Results 201 to 210 of about 176,845 (241)

The Host Cell Factor Phosphatase‐2A Subunit PR130 Restricts Replication of Herpes Simplex Virus Type‐1

Advanced Science, EarlyView.
Molecular, genetic, virological, and biochemical analysis in combination with global proteome and phosphoproteome profiling and functional assays were applied to study the role of PR130 in the context of HSV‐1 replication. The observations reveal that host‐intrinsic mechanisms regulate HSV‐1 replication and highlight PR130 as a susceptibility factor of
Johannes Jungwirth, Christoph F. Jacob, Alexandra Nguyen, Mandy Beyer, Andreas O. Mieland, Mario Dejung, Jia‐Xuan Chen, Walburgis Brenner, Christina Ehrhardt, Andreas Henke, Oliver H. Krämer   +10 more
wiley   +1 more source

Single‐Cell Transcriptomic Analysis of Tumor Heterogeneity and the Microenvironment in Pseudomyxoma Peritonei

Advanced Science, EarlyView.
This study presents a single‐cell atlas of pseudomyxoma peritonei spanning primary and paired metastatic lesions. Distinct epithelial substates, stromal remodeling, immune exclusion, lipid metabolic reprogramming, and a candidate angiogenic network were identified in metastatic lesions.
Xi Li, Lei Wang, Lei Ai, Zimeng Li, Zhaochangci Chen, Yuchen Luo, Tianran Zhang, Mengjia Liao, Songhao Wang, Jiajia Cui, Ke Liu, Chengxian Guo, Guodong Liu, Jiye Yin, Wei Wu   +14 more
wiley   +1 more source

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Cross-presentation of Exogenous Antigens

Transfusion Clinique et Biologique, 2019
Presentation of exogenous antigens loaded on major histocompatibility complex class I molecules by antigen presenting cells, termed cross-presentation, is essential for the induction of CD8+ T cells and is performed mainly by specialized dendritic cell subsets.
B, Li, L, Hu
openaire   +2 more sources

Pathways for antigen cross presentation

Springer Seminars in Immunopathology, 2004
Dendritic cells (DCs) have the unique ability to capture cellular tissue antigens, and to present them on MHC class I molecules to antigen-specific CD8(+) T lymphocytes after migration to the draining lymph nodes. This process, called "cross presentation" can lead either to the tolerization or activation of antigen-specific CD8(+) T cells.
Guermonprez, P, Amigorena, S
openaire   +3 more sources

Cross-Presentation of Antigens by Dendritic Cells

Critical Reviews™ in Immunology, 2002
T lymphocytes recognize antigen presented on the surface of antigen-presenting cells byMHC class I and class II molecules. Classically, MHC class I molecules present self- or pathogen-derived antigens that are synthesized within the cell, whereas exogenous antigens derived via endocytic uptake are loaded onto MHC class II molecules for presentation to ...
Belz, Gabrielle T., Carbone, Francis R., Heath, William R.   +2 more
openaire   +3 more sources

Phagosomes are competent organelles for antigen cross-presentation

Nature, 2003
The ability to process microbial antigens and present them at the surface of cells is an important aspect of our innate ability to clear infections. It is generally accepted that antigens in the cytoplasm are loaded in the endoplasmic reticulum and presented at the cell surface on major histocompatibility complex (MHC) class I molecules, whereas ...
Mathieu, Houde, Sylvie, Bertholet, Etienne, Gagnon, Sylvain, Brunet, Guillaume, Goyette, Annie, Laplante, Michael F, Princiotta, Pierre, Thibault, David, Sacks, Michel, Desjardins   +9 more
openaire   +2 more sources

Pathways of MHC I cross-presentation of exogenous antigens

Seminars in Immunology, 2023
Phagocytes, particularly dendritic cells (DCs), generate peptide-major histocompatibility complex (MHC) I complexes from antigens they have collected from cells in tissues and report this information to CD8 T cells in a process called cross-presentation. This process allows CD8 T cells to detect, respond and eliminate abnormal cells, such as cancers or
Freidrich M, Cruz, Amanda, Chan, Kenneth L, Rock   +2 more
openaire   +2 more sources

The ins-and-outs of endosomal antigens for cross-presentation

Current Opinion in Immunology, 2014
The efficiency of antigen cross-presentation, which is the presentation of extracellular antigens on MHC I molecules, critically depends on the stability of the internalized antigens. Since rapid degradation within the lysosomal compartment impairs cross-presentation, potent cross-presenting cells display several mechanisms to prevent activation of ...
Verena, Schuette, Sven, Burgdorf
openaire   +2 more sources

Neonatal and adult microglia cross‐present exogenous antigens

Glia, 2007
AbstractSome observations have suggested that cells from the central nervous system (CNS) could present exogenous antigens on major histocompatibility complex (MHC) class I molecules to CD8+ T cells (a process called cross‐presentation). Microglia are the major myeloid immunocompetent cells of the CNS.
Beauvillain, Celine, Donnou, Sabrina, Jarry, Ulrich, Scotet, Mari, Gascan, Hugues, Delneste, Yves, Guermonprez, Pierre, Jeannin, Pascale, Couez, Dominique   +8 more
openaire   +3 more sources

Engineering nanoparticulate vaccines for enhancing antigen cross-presentation

Current Opinion in Biotechnology, 2020
Efficient cross-presentation is pivotal for vaccination against cancer and infection by intracellular virus and bacteria. Recently, various types of nanoparticle vaccines have been developed and investigated for efficiently and specifically improving cross-presentation and CD8+ T cell priming.
Guangsheng, Du, Xun, Sun
openaire   +2 more sources