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Cellular Assays to Monitor Antigen Cross-presentation In Vitro
Antigen cross-presentation is a functional feature of some specialized antigen-presenting cells, allowing them to internalize and process antigens from extracellular sources and present them via major histocompatibility class I (MHC-I) molecules to CD8+ T lymphocytes.François-Xavier, Mauvais +1 more
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Antigen Cross-Presentation and Heat Shock Protein-Based Vaccines
Archivum Immunologiae et Therapiae Experimentalis, 2015Vaccines currently in the clinical use contain adjuvants stimulating preferably Th2 type of immune response associated with the production of specific antibodies, mostly of neutralizing isotypes. This kind of immune response is effective only against some types of pathogens and has limited effect against tumors and many viruses where parallel ...
Katerina, Zachova +2 more
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Preparing Antigens Suitable for Cross-presentation Assays In Vitro and In Vivo
2012Cross-presentation is defined as the ability of certain professional antigen-presenting cells to take up, process and present extracellular antigens on major histocompatibility class I (MHC-I) molecules to CD8+ T cells. The stimulation of naive cytotoxic CD8+ T cells by this process, termed cross-priming, is involved in many different responses ...
Loredana, Saveanu, Peter, van Endert
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Introduction to the special issue: Antigen cross-presentation
Seminars in Immunology, 2023openaire +2 more sources
Mechanisms of Hsp70-Mediated Antigen Cross-Presentation
2007Hsp70 is a highly conserved, ubiquitous molecule and its properties as a molecular chaperone are well-described. Additionally, it has been shown to carry out important functions in the mammalian immune system. This study addressed several open questions concerning the interaction of Hsp70 with the surface of antigen presenting cells and the mechanism ...
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Analysis of direct and cross-presentation of antigens in TPPII knockout mice.
Journal of immunology (Baltimore, Md. : 1950), 2007Tripeptidyl peptidase II (TPPII) is an oligopeptidase forming giant complexes in the cytosol that have high exo-, but also, endoproteolytic activity. Immunohistochemically, the complexes appear as distinct foci in the cytosol. In part controversial biochemical and functional studies have suggested that TPPII contributes, on the one hand, positively to ...
Firat, Elke +7 more
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Alveolar macrophages instruct CD8+ T cell expansion by antigen cross-presentation in lung
Cell Reports, 2022Masahiro Kitabatake
exaly
Mechanism of cross-presentation of microencapsulated antigen
Journal of Controlled Release, 2011openaire +2 more sources
Spotlight on TAP and its vital role in antigen presentation and cross-presentation
Molecular Immunology, 2022Barzan A Sadiq +2 more
exaly
A proteasome‐dependent, TAP‐independent pathway for cross‐presentation of phagocytosed antigen
EMBO Reports, 2011Loredana Saveanu, Peter van Endert
exaly