Results 111 to 120 of about 3,217,603 (374)

931 Augmenting antigen presentation to improve CD8⁺and CD4⁺T cell responses in lung cancer [PDF]

, 2023
Sean-Luc Shanahan, Jason M. Schenkel, Tyler Jacks   +2 more
openalex   +1 more source

Antigen presentation and adaptive immune responses in skin.

International Immunology, 2019
For the induction of adequate cutaneous immune responses, the antigen presentation and recognition that occur in both the skin and skin-draining lymph nodes are essential.
T. Honda, G. Egawa, K. Kabashima
semanticscholar   +1 more source

Improving PARP inhibitor efficacy in bladder cancer without genetic BRCAness by combination with PLX51107

Molecular Oncology, EarlyView.
Clinical trials on PARP inhibitors in urothelial carcinoma (UC) showed limited efficacy and a lack of predictive biomarkers. We propose SLFN5, SLFN11, and OAS1 as UC‐specific response predictors. We suggest Talazoparib as the better PARP inhibitor for UC than Olaparib.
Jutta Schmitz, Anna L. Bartkowiak, Michael Rose, Nora Kolks, Patrick Petzsch, Vandana Solanki, Anne Stoffel, Bianca Faßbender, Leandra Lepping, Julka Volkamer, Karl Köhrer, Marc Seifert, Tokameh Mahmoudi, Tahlita C. M. Zuiverloon, Günter Niegisch, Michèle J. Hoffmann   +15 more
wiley   +1 more source

Covering All the Bases: Complementary MR1 Antigen Presentation Pathways Sample Diverse Antigens and Intracellular Compartments

Frontiers in Immunology, 2020
The ubiquitously expressed, monomorphic MHC class Ib molecule MHC class I-related protein 1 (MR1) presents microbial metabolites to mucosal-associated invariant T (MAIT) cells.
Corinna Kulicke, Corinna Kulicke, Elham Karamooz, Elham Karamooz, David Lewinsohn, David Lewinsohn, David Lewinsohn, David Lewinsohn, Melanie Harriff, Melanie Harriff, Melanie Harriff   +10 more
doaj   +1 more source

Structure-based selection of human metabolite binding P4 pocket of DRB1*15:01 and DRB1*15:03, with implications for multiple sclerosis. [PDF]

, 2018
Binding of small molecules in the human leukocyte antigen (HLA) peptide-binding groove may result in conformational changes of bound peptide and an altered immune response, but previous studies have not considered a potential role for endogenous ...
Damotte, Vincent, Hollenbach, Jill, Misra, Maneesh   +2 more
core   +1 more source

Cytoplasmic p21 promotes stemness of colon cancer cells via activation of the NFκB pathway

Molecular Oncology, EarlyView.
Cytoplasmic p21 promotes colorectal cancer stem cell (CSC) features by destabilizing the NFκB–IκB complex, activating NFκB signaling, and upregulating BCL‐xL and COX2. In contrast to nuclear p21, cytoplasmic p21 enhances spheroid formation and stemness transcription factor CD133.
Arnatchai Maiuthed, Kerstin Huebner, Katharina Erlenbach‐Wuensch, Chuanpit Hampel, Daniela Thalheim, Adriana Vial‐Roehe, Bodee Nutho, Susanne Merkel, Arndt Hartmann, Pithi Chanvorachote, Regine Schneider‐Stock   +10 more
wiley   +1 more source

Peptide-MHC-I from Endogenous Antigen Outnumber Those from Exogenous Antigen, Irrespective of APC Phenotype or Activation.

PLoS Pathogens, 2015
Naïve anti-viral CD8+ T cells (TCD8+) are activated by the presence of peptide-MHC Class I complexes (pMHC-I) on the surface of professional antigen presenting cells (pAPC).
Janet J Sei, Scott Haskett, Lauren W Kaminsky, Eugene Lin, Mary E Truckenmiller, Clifford J Bellone, R Mark Buller, Christopher C Norbury   +7 more
doaj   +1 more source

Tumor derived Microvesicles enhance cross-processing ability of clinical grade Dendritic Cells [PDF]

, 2018
Tumor cells release extracellular microvesicles (MVs) in the microenvironment to deliver biological signals to neighbouring cells as well as to cells in distant tissues.
Battisti, Federico, Belleudi, Francesca, Claudia De Archangelis,, DI FILIPPO, Alessandra, Dionisi, Marco, Napoletano, Chiara, Nuti, Marianna, RAHIMI KOSHKAKI, Hassan, Rughetti, Aurelia, Ruscito, Ilary, Torrisi, Maria Rosaria, Zizzari, ILARIA GRAZIA   +11 more
core   +1 more source

Extrachromosomal DNA is associated with decreased immune cell infiltration and antigen presentation, represents a potential cancer immune evasion mechanism [PDF]

, 2022
Tao Wu, Chenxu Wu, Xiangyu Zhao, Guangshuai Wang, Ning Wei, Ziyu Tao, Fuxiang Chen, Xuesong Liu   +7 more
openalex   +1 more source

Antigen Presentation

Definitions, 2020
The phenotypic and functional studies carried out during recent years have highlighted the enormous heterogeneity among dendritic cells. These specialized cells possess a variety of features that make them highly efficient agents for the detection of ...
G. Belz, N. Wilson, F. Kupresanin, A. Mount, Christopher M. Smith   +4 more
semanticscholar   +1 more source