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Antigen-presenting cells for unprimed T cells
Immunology Today, 1989The triggering requirements of T cells differ for primed and unprimed cells: primed T cells can be triggered to produce lymphokines without viable antigen-presenting cells (APCs), apparently by crosslinking the T-cell receptor (TCR). Unprimed T cells do, however, require viable APCs and here Jonathan Sprent and Mary Schaefer review what type of cells ...
Jonathan Sprent, M Schaefer
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Corneal Antigen-Presenting Cells
2007Corneal antigen-presenting cells (APCs) were thought to reside exclusively in the peripheral cornea. However, recent evidence demonstrates that the central cornea is also endowed with a heterogeneous population of bone marrow-derived cells, including epithelial Langerhans cells (LCs) and anterior stromal dendritic cells (DCs), which under certain ...
Pedram Hamrah, Reza Dana
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Epithelial cell antigen presentation
Current Opinion in Gastroenterology, 2000For decades intestinal epithelial cells were thought of as passive barriers to luminal contents, cells involved in nutrient absorption and electrolyte secretion. Studies during the past 10 to 15 years have changed that concept as our understanding of mucosal immunity has evolved and as we have come to understand that the regulation of this system is ...
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Antigen-Presenting Cells in the Decidua
2005Maternal tolerance against fetal antigens is still one of the unsolved questions in pregnancy. Focusing on the various subsets of immune cells playing in concert with the human immune system, tolerance induction is nowadays often accredited to a specialized group of immune cells, the antigen-presenting cells (APC).
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Antigen Presentation by Human Antigen‐Presenting Cells to Antigen‐Specific Xenogeneic Murine T Cells
Microbiology and Immunology, 1986AbstractSuccessful antigen presentation by xenogeneic human antigen‐presenting cells (APC) to stimulate the proliferation of antigen‐specific, keyhole limpet hemocyanin (KLH)‐specific, ovelbumin (OVA)‐specific, and purified protein derivative of Mycobacterium tuberculosis (PPD)‐specific murine T cells was observed.
Akihiko Yano, Kouji Yabu
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B cells as antigen presenting cells
Cellular Immunology, 2005Several characteristics confer on B cells the ability to present antigen efficiently: (1) they can find T cells in secondary lymphoid organs shortly after antigen entrance, (2) BCR-mediated endocytosis allows them to concentrate small amounts of specific antigen, and (3) BCR signaling and HLA-DO expression direct their antigen processing machinery to ...
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Immunology Letters, 1995
Intracellular calcium ion mobilization in T-cell hybridomas and antigen-presenting cells (APC) during the interaction was observed using confocal fluorescence microscopy. No calcium signal was detected in non-activated T-cell hybridomas by antigen presentation.
Chikako Torigoe +2 more
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Intracellular calcium ion mobilization in T-cell hybridomas and antigen-presenting cells (APC) during the interaction was observed using confocal fluorescence microscopy. No calcium signal was detected in non-activated T-cell hybridomas by antigen presentation.
Chikako Torigoe +2 more
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Antigen Presentation and T Cell Stimulation by Dendritic Cells
Annual Review of Immunology, 2002Dendritic cells take up antigens in peripheral tissues, process them into proteolytic peptides, and load these peptides onto major histocompatibility complex (MHC) class I and II molecules. Dendritic cells then migrate to secondary lymphoid organs and become competent to present antigens to T lymphocytes, thus initiating antigen-specific immune ...
Guermonprez, P +4 more
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Artificial Antigen-Presenting Cells for Immunotherapies
2017Artificial antigen-presenting cells (aAPCs) overcome many of the limitations of biologically based adoptive immunotherapy protocols. While these acellular systems can be designed with a variety of parameters, including material type, diameter, and proliferative signals for T cells, we outline methods to formulate and characterize a comprehensive ...
Dongin Kim +3 more
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Antigen-presenting cells and T cell activation [PDF]
Agents and Actions, 1986 G. Huegli +3 more
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