Results 241 to 250 of about 6,214,641 (266)
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Cellular mechanisms governing cross-presentation of exogenous antigens
Nature Immunology, 2004The recent discovery of fusion of endoplasmic reticulum membrane with nascent phagosomes suggests that this peripheral compartment in macrophages and dendritic cells may serve as an organelle optimized for major histocompatibility complex (MHC) class I-restricted cross-presentation of exogenous antigens. The process allows intersection of the endosomal
Anne L, Ackerman, Peter, Cresswell
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Engineering nanoparticulate vaccines for enhancing antigen cross-presentation
Current Opinion in Biotechnology, 2020Efficient cross-presentation is pivotal for vaccination against cancer and infection by intracellular virus and bacteria. Recently, various types of nanoparticle vaccines have been developed and investigated for efficiently and specifically improving cross-presentation and CD8+ T cell priming.
Guangsheng, Du, Xun, Sun
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Neonatal and adult microglia crossâpresent exogenous antigens
Glia, 2007AbstractSome observations have suggested that cells from the central nervous system (CNS) could present exogenous antigens on major histocompatibility complex (MHC) class I molecules to CD8+ T cells (a process called crossâpresentation). Microglia are the major myeloid immunocompetent cells of the CNS.
Beauvillain, Celine +8 more
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Induction of antigen cross-presentation by Toll-like receptors
Springer Seminars in Immunopathology, 2004Cross-presentation is the pathway by which exogenous antigens are routed for presentation on MHC class I for activation of CD8(+) T cells. This pathway is important for the development of CD8(+) cytotoxic T lymphocyte responses against tumors and infectious pathogens that do not directly infect APC.
Sandip K, Datta, Eyal, Raz
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Cross presentation of antigen by dendritic cells: mechanisms and implications for immunotherapy
Expert Review of Clinical Immunology, 2012 Dendritic cells (DCs) possess the specialized potential to present exogenously derived antigen to cytotoxic T lymphocytes to elicit an immune response. This process, termed cross presentation, is crucial in the generation of immune response to viruses, tumors and in autoimmune disease.
Paul Fairchild
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Serpinb9 is a marker of antigen cross-presenting dendritic cells
Molecular Immunology, 2017Serpinb9 (Sb9, also called Spi6) is an intracellular inhibitor of granzyme B (grB) that protects cytotoxic lymphocytes from grB-mediated death. In addition, Sb9 is also expressed in accessory immune cells, including dendritic cells (DCs), although its role is debated.
M S, Mangan +9 more
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Intracellular mechanisms of antigen cross presentation in dendritic cells
Current Opinion in Immunology, 2010The induction of most CD8+ T cell responses by dendritic cells (DCs) requires the presentation of peptides from internalized antigen by class I MHC molecules. Increasing number of reports have shown that cross presentation is involved in transplant rejection, in immune responses to viral infections, in certain autoimmune diseases and cancer.
Amigorena S, and Savina A
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Phagocytic neutrophils cross-present antigen
Blood, 2007In this issue of Blood , Beauvillain and colleagues show that murine as well as human neutrophils are capable of cross-presenting exogenous antigens to CD8+ T cells. Neutrophils are the main inflammatory cells responsible for pathogen killing at sites of infection.
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Cross-Presentation of Cell-Associated Antigens by Dendritic Cells
2003There is a strict requirement for professional antigen-presenting cells (APCs) in the generation of immunity toward most viruses. Exogenous pathways of MHC class I-restricted antigen presentation play an important role in the generation of antiviral immunity, particularly in the immune surveillance of virus-infected tissues of nonhematopoietic origin ...
M, Larsson, J F, Fonteneau, N, Bhardwaj
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The Role of Tomatine Adjuvant in Antigen Delivery for Cross- Presentation
Current Drug Delivery, 2015The aim of this study was to investigate the use of tomatine adjuvant to deliver soluble antigen for crosspresentation by bone marrow-derived dendritic cells (BMDCs). BMDCs were incubated with tomatine adjuvantovalbumin (OVA) complex and analyzed for antigen uptake by flow cytometry.
Paul Y-J, Hsu +3 more
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