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Regulation of the Cell Biology of Antigen Cross-Presentation [PDF]

Annual Review of Immunology, 2018
Antigen cross-presentation is an adaptation of the cellular process of loading MHC-I molecules with endogenous peptides during their biosynthesis within the endoplasmic reticulum. Cross-presented peptides derive from internalized proteins, microbial pathogens, and transformed or dying cells.
J Magarian Blander
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Antigen Cross-Presentation by Dendritic Cell Subsets: One General or All Sergeants?

Trends in Immunology, 2013
Item does not contain fulltextAntigen cross-presentation describes the process through which dendritic cells (DCs) acquire exogenous antigens for presentation on MHC class I molecules.
Jurjen Tel, Stefan Nierkens
exaly   +2 more sources

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Cross-presentation of Exogenous Antigens

Transfusion Clinique et Biologique, 2019
Presentation of exogenous antigens loaded on major histocompatibility complex class I molecules by antigen presenting cells, termed cross-presentation, is essential for the induction of CD8+ T cells and is performed mainly by specialized dendritic cell subsets.
B, Li, L, Hu
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Cross-Presentation of Antigens by Dendritic Cells

Critical Reviews™ in Immunology, 2002
T lymphocytes recognize antigen presented on the surface of antigen-presenting cells byMHC class I and class II molecules. Classically, MHC class I molecules present self- or pathogen-derived antigens that are synthesized within the cell, whereas exogenous antigens derived via endocytic uptake are loaded onto MHC class II molecules for presentation to ...
Belz, Gabrielle T., Carbone, Francis R., Heath, William R.   +2 more
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Perforin 2 Mediates Endosomal Antigen Export for Cross-Presentation

Nature Reviews Immunology, 2023
Sarah Rowland-Jones, Aljawharah Alrubayyi   +1 more
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The ins-and-outs of endosomal antigens for cross-presentation

Current Opinion in Immunology, 2014
The efficiency of antigen cross-presentation, which is the presentation of extracellular antigens on MHC I molecules, critically depends on the stability of the internalized antigens. Since rapid degradation within the lysosomal compartment impairs cross-presentation, potent cross-presenting cells display several mechanisms to prevent activation of ...
Verena, Schuette, Sven, Burgdorf
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Phagosomes are competent organelles for antigen cross-presentation

Nature, 2003
The ability to process microbial antigens and present them at the surface of cells is an important aspect of our innate ability to clear infections. It is generally accepted that antigens in the cytoplasm are loaded in the endoplasmic reticulum and presented at the cell surface on major histocompatibility complex (MHC) class I molecules, whereas ...
Mathieu, Houde, Sylvie, Bertholet, Etienne, Gagnon, Sylvain, Brunet, Guillaume, Goyette, Annie, Laplante, Michael F, Princiotta, Pierre, Thibault, David, Sacks, Michel, Desjardins   +9 more
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Pathways of MHC I cross-presentation of exogenous antigens

Seminars in Immunology, 2023
Phagocytes, particularly dendritic cells (DCs), generate peptide-major histocompatibility complex (MHC) I complexes from antigens they have collected from cells in tissues and report this information to CD8 T cells in a process called cross-presentation. This process allows CD8 T cells to detect, respond and eliminate abnormal cells, such as cancers or
Freidrich M, Cruz, Amanda, Chan, Kenneth L, Rock   +2 more
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Engineering nanoparticulate vaccines for enhancing antigen cross-presentation

Current Opinion in Biotechnology, 2020
Efficient cross-presentation is pivotal for vaccination against cancer and infection by intracellular virus and bacteria. Recently, various types of nanoparticle vaccines have been developed and investigated for efficiently and specifically improving cross-presentation and CD8+ T cell priming.
Guangsheng, Du, Xun, Sun
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Neonatal and adult microglia cross‐present exogenous antigens

Glia, 2007
AbstractSome observations have suggested that cells from the central nervous system (CNS) could present exogenous antigens on major histocompatibility complex (MHC) class I molecules to CD8+ T cells (a process called cross‐presentation). Microglia are the major myeloid immunocompetent cells of the CNS.
Beauvillain, Celine, Donnou, Sabrina, Jarry, Ulrich, Scotet, Mari, Gascan, Hugues, Delneste, Yves, Guermonprez, Pierre, Jeannin, Pascale, Couez, Dominique   +8 more
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