Antigen presentation by human monocytes: evidence for stimulant processing and requirement for interleukin 1. [PDF]
, 1983 Giuseppe Scala, J J Oppenheim
openalex +1 more source
Classification of acute myeloid leukemia based on multi‐omics and prognosis prediction value
Molecular Oncology, EarlyView.The Unsupervised AML Multi‐Omics Classification System (UAMOCS) integrates genomic, methylation, and transcriptomic data to categorize AML patients into three subtypes (UAMOCS1‐3). This classification reveals clinical relevance, highlighting immune and chromosomal characteristics, prognosis, and therapeutic vulnerabilities.
Yang Song +13 more
wiley +1 more source
Accessory cell stimulation of T cell proliferation requires active antigen processing, Ia-restricted antigen presentation, and a separate nonspecific 2nd signal. [PDF]
, 1981 R N Germain
openalex +1 more source
Antigen presentation by hapten-specific B lymphocytes. I. Role of surface immunoglobulin receptors. [PDF]
, 1984 The present study examines the ability of hapten-specific murine splenic B lymphocytes to present hapten-proteins to carrier-specific T cell hybridomas.
Abbas, AK, Benacerraf, B, Rock, KL
core
Adverse prognosis gene expression patterns in metastatic castration‐resistant prostate cancer
Molecular Oncology, EarlyView.We aggregated a cohort of 1012 mCRPC tissue samples from 769 patients and investigated the association of gene expression‐based pathways with clinical outcomes. Loss of AR signaling, high proliferation, and a glycolytic phenotype were independently prognostic for poor outcomes, and an adverse transcriptional feature score incorporating these pathways ...
Marina N. Sharifi +26 more
wiley +1 more source
An Asymptotic Analysis of Bivalent Monoclonal Antibody-Antigen Binding [PDF]
arXivLigand-receptor interactions are fundamental to many biological processes. For example in antibody-based immunotherapies, the dynamics of an antibody binding with its target antigen directly influence the potency and efficacy of monoclonal antibody (mAb) therapies.
arxiv
Presentation of antigen by B cells: functional dependence on radiation dose, interleukins, cellular activation, and differential glycosylation. [PDF]
, 1985 Michael A. Frohman, Carol Cowing
openalex +1 more source
The Journal of Cell Biology, 2005 Immune cells inspect not just protein but also lipid antigens, thanks to presentation by the MHC relative CD1. Now, results from Peter van den Elzen, Michael Brenner (Harvard Medical School, Boston MA), and colleagues show that immune cells co-opt normal pathways of fat metabolism to deliver ...
openaire +2 more sources
Molecular Oncology, EarlyView.TOMM20 increases cancer aggressiveness by maintaining a reduced state with increased NADH and NADPH levels, oxidative phosphorylation (OXPHOS), and apoptosis resistance while reducing reactive oxygen species (ROS) levels. Conversely, CRISPR‐Cas9 knockdown of TOMM20 alters these cancer‐aggressive traits.
Ranakul Islam +9 more
wiley +1 more source
Antigen presentation by isolated guinea pig Kupffer cells. [PDF]
, 1980 Thomas M. Rogoff, P E Lipsky
openalex +1 more source