Results 131 to 140 of about 3,030,865 (307)

Tumor‐Derived CDC37 Inhibits Antigen Cross‐Presentation in Dendritic Cells and Impairs Anti‐Tumor Immunity in Breast Cancer

Advanced Science
Tumor mutational burden (TMB), usually representing high immunogenicity, cannot always predict treatment response of immune checkpoint blockade (ICB).
Ruxin Wang, Yunyi Zhang, Xiangyu Meng, Jianli Zhao, Yue Xing, Qian Ouyang, Ning Zhang, Huiping Chen, Nanyan Miao, Erwei Song, Di Huang   +10 more
doaj   +1 more source

IFN-γ and proinflammatory cytokines induce astrocyte programs that support antigen-dependent CD4

Cell Reports
Summary: Astrocyte contributions to CNS antigen presentation remain poorly defined. We show that interferon gamma (IFN-γ, the sole type II interferon), with proinflammatory cytokines, induces astrocytes to express components mediating attraction of and ...
Theodore M. Fisher, Francesco Limone, Matthew D. Smith, Chandler Wright, Petra Kukanja, Peiwen Lu, Kerry C. Limberg, Nicolette Pirjanian, Jimena Zulueta, Valentina Fossati, Akiko Iwasaki, Peter A. Calabresi, Shane A. Liddelow   +12 more
doaj   +1 more source

Antigen presentation in the CNS [PDF]

Molecular Psychiatry, 1997
Frei K, Fontana A
openaire   +3 more sources

Delivery of DNA‐encoded vaccines and proteins in mice using cutaneous suction‐mediated transfection

FEBS Open Bio, EarlyView.
Cutaneous suction‐mediated transfection in mice for delivery of DNA‐encoded vaccines and proteins. A critical limitation of DNA vaccines and other therapeutics is transfection in vivo to produce the encoded antigens or therapeutic proteins. Cutaneous suction‐based methods have demonstrated effectiveness in many animal models and have been successfully ...
Emran O. Lallow, Isabel Brandtjen, Yaxin Mo, Melissa Gulley, Louis Osorio, Sagar Kudchodkar, Nandita C. Jhumur, Christine C. Roberts, Lisa K. Denzin, David I. Shreiber, Biju Parekkadan, Hao Lin, Joel N. Maslow   +12 more
wiley   +1 more source

Protocol for quantifying miRNA trafficking across the endosomal membrane

FEBS Open Bio, EarlyView.
An in vitro protocol measures miRNA uptake into endosomes isolated from mammalian cell extracts, which are free of subcellular contaminants. Performed at 37 °C in the presence of ATP, it ensures the import of single‐stranded miRNA into the endosomal lumen.
Syamantak Ghosh, Kamalika Mukherjee, Suvendra N. Bhattacharyya   +2 more
wiley   +1 more source

The genes related to the antigen processing and presentation pathway.

, 2015
The genes related to the antigen processing and presentation pathway.
Kui Li (48173), Leilei Xin (664368), Siyuan Kong (664369), Shulin Yang (76751), Jihan Xia (664367), Yuanyuan Zhang (101797), Yaoxing Chen (664370)   +6 more
core   +1 more source

BCG vaccination potentiates oxidative phosphorylation in neonatal myeloid‐derived suppressor cells

FEBS Open Bio, EarlyView.
BCG vaccination enhances oxidative phosphorylation in neonatal MDSCs, impairing their immunosuppressive function. It upregulates electron transport chain genes and mitochondrial activity, increasing ATP and oxygen consumption. Pharmacological OXPHOS inhibition partially restores suppressive capacity, confirming causality.
Yingying Chen, Hui Li
wiley   +1 more source

Improved antigen cross-presentation by polyethyleneimine-based nanoparticles

International Journal of Nanomedicine, 2011
Jian Chen1, Zhengrong Li1, Hong Huang2, Yanzhu Yang2, Qian Ding2, Junhua Mai1, Wei Guo2, Yuhong Xu21School of Life Sciences and Biotechnology, 2School of Pharmacy, Shanghai Jiao Tong University, Shanghai, People's Republic of ChinaPurpose: In the
Jian Chen, Zhengrong Li, Hong Huang, et al   +3 more
doaj  

MARK4 enhances stress granule formation under oxidative stress and increases tau accumulation

FEBS Open Bio, EarlyView.
MARK4 (red dots) localizes to stress granules (orange dots) and promotes their formation under oxidative stress by modulating TIA1 (blue dots). MARK4 and TIA1 synergistically increase tau (purple) accumulation, and the reduction of the TIA1 ortholog suppresses neurodegeneration in a fly model.
Sho Nakajima, Kotone Watanabe, Grigorii Sultanakhmetov, Aoi Fukuchi, Keiya Ito, Sawako Shimizu, Taro Saito, Akiko Asada, Kanae Ando   +8 more
wiley   +1 more source

MHCII glycosylation modulates Bacteroides fragilis carbohydrate antigen presentation

, 2011
N-linked glycans are thought to protect class II major histocompatibility complex (MHC) molecules (MHCII) from proteolytic cleavage and assist in arranging proteins within the immune synapse, but were not thought to directly participate in antigen ...
Jason A. Bonomo, Fan Zhao, Sean O. Ryan, Brian A. Cobb   +3 more
core   +1 more source