Presentation of an Immunodominant Immediate-Early CD8+ T Cell Epitope Resists Human Cytomegalovirus Immunoevasion. [PDF]
, 2013 Control of human cytomegalovirus (HCMV) depends on CD8+ T cell responses that are shaped by an individual's repertoire of MHC molecules. MHC class I presentation is modulated by a set of HCMV-encoded proteins.
Ameres, Stefanie +27 more
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CPAF selectively degrades chlamydial T cell antigens for inhibiting antigen presentation
Journal of Infection in Developing Countries, 2017 Introduction: Chlamydia trachomatis is the leading cause of sexually transmitted bacterial disease, which may cause significant threats, such as pelvic inflammatory disease and tubal factor infertility, to women if untreated. The pathological mechanisms
Yuyang Zhang +6 more
doaj +1 more source
THE LYMPH SELF ANTIGEN REPERTOIRE
Frontiers in Immunology, 2013 The lymphatic fluid originates from the interstitial fluid which bathes every parenchymal organ and reflects the omic composition of the tissue from which it originates in its physiological or pathological signature.
Laura eSantambrogio, Cristina eClement
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Antigen-Presentation Properties of Plasmacytoid Dendritic Cells [PDF]
, 2008 One of the remaining enigmas of the dendritic cell (DC) network is the potential contribution of plasmacytoid DCs (pDCs) to antigen presentation. Although the antigen-presentation capacity of conventional DCs (cDCs) is clearly defined, pDCs are generally
Villadangos, José A., Young, Louise
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Tapasin - The star of the show in HLA-I maturation [PDF]
, 2015 Human leukocyte antigen class I (HLA-I) molecules are present on the cell surface of all nucleated cells. They bind intracellular peptides and present them to the immune system thus providing a readout to cytotoxic T-cells about the status of a cell ...
Thuring, Camilla
core
Efficient processing of an antigenic sequence for presentation by MHC class I molecules depends on its neighboring residues in the protein [PDF]
, 1991 Processing of endogenously synthesized proteins generates short peptides that are presented by MHC class I molecules to CD8 T lymphocytes. Here it is documented that not only the sequence of the presented peptide but also the residues by which it is ...
Reddehase, Matthias J. +4 more
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Cloned long-term cytolytic T-lymphocyte line with specificity for an immediate-early membrane antigen of murine cytomegalovirus [PDF]
, 1986 Long-term cytolytic T-lymphocyte (CTL) lines that are specific for distinct antigens associated with different phases of the replicative cycle of the murine cytomegalovirus (MCMV) were established by cloning of CTL lines derived from lymph nodes of ...
Reddehase, Matthias J. +2 more
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Alum increases antigen uptake, reduces antigen degradation and sustains antigen presentation by DCs in vitro [PDF]
, 2012 Aluminium adjuvants (alum) have been the only widely approved adjuvants for use in human vaccines since the 1920s, however, the mechanism of action of these adjuvants remains elusive.
Ghimire, T.R. +11 more
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, 1987 Antigen presentation is a critical step in the initiation of immune response. Many types of cells can serve this function but the macrophages are the principal cells.
Mathur, A. +2 more
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Immune-Complex Mimics as a Molecular Platform for Adjuvant-Free Vaccine Delivery [PDF]
, 2013 Protein-based vaccine development faces the difficult challenge of finding robust yet non-toxic adjuvants suitable for humans. Here, using a molecular engineering approach, we have developed a molecular platform for generating self-adjuvanting immunogens
Stylianou, E +26 more
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