Results 211 to 220 of about 176,845 (241)
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Cellular mechanisms governing cross-presentation of exogenous antigens
Nature Immunology, 2004The recent discovery of fusion of endoplasmic reticulum membrane with nascent phagosomes suggests that this peripheral compartment in macrophages and dendritic cells may serve as an organelle optimized for major histocompatibility complex (MHC) class I-restricted cross-presentation of exogenous antigens. The process allows intersection of the endosomal
Anne L, Ackerman, Peter, Cresswell
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Cross presentation of antigen by dendritic cells: mechanisms and implications for immunotherapy
Expert Review of Clinical Immunology, 2012 Dendritic cells (DCs) possess the specialized potential to present exogenously derived antigen to cytotoxic T lymphocytes to elicit an immune response. This process, termed cross presentation, is crucial in the generation of immune response to viruses, tumors and in autoimmune disease.
Paul Fairchild
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Cross-Presentation of Cell-Associated Antigens by Dendritic Cells
2003There is a strict requirement for professional antigen-presenting cells (APCs) in the generation of immunity toward most viruses. Exogenous pathways of MHC class I-restricted antigen presentation play an important role in the generation of antiviral immunity, particularly in the immune surveillance of virus-infected tissues of nonhematopoietic origin ...
M, Larsson, J F, Fonteneau, N, Bhardwaj
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The Role of Tomatine Adjuvant in Antigen Delivery for Cross- Presentation
Current Drug Delivery, 2015The aim of this study was to investigate the use of tomatine adjuvant to deliver soluble antigen for crosspresentation by bone marrow-derived dendritic cells (BMDCs). BMDCs were incubated with tomatine adjuvantovalbumin (OVA) complex and analyzed for antigen uptake by flow cytometry.
Paul Y-J, Hsu +3 more
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Phagocytic neutrophils cross-present antigen
Blood, 2007In this issue of Blood , Beauvillain and colleagues show that murine as well as human neutrophils are capable of cross-presenting exogenous antigens to CD8+ T cells. Neutrophils are the main inflammatory cells responsible for pathogen killing at sites of infection.
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Development of antigen cross-presentation capacity in dendritic cells
Trends in Immunology, 2012Cross-presentation by dendritic cells (DCs) of exogenous antigens on MHC class I is important for the generation of immune responses to intracellular pathogens, as well as for maintenance of self tolerance. In mice, the CD8(+) DC lineage is specialised for this role. However, DCs of this lineage are not born with cross-presentation capacity.
Dresch, C +3 more
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Serpinb9 is a marker of antigen cross-presenting dendritic cells
Molecular Immunology, 2017Serpinb9 (Sb9, also called Spi6) is an intracellular inhibitor of granzyme B (grB) that protects cytotoxic lymphocytes from grB-mediated death. In addition, Sb9 is also expressed in accessory immune cells, including dendritic cells (DCs), although its role is debated.
M S, Mangan +9 more
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Intracellular mechanisms of antigen cross presentation in dendritic cells
Current Opinion in Immunology, 2010The induction of most CD8+ T cell responses by dendritic cells (DCs) requires the presentation of peptides from internalized antigen by class I MHC molecules. Increasing number of reports have shown that cross presentation is involved in transplant rejection, in immune responses to viral infections, in certain autoimmune diseases and cancer.
Amigorena S, and Savina A
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Induction of antigen cross-presentation by Toll-like receptors
Springer Seminars in Immunopathology, 2004Cross-presentation is the pathway by which exogenous antigens are routed for presentation on MHC class I for activation of CD8(+) T cells. This pathway is important for the development of CD8(+) cytotoxic T lymphocyte responses against tumors and infectious pathogens that do not directly infect APC.
Sandip K, Datta, Eyal, Raz
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hDectin-1 is involved in uptake and cross-presentation of cellular antigens
Blood, 2008AbstractHuman Dectin-1 (hDectin-1) is a member of the C-type lectin–like receptor family that was shown to be the major receptor for fungal beta-glucans and to play an important role in the cellular responses mediated by these carbohydrates. In this study, we demonstrate that hDectin-1 is involved in the uptake and cross-presentation of cellular ...
Markus M, Weck +6 more
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