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Antigen presentation, antigen-presenting cells and antigen processing
Current Opinion in Immunology, 1988To summarize, during the period under review there have been considerable advances in our understanding of how antigen is associated with MHC on the surface of a presenting cell. Basic rules which govern this association have been confirmed as including both the nature and the configuration of the antigen.
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T cells as antigen-presenting cells
Immunology Today, 1994Human T cells express major histocompatibility complex (MHC) class II antigens and adhesion molecules characteristic of antigen-presenting cells (APCs), and recent in vitro and in vivo evidence supports an antigen-presenting function for T cells. In this guise, T cells provide downregulatory signals for the immune response by inducing anergy in T cells
W J, Pichler, T, Wyss-Coray
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1985
Three major issues were discussed in the workshop: (1) the role of antigen processing in T-cell activation and situations in which it may not be necessary for T-cell stimulation, (2) the differences in antigen presenting function of macrophages and dendritic cells and the ability of dendritic cells to process antigen, and (3) the role of the type of ...
Jay A. Berzofsky, Kozo Yokomuro
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Three major issues were discussed in the workshop: (1) the role of antigen processing in T-cell activation and situations in which it may not be necessary for T-cell stimulation, (2) the differences in antigen presenting function of macrophages and dendritic cells and the ability of dendritic cells to process antigen, and (3) the role of the type of ...
Jay A. Berzofsky, Kozo Yokomuro
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Antigen Presentation to B Cells
Trends in Immunology, 2016Unlike T cells that recognize digested peptides, B cells recognize their cognate antigen in its native form. The B cell receptor used in recognition can also be secreted to bind to antigens and initiate multiple effector functions such as phagocytosis, complement activation, or neutralization of receptors.
Balthasar A, Heesters +3 more
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Cell biology of antigen presentation
Current Opinion in Immunology, 1993MHC class I molecules present degradation products derived from intracellular proteins, whereas MHC class II molecules generally present peptides derived from extracellular or surface proteins. Recent insights into the cell biology of MHC class I and II molecules explain this difference.
J J, Neefjes, F, Momburg
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Basophils as antigen presenting cells
Trends in Immunology, 2010Recent reports demonstrate that basophils act as antigen presenting cells to drive Th2 and IgE responses against protease and protein allergens and helminth parasites. Through MHC class II-dependent cognate interactions with CD4(+) T cells in the context of co-stimulatory molecules, and through secretion of IL-4, IL-13 and thymic stromal lymphopoietin,
Maddur, Mohan +2 more
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Antigen-presenting cells in allergy
Journal of Allergy and Clinical Immunology, 2001The complex interaction of the innate and adaptive immune system requires flexibility and cooperation among various cell types. In this regard, antigen-presenting-cells (APCs) play a pivotal role in transferring information from the periphery of the organism to lymphoid organs, where they initiate the activation of naive T cells.
D, von Bubnoff, E, Geiger, T, Bieber
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B cells as antigen presenting cells
Cellular Immunology, 2005Several characteristics confer on B cells the ability to present antigen efficiently: (1) they can find T cells in secondary lymphoid organs shortly after antigen entrance, (2) BCR-mediated endocytosis allows them to concentrate small amounts of specific antigen, and (3) BCR signaling and HLA-DO expression direct their antigen processing machinery to ...
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Antigen presentation to B cells
Current Opinion in Immunology, 1991B lymphocytes encounter antigen within the body, which causes them to undergo clonal expansion, affinity maturation and differentiation to antibody-forming cells. How they come into contact with the immunogen, and the subsequent response induced is the subject of several recent reports.
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