Results 171 to 180 of about 953,664 (316)

HDAC4 regulates apoptosis in Acan‐CreERT2;HDAC4d/d mice with osteoarthritis by downregulating ATF4

FEBS Open Bio, EarlyView.
Using the AcanCreERT2;HDAC4fl/fl genetic mouse model, we further investigated the role of histone deacetylase 4 (HDAC4) in chondrocyte apoptosis. We found that knocking down HDAC4 may be associated with chondrocyte apoptosis by upregulating the activating transcription factor 4 (ATF4)/CAAT/enhancer binding protein homologous (CHOP) signaling pathway ...
Jingrui Huang, Yukun Xu, Yujia Li, Yiming Pang, Xueting Ding, Raorao Zhou, Dan Liang, Xianda Che, Yuanyu Zhang, Chunfang Wang, Wenjin Li, Pengcui Li   +11 more
wiley   +1 more source

Comparison of cell lines deficient in antigen presentation reveals a functional role for TAP-1 alone in antigen processing. [PDF]

, 1994
R. Gabathuler, Gregor S. D. Reid, G Kolaitis, James J. Driscoll, Wilfred A. Jefferies   +4 more
openalex   +1 more source

Beyond digital twins: the role of foundation models in enhancing the interpretability of multiomics modalities in precision medicine

FEBS Open Bio, EarlyView.
This review highlights how foundation models enhance predictive healthcare by integrating advanced digital twin modeling with multiomics and biomedical data. This approach supports disease management, risk assessment, and personalized medicine, with the goal of optimizing health outcomes through adaptive, interpretable digital simulations, accessible ...
Sakhaa Alsaedi, Xin Gao, Takashi Gojobori   +2 more
wiley   +1 more source

LACK OF INFLUENCE OF CYCLOSPORINE ON ANTIGEN PRESENTATION TO LYSOZYME-SPECIFIC T CELL HYBRIDOMAS

, 1988
Simone Müller, Luciano Adorini, Ettore Appella, Zoltan A. Nagy   +3 more
openalex   +1 more source

Antigen presentation by resting B cells. Effectiveness at inducing T cell proliferation is determined by costimulatory signals, not T cell receptor occupancy. [PDF]

, 1990
Marc K. Jenkins, Edwin Burrell, Jonathan D. Ashwell   +2 more
openalex   +1 more source

Hydrogen sulfide repairs testicular damage induced by heat stress in rats

FEBS Open Bio, EarlyView.
Heat stress can cause testicular damage and affect fertility. We investigated the potential protective role of hydrogen sulfide (H2S) against heat stress‐induced testicular injury and observed that H2S donor NaHS can effectively restore testicular damage in rats by inhibiting inflammation and oxidative stress. Our results suggest that H2S might be used
Xinyu Guo, Yupeng Yin, Susu Guo, Xiaoyan Chen, Suyan Xie, Shiqin Chen, Yan Huang   +6 more
wiley   +1 more source

Antigen Presentation by Extracellular Vesicles in the Acute Phase of Corneal Transplantation. [PDF]

Invest Ophthalmol Vis Sci
Shimizu T, Hayashi T, Kurita J, Yuda K, Mizuki N, Yamagami S.   +5 more
europepmc   +1 more source

Dysfunctional tetraspanin 7 (TSP‐7) in Caenorhabditis elegans promotes; increases in average life‐ & health‐span, stress‐induced survival and motility

FEBS Open Bio, EarlyView.
The C. elegans tetraspanin‐7 (tsp‐7) is a homologue of human CD63, which is a negative regulator of autophagy. The C. elegans strain, tm5761, has a dysfunctional (knockout) tsp‐7 gene. When compared to the wild‐type strain, the tm5761 strain shows increased: life‐ and health‐span; thermotolerance, and stress‐induced locomotion.
Brogan Jones, Laurence Seabra, Francesco Michelangeli   +2 more
wiley   +1 more source

Editorial: Antigen presentation in cancer immune responses. [PDF]

Front Immunol
Asselin-Labat ML, Ruhland MK, Ferris ST.
europepmc   +1 more source

New insights suggesting a possible role of a heat shock protein 70-kD family-related protein in antigen processing/presentation phenomenon in humans [PDF]

, 1993
GC Manara, Paolo Sansoni, L. Badiali‐De Giorgi, Giorgio Gallinella, Carlo Ferrari, Vincenzo Brianti, F F Fagnoni, CL Ruegg, Giuseppe De Panfilis, Gianandrea Pasquinelli   +9 more
openalex   +1 more source