein is critical for the EBV-induced primary B-cell growth transformation process. Using a yeast two-hybrid screen we identified 22 novel cellular partners of the EBNA3s. Most importantly, among
Bazot, Q, Deschamps, T, Gruffat, H, Harth-Hertle, ML, Kempkes, B, Leblanc, P, Lotteau, V, Manet, E, Rabourdin-Combe, C, Siouda, M, Tafforeau, L, Tommasino, M   +11 more
core   +6 more sources

Patient‐specific pharmacogenomics demonstrates xCT as predictive therapeutic target in colon cancer with possible implications in tumor connectivity

Molecular Oncology, EarlyView.
This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker, Keren Zohar, Martin Böttcher, Thomas Wartmann, Henry Freudenstein, Maximilian Doelling, Mihailo Andric, Wenjie Shi, Or Kakhlon, Katrin Hippe, Beatrix Jahnke, Dimitrios Mougiakakos, Franziska Baenke, Daniel Stange, Roland S. Croner, Michal Linial, Ulf D. Kahlert   +16 more
wiley   +1 more source

An antibody raised against a pathogenic serpin variant induces mutant-like behaviour in the wild-type protein. [PDF]

, 2015
A monoclonal antibody (mAb) that binds to a transient intermediate may act as a catalyst for the corresponding reaction; here we show this principle can extend on a macro-molecular scale to the induction of mutant-like oligomerisation in a wild-type ...
Faull, SV, Haq, I, Irving, JA, Kotov, VR, Lomas, DA, Miranda, E, Motamedi-Shad, N, Perez, J   +7 more
core   +1 more source

Aggressive prostate cancer is associated with pericyte dysfunction

Molecular Oncology, EarlyView.
Tumor‐produced TGF‐β drives pericyte dysfunction in prostate cancer. This dysfunction is characterized by downregulation of some canonical pericyte markers (i.e., DES, CSPG4, and ACTA2) while maintaining the expression of others (i.e., PDGFRB, NOTCH3, and RGS5).
Anabel Martinez‐Romero, Ane Martinez‐Larrinaga, Joaquim Grego‐Bessa, Saioa Garcia‐Longarte, Hielke van Splunder, Ianire Astobiza, Amaia Ercilla, Laura Bozal‐Basterra, Isabel Mendizabal, Pilar Villacampa, Arkaitz Carracedo, Mariona Graupera   +11 more
wiley   +1 more source

Structural insights into chemokine CCL17 recognition by antibody M116

Biochemistry and Biophysics Reports, 2018
The homeostatic chemokine CCL17, also known as thymus and activation regulated chemokine (TARC), has been associated with various diseases such as asthma, idiopathic pulmonary fibrosis, atopic dermatitis and ulcerative colitis. Neutralization of CCL17 by
Alexey Teplyakov, Galina Obmolova, Gary L. Gilliland   +2 more
doaj   +1 more source

Increasing temperature denatures canine IgG reducing its ability to inhibit heartworm antigen detection

Parasites & Vectors, 2023
Background Immune complexing of target antigen to high affinity host antibody is recognized to impact the sensitivity of commercial heartworm antigen tests.
Jeff M. Gruntmeir, Jeff R. Abbott, Peter E. Kima, Maureen T. Long, Byron L. Blagburn, Heather S. Walden   +5 more
doaj   +1 more source

Complementing antibody profiles: Assessing antibody function on antigen microarrays [PDF]

, 2012
Antibody effector functions other than neutralization depend on interactions with soluble and cellular components of the immune system. Antigen recognition is usually oligoclonal, with the different clones of antibodies belonging to different ...
Papp, Krisztián, Prechl, József, Szittner, Zoltán   +2 more
core   +1 more source

Glycosylated LGALS3BP is highly secreted by bladder cancer cells and represents a novel urinary disease biomarker

Molecular Oncology, EarlyView.
Urinary LGALS3BP is elevated in bladder cancer patients compared to healthy controls as detected by the 1959 antibody–based ELISA. The antibody shows enhanced reactivity to the high‐mannose glycosylated variant secreted by cancer cells treated with kifunensine (KIF).
Asia Pece, Giulio Lovato, Ilaria Cela, Arianna Mercatelli, Benedetta Ferro, Jussi Nikkola, Sara Pagotto, Tommaso Grottola, Vincenzo De Laurenzi, Rossella Cicchetti, Antonio Marchetti, Luigi Schips, Rossano Lattanzio, Stefano Iacobelli, Emily Capone, Peter Black, Mads Daugaard, Michele Marchioni, Gianluca Sala   +18 more
wiley   +1 more source