Results 101 to 110 of about 506,623 (257)
Exploration of heterogeneity and recurrence signatures in hepatocellular carcinoma
Molecular Oncology, EarlyView.This study leveraged public datasets and integrative bioinformatic analysis to dissect malignant cell heterogeneity between relapsed and primary HCC, focusing on intercellular communication, differentiation status, metabolic activity, and transcriptomic profiles.
Wen‐Jing Wu +15 more
wiley +1 more source
Current Concepts of Antigen Cross-Presentation
Frontiers in Immunology, 2018 Dendritic cells have the ability to efficiently present internalized antigens on major histocompatibility complex (MHC) I molecules. This process is termed cross-presentation and is important role in the generation of an immune response against viruses ...
Maria Embgenbroich, Sven Burgdorf
doaj +1 more source
ETEC colonisation factors disrupt the antigen presenting capacity of porcine intestinal dendritic cells [PDF]
, 2012 Enterotoxigenic E. coli (ETEC) are not only a major cause of diarrhoea in travellers to and children in developing countries, but also cause neonatal and postweaning diarrhoea in piglets, leading to a reduced feed conversion and a higher mortality rate ...
Baert, Kim, Devriendt, Bert, Luo, Yu
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Molecular Oncology, EarlyView.TGF‐β has a complex role in cancer, exhibiting both tumor‐suppressive and tumor‐promoting properties. Using a series of differentiated tumoroids, derived from different stages and mutational background of colorectal cancer patients, we replicate this duality of TGF‐β in vitro. Notably, the atypical but highly aggressive KRASQ22K mutation rendered early‐
Theresia Mair +17 more
wiley +1 more source
Molecular Oncology, EarlyView.There is an unmet need in metastatic breast cancer patients to monitor therapy response in real time. In this study, we show how a noninvasive and affordable strategy based on sequencing of plasma samples with longitudinal tracking of tumour fraction paired with a statistical model provides valuable information on treatment response in advance of the ...
Emma J. Beddowes +20 more
wiley +1 more source
MHC presentation via autophagy and how viruses escape from it [PDF]
, 2018 T cells detect infected and transformed cells via antigen presentation by major histocompatibility complex (MHC) molecules on the cell surface. For T cell stimulation, these MHC molecules present fragments of proteins that are expressed or taken up by ...
Gannage, Monique, Münz, Christian
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Functional Cellular Anti-Tumor Mechanisms are Augmented by Genetic Proteoglycan Targeting. [PDF]
, 2020 While recent research points to the importance of glycans in cancer immunity, knowledge on functional mechanisms is lacking. In lung carcinoma among other tumors, anti-tumor immunity is suppressed; and while some recent therapies boost T-cell mediated ...
El Ghazal, Roland +5 more
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Presentation of an Immunodominant Immediate-Early CD8+ T Cell Epitope Resists Human Cytomegalovirus Immunoevasion. [PDF]
, 2013 Control of human cytomegalovirus (HCMV) depends on CD8+ T cell responses that are shaped by an individual's repertoire of MHC molecules. MHC class I presentation is modulated by a set of HCMV-encoded proteins.
Ameres, Stefanie +6 more
core +3 more sources
CD40-stimulated B Lymphocytes Pulsed with Tumor Antigens Are Effective Antigen-presenting Cells That Can Generate Specific T Cells [PDF]
, 2003 Although they are considered as antigen presenting cells (APC), the role of antigen-unspecific B-lymphocytes in antigen presentation and T lymphocyte stimulation remains controversial.
Bellemare-Pelletier, Angélique +4 more
core +1 more source
Antigen presentation by hapten-specific B lymphocytes. I. Role of surface immunoglobulin receptors. [PDF]
, 1984 The present study examines the ability of hapten-specific murine splenic B lymphocytes to present hapten-proteins to carrier-specific T cell hybridomas.
Abbas, AK, Benacerraf, B, Rock, KL
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