Results 151 to 160 of about 3,217,603 (374)

Calcium channel blockers suppress the contact hypersensitivity reaction (CHR) by inhibiting antigen transport and presentation by epidermal Langerhans cells in mice [PDF]

, 1997
Norito Katoh, Shinya Hirano, Saburo Kishimoto, Hirokazu Yasuno   +3 more
openalex   +1 more source

Integrated Immunopeptidomics and Proteomics Study of SARS-CoV-2–Infected Calu-3 Cells Reveals Dynamic Changes in Allele-specific HLA Abundance and Antigen Presentation [PDF]

, 2023
Rui Chen, Kelly M. Fulton, Anh Tran, Diana Duque, Kevin A. Kovalchik, Étienne Caron, Susan M. Twine, Jianjun Li   +7 more
openalex   +1 more source

Indoleamine 2,3‐dioxygenase 1 inhibition reverses cancer‐associated fibroblast‐mediated immunosuppression in high‐grade serous ovarian cancer

FEBS Open Bio, EarlyView.
CAF‐mediated immunosuppression in ovarian cancer is driven by IDO1, reducing T‐cell function. Inhibiting IDO1 restores T‐cell proliferation and cytotoxicity, increases cancer cell apoptosis, and may help overcome CAF‐induced immune suppression in high‐grade serous ovarian cancer. Targeting IDO1 may improve antitumor immunity.
Hyewon Lee, Jung Yoon Ho, In Sun Hwang, Youn Jin Choi   +3 more
wiley   +1 more source

Antigen Presentation Profiling Reveals Recognition of Lymphoma Immunoglobulin Neoantigens

Nature, 2017
Cancer somatic mutations can generate neoantigens that distinguish malignant from normal cells. However, the personalized identification and validation of neoantigens remains a major challenge.
M. Khodadoust, N. Olsson, Lisa E. Wagar, O. Haabeth, Binbin Chen, Kavya Swaminathan, Keith Rawson, C. Liu, D. Steiner, P. Lund, Samhita Rao, Lichao Zhang, C. Marceau, H. Stehr, Aaron M. Newman, D. Czerwinski, V. Carlton, M. Moorhead, M. Faham, H. Kohrt, J. Carette, Michael R. Green, Mark M. Davis, Ronald Levy, Joshua E. Elias, Ash A. Alizadeh   +25 more
semanticscholar   +1 more source

Overexpression of CDT1 inhibits cell cycle progression at S phase by interacting with the mini‐chromosome maintenance complex and causes DNA damage

FEBS Open Bio, EarlyView.
CDT1 is an essential protein for DNA replication licensing that loads the MCM complex, the eukaryotic replicative DNA helicase, onto replication origins. Overexpression of CDT1 induces cell cycle arrest at the S phase. Here we showed CDT1 inhibits the progression of replication forks by interacting with the MCM complex, leading to the stalling and ...
Takashi Tsuyama, Nonoka Takayama, Rina Tanaka, Yuuki Arai, Yohko Yamaguchi, Yuko Nawata, Yutaro Azuma, Shusuke Tada   +7 more
wiley   +1 more source

Nitric oxide mediated inhibition of antigen presentation from DCs to CD4+ T cells in cancer and measurement of STAT1 nitration [PDF]

, 2017
Joseph Markowitz, Jiang Wang, Zach Vangundy, Jia You, Vedat Yildiz, Lianbo Yu, Isaac P. Foote, Owen E. Branson, Andrew Stiff, Taylor Brooks, Brandon J. Biesiadecki, Thomas Olencki, Susheela Tridandapani, Michael A. Freitas, Tracey L. Papenfuss, Mitch A. Phelps, William E. Carson   +16 more
openalex   +1 more source

Overview of molecular signatures of senescence and associated resources: pros and cons

FEBS Open Bio, EarlyView.
Cells can enter a stress response state termed cellular senescence that is involved in various diseases and aging. Detecting these cells is challenging due to the lack of universal biomarkers. This review presents the current state of senescence identification, from biomarkers to molecular signatures, compares tools and approaches, and highlights ...
Orestis A. Ntintas, Sylvia Vagena, Pavlos Pantelis, Giorgos Theocharous, Russel Petty, Konstantinos Evangelou, Vassilis G. Gorgoulis   +6 more
wiley   +1 more source

Posttranscriptional regulation of the components of the human leukocyte antigen class I antigen processing and presentation machinery as an immune escape mechanism in melanoma

, 2021
Maria‐Filothei Lazaridou
openalex   +1 more source

Day/night variations of myeloid and lymphoid cell subsets in the murine inguinal lymph node

FEBS Open Bio, EarlyView.
The circadian system is involved in the temporal regulation of the immune system. Our study reveals that two innate immune populations, NKT cells and neutrophils, predominate at the beginning of the day in healthy mice, highlighting how the time of day influences immune responses.
Paula M. Wagner, César G. Prucca, Lucia Boffelli, Virginia A. Piqueras, Silvia G. Correa, Mariana Maccioni, Mario E. Guido   +6 more
wiley   +1 more source

Modulation of cytomegalovirus immune evasion identifies direct antigen presentation as the predominant mode of CD8 T-cell priming during immune reconstitution after hematopoietic cell transplantation

Frontiers in Immunology
Cytomegalovirus (CMV) infection is the most critical infectious complication in recipients of hematopoietic cell transplantation (HCT) in the period between a therapeutic hematoablative treatment and the hematopoietic reconstitution of the immune system.
Rafaela Holtappels, Julia K. Büttner, Kirsten Freitag, Matthias J. Reddehase, Niels A. Lemmermann, Niels A. Lemmermann   +5 more
doaj   +1 more source