Results 91 to 100 of about 534,463 (213)

Antigen presentation [PDF]

Current Biology, 1998
openaire   +3 more sources

Rational design of topology-defined DNA nanoframeworks for antigen delivery and cross-presentation

Journal of Nanobiotechnology
DNA nanoframeworks (DNFs) provide structurally programmable platforms for antigen delivery, yet how framework topology influences antigen cross-presentation remains unclear.
Ying Cao, Yuanyuan Wu, Xian Huang, Kui Huang, Tomasz Maj, Zhao Xu, Jingwei Sun, Qian Shi, Yang Yang   +8 more
doaj   +1 more source

Tapasin - The star of the show in HLA-I maturation [Elektronisk resurs] [PDF]

, 2015
Human leukocyte antigen class I (HLA-I) molecules are present on the cell surface of all nucleated cells. They bind intracellular peptides and present them to the immune system thus providing a readout to cytotoxic T-cells about the status of a cell ...
Lund University., Thuring, Camilla,
core  

Modulation of cytomegalovirus immune evasion identifies direct antigen presentation as the predominant mode of CD8 T-cell priming during immune reconstitution after hematopoietic cell transplantation

Frontiers in Immunology
Cytomegalovirus (CMV) infection is the most critical infectious complication in recipients of hematopoietic cell transplantation (HCT) in the period between a therapeutic hematoablative treatment and the hematopoietic reconstitution of the immune system.
Rafaela Holtappels, Julia K. Büttner, Kirsten Freitag, Matthias J. Reddehase, Niels A. Lemmermann, Niels A. Lemmermann   +5 more
doaj   +1 more source

ERα blockade in dendritic cells enhances antigen cross-presentation and induces antitumor CD8+ T cell immunity

Nature Communications
Dendritic cells (DC) dysfunction impedes antitumor immunity, so understanding intrinsic regulators of DC antigen presentation and the resulting activation of antitumor CD8+ T cells could benefit therapy.
Yaxin Liu, Zhongfei Ma, Xuelian Li, Yuanyuan Ding, Zhiqing Li, Bin Zhang, Yumei Zhou, Jun Zhou, Shuo Liu, Shuxun Liu, Lianjun Zhang, Chunmei Wang, Xuetao Cao   +12 more
doaj   +1 more source

An escherichia coli vaccine co-expressing listeriolysin-O and tumour antigen in cancer immunotherapy and the mechanisms of immune regulation [PDF]

, 2009
PhDSome recombinant bacterial strains have been shown to be very efficient in experimental therapies against cancer in rodent models. Amongst them is an E. coli that expresses the Listeriolysin-O protein (LLO) and a model tumour antigen ovalbumin (OVA)
Dai, Ming-Shen
core  

Tumor‐Derived CDC37 Inhibits Antigen Cross‐Presentation in Dendritic Cells and Impairs Anti‐Tumor Immunity in Breast Cancer

Advanced Science
Tumor mutational burden (TMB), usually representing high immunogenicity, cannot always predict treatment response of immune checkpoint blockade (ICB).
Ruxin Wang, Yunyi Zhang, Xiangyu Meng, Jianli Zhao, Yue Xing, Qian Ouyang, Ning Zhang, Huiping Chen, Nanyan Miao, Erwei Song, Di Huang   +10 more
doaj   +1 more source

Antigen presentation in the CNS [PDF]

Molecular Psychiatry, 1997
Frei K, Fontana A
openaire   +3 more sources

Artificial Antigen Presenting Cells With Preclustered anti-CD28/-CD3/-LFA-1 Monoclonal Antibodies Are Highly Effective To Induce The Ex-Vivo Expansion Of Functional Human Antitumor T Cells [PDF]

, 2007
Effective adoptive T cell therapy requires the _ex vivo_ generation of functional T lymphocytes with a long lifespan _in vivo_. We evaluated _in vitro_ T cell expansion by artificial antigen presenting cells (aAPC) generated with activating (human anti ...
Roberta Zappasodi, Carmelo Carlo-Stella, Lorena Passoni, Salvatore Albani, Claudia Vegetti, Massimo Di Nicola, Alessandro M. Gianni, Roberta Mortarini, Alessandra Molla, Andrea Anichini   +9 more
core   +1 more source

Improved antigen cross-presentation by polyethyleneimine-based nanoparticles

International Journal of Nanomedicine, 2011
Jian Chen1, Zhengrong Li1, Hong Huang2, Yanzhu Yang2, Qian Ding2, Junhua Mai1, Wei Guo2, Yuhong Xu21School of Life Sciences and Biotechnology, 2School of Pharmacy, Shanghai Jiao Tong University, Shanghai, People's Republic of ChinaPurpose: In the
Jian Chen, Zhengrong Li, Hong Huang, et al   +3 more
doaj