Results 231 to 240 of about 6,214,641 (266)

Material‐Encoded Synchronization of Immunogenic Cell Death With Adenosine A2A Receptor Blockade Reprograms the Tumor Microenvironment

Advanced Science, EarlyView.
A bismuth–copper diselenide–based nanoplatform (BSCS@PHY) coordinates immunogenic cell death with local A2A receptor blockade in 4T1 tumors. Thermally triggered shell melting exposes catalytic surfaces for glutathione depletion and chemodynamic ROS generation, while co‐delivering an A2AR antagonist and yeast‐wall adjuvant to enhance dendritic‐cell ...
Xiangting Yi, Hanlou Yang, Junting Huang, Pengfei Wu, Shiying Zhou, Zunde Liao, Min Han, Zishan Chen, Xiaoyu Huang, Nan Ma, Jie Zhou, Mingqiang Li, Yiling Zhong   +12 more
wiley   +1 more source

Matrix Stiffness Induces Endothelial Network Senescence

Advanced Science, EarlyView.
Using a 3D human in vitro model that decouples mechanical stress from inflammatory or biochemical signals, matrix stiffening induces a senescence phenotype in endothelial networks. This mechano‐induced senescence activates Notch signaling, and pharmacologic Notch inhibition attenuates this stiffness‐induced senescence.
Jiyeon Song, Alexandra N. Rindone, Ya Guan, Connor D. Amelung, Prarthana Sanjay Daswani, Jennifer H. Elisseeff, Sharon Gerecht   +6 more
wiley   +1 more source

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Cross-presentation of Exogenous Antigens

Transfusion Clinique et Biologique, 2019
Presentation of exogenous antigens loaded on major histocompatibility complex class I molecules by antigen presenting cells, termed cross-presentation, is essential for the induction of CD8+ T cells and is performed mainly by specialized dendritic cell subsets.
B, Li, L, Hu
openaire   +2 more sources

Cross-Presentation of Antigens by Dendritic Cells

Critical Reviews™ in Immunology, 2002
T lymphocytes recognize antigen presented on the surface of antigen-presenting cells byMHC class I and class II molecules. Classically, MHC class I molecules present self- or pathogen-derived antigens that are synthesized within the cell, whereas exogenous antigens derived via endocytic uptake are loaded onto MHC class II molecules for presentation to ...
Belz, Gabrielle T., Carbone, Francis R., Heath, William R.   +2 more
openaire   +3 more sources

Phagosomes are competent organelles for antigen cross-presentation

Nature, 2003
The ability to process microbial antigens and present them at the surface of cells is an important aspect of our innate ability to clear infections. It is generally accepted that antigens in the cytoplasm are loaded in the endoplasmic reticulum and presented at the cell surface on major histocompatibility complex (MHC) class I molecules, whereas ...
Mathieu, Houde, Sylvie, Bertholet, Etienne, Gagnon, Sylvain, Brunet, Guillaume, Goyette, Annie, Laplante, Michael F, Princiotta, Pierre, Thibault, David, Sacks, Michel, Desjardins   +9 more
openaire   +2 more sources

The ins-and-outs of endosomal antigens for cross-presentation

Current Opinion in Immunology, 2014
The efficiency of antigen cross-presentation, which is the presentation of extracellular antigens on MHC I molecules, critically depends on the stability of the internalized antigens. Since rapid degradation within the lysosomal compartment impairs cross-presentation, potent cross-presenting cells display several mechanisms to prevent activation of ...
Verena, Schuette, Sven, Burgdorf
openaire   +2 more sources

Pathways of MHC I cross-presentation of exogenous antigens

Seminars in Immunology, 2023
Phagocytes, particularly dendritic cells (DCs), generate peptide-major histocompatibility complex (MHC) I complexes from antigens they have collected from cells in tissues and report this information to CD8 T cells in a process called cross-presentation. This process allows CD8 T cells to detect, respond and eliminate abnormal cells, such as cancers or
Freidrich M, Cruz, Amanda, Chan, Kenneth L, Rock   +2 more
openaire   +2 more sources

The pathway of cross‐presentation is influenced by the particle size of phagocytosed antigen [PDF]

Immunology, 2012
SummaryCross‐presentation is the presentation by MHC class I of antigenic peptides from exogenous proteins that have been internalized and processed by professional antigen‐presenting cells, e.g. dendritic cells. We have investigated the influence of particle size and antigen load on cross‐presentation following antigen delivery on microspheres (MS ...
Alexandra Mant, Tim Elliott
exaly   +4 more sources

Development of antigen cross-presentation capacity in dendritic cells

Trends in Immunology, 2012
Cross-presentation by dendritic cells (DCs) of exogenous antigens on MHC class I is important for the generation of immune responses to intracellular pathogens, as well as for maintenance of self tolerance. In mice, the CD8(+) DC lineage is specialised for this role. However, DCs of this lineage are not born with cross-presentation capacity.
Dresch, C, Leverrier, Yann, Marvel, Jacqueline, Shortman, Ken   +3 more
openaire   +3 more sources

Antigen cross-presentation: extending recent laboratory findings to therapeutic intervention

Clinical and Experimental Immunology, 2011
Summary The initiation of adaptive immune responses requires antigen presentation to lymphocytes. In particular, dendritic cells (DCs) are equipped with specialized machinery that promote effective display of peptide/major ...
Ewoud Compeer, Jaap Jan Boelens
exaly   +2 more sources