Results 51 to 60 of about 3,243,106 (373)

Endo-lysosomal assembly variations among human leukocyte antigen class I (HLA class I) allotypes

eLife, 2023
The extreme polymorphisms of human leukocyte antigen class I (HLA class I) proteins enable the presentation of diverse peptides to cytotoxic T lymphocytes.
Eli Olson, Theadora Ceccarelli, Malini Raghavan   +2 more
doaj   +1 more source

Major Histocompatibility Complex (MHC) Class I and MHC Class II Proteins: Conformational Plasticity in Antigen Presentation

Frontiers in Immunology, 2017
Antigen presentation by major histocompatibility complex (MHC) proteins is essential for adaptive immunity. Prior to presentation, peptides need to be generated from proteins that are either produced by the cell’s own translational machinery or that are ...
M. Wieczorek, Esam T. Abualrous, J. Sticht, Miguel Álvaro-Benito, Sebastian Stolzenberg, F. Noé, C. Freund   +6 more
semanticscholar   +1 more source

Cytomegalovirus prevents antigen presentation by blocking the transport of peptide-loaded major histocompatibility complex class I molecules into the medial-Golgi compartment [PDF]

, 1992
Selective expression of murine cytomegalovirus (MCMV) immediate-early (IE) genes leads to the presentation by the major histocompatibility complex (MHC) class I molecule L a of a peptide derived from MCMV IE protein pp89 (Reddehase, M. J., J.
Del Val, Margarita, Hartlaub, Udo, Hengel, Hartmut, Häcker, Hans, Koszinowski, Ulrich H., Lucin, Pero, Ruppert, Thomas   +6 more
core   +2 more sources

Efficient Capsid Antigen Presentation From Adeno-Associated Virus Empty Virions In Vivo

Frontiers in Immunology, 2018
Adeno-associated virus (AAV) vectors have been successfully applied in clinical trials for hemophilic patients. Although promising, the clinical results suggest that the capsid-specific CD8+T cell response has a negative effect on therapeutic success. In
Xiaolei Pei, Xiaolei Pei, Lauriel Freya Earley, Yi He, Yi He, Xiaojing Chen, Nikita Elexa Hall, Richard Jude Samulski, Richard Jude Samulski, Chengwen Li, Chengwen Li   +10 more
doaj   +1 more source

Resistance to checkpoint blockade therapy through inactivation of antigen presentation

Nature Communications, 2017
Treatment with immune checkpoint blockade (CPB) therapies often leads to prolonged responses in patients with metastatic melanoma, but the common mechanisms of primary and acquired resistance to these agents remain incompletely characterized and have yet
Moshe Sade-Feldman, Yunxin J. Jiao, Jonathan H. Chen, Michael S. Rooney, Michal Barzily-Rokni, J. Eliane, Stacey L. Bjorgaard, Marc R. Hammond, Hans Vitzthum, S. Blackmon, Dennie T. Frederick, M. Hazar-Rethinam, Brandon Nadres, Emily E. Van Seventer, S. Shukla, Keren Yizhak, John P. Ray, D. Rosebrock, D. Livitz, V. Adalsteinsson, G. Getz, L. Duncan, Bo Li, R. Corcoran, D. Lawrence, A. Stemmer-Rachamimov, G. Boland, D. Landau, K. Flaherty, R. Sullivan, N. Hacohen   +30 more
semanticscholar   +1 more source

Assessment of In Vitro Immunostimulatory Activity of an Adjuvanted Whole-Cell Inactivated Neisseria gonorrhoeae Microparticle Vaccine Formulation

Vaccines, 2022
The emergence of drug-resistant gonorrhea infections worldwide combined with the lack of a vaccine is alarming. We prepared a novel microparticulate (MP) vaccine formulation using whole-cell inactivated Neisseria gonorrhoeae as the vaccine antigen, with ...
Priyal Bagwe, Lotika Bajaj, Rikhav P. Gala, Martin J. D‘Souza, Susu M. Zughaier   +4 more
doaj   +1 more source

Vaccine delivery by penetratin: mechanism of antigen presentation by dendritic cells [PDF]

, 2016
Cell-penetrating peptides (CPP) or membrane-translocating peptides such as penetratin from Antennapedia homeodomain or TAT from human immunodeficiency virus are useful vectors for the delivery of protein antigens or their cytotoxic (Tc) or helper (Th) T ...
A Lenarczyk, BC Gil-Torregrosa, BP Gross, C Bechara, C Jacobs, CC Norbury, CC Norbury, Choon-Kit Tang, CM Fehres, Dodie Pouniotis, DS Pouniotis, DS Pouniotis, DT Kim, E Koren, E Vives, F Wang, G Fenteany, GA Pietersz, Geoffrey Pietersz, GG Chikh, H Umezawa, H Yang, HY Wang, I Melero, I Mellman, J Chen, J Lu, J Lu, J Pohl, JC Mai, JE Schnitzer, JP Richard, JS Blum, JS Park, K Palucka, KC Sheng, L Cohn, L Delamarre, LJ Cruz, M Kovacsovics-Bankowski, M Mansourian, MA Morse, MA West, MM Fretz, MP Schutze-Redelmeier, MP Schutze-Redelmeier, MV Dhodapkar, N Brooks, N Merzougui, N Shibagaki, NA Brooks, NA Brooks, OP Joffre, P Midoux, P Sampath, PA Orlandi, PJ Tacken, R Wallbrecher, S Kozlowski, S Sanderson, S Vassilaros, SM Farkhani, T Buhl, T Wileman, TB Potocky, V Apostolopoulos, V Apostolopoulos, V Apostolopoulos, Vasso Apostolopoulos, W Kastenmuller, WF Lo, X Wu, Y Cho, Y Jiang, Z Yang   +74 more
core   +1 more source

Immunogens and Antigen Processing: Report from a Global HIV Vaccine Enterprise Working Group [PDF]

, 2010
The Global HIV Vaccine Enterprise convened a meeting of a Working Group in July 2009 to discuss recent progress in rational design of the components of an HIV vaccine, such as inserts, vectors and adjuvants,and in understanding antigen processing and ...
John Mascola, Ralph Steinman, Richter C. King, the Working Group convened by the Global HIV Vaccine Enterprise   +3 more
core   +3 more sources

Improved Outcomes for Older Children, Adolescents, and Young Adults With Neuroblastoma in the Post‐Immunotherapy Era: An Updated Report From the International Neuroblastoma Risk Group

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background We describe clinical and biologic characteristics of neuroblastoma in older children, adolescents, and young adults (OCAYA); describe survival outcomes in the post‐immunotherapy era; and identify if there is an age cut‐off that best discriminates outcomes.
Rebecca J. Deyell, Kavitha Srivatsa, Paola Angelini, Pei‐Chi Kao, Brady Payne, Arlene Naranjo, Sveva Castelli, Miho Kato, Miki Ohira, Ulriche Pöetschger, Yaël Mossé, Lucas Moreno, Meredith S. Irwin, Ramya Ramanujachar, Wendy B. London   +14 more
wiley   +1 more source

Supplementary Data from Rebalancing Protein Homeostasis Enhances Tumor Antigen Presentation

, 2023
Alex M. Jaeger, Lauren Stopfer, Sunmin Lee, Giorgio Gaglia, Demi Sandel, Sandro Santagata, Nancy U. Lin, Jane B. Trepel, Forest M. White, Tyler Jacks, Susan Lindquist, Luke Whitesell   +11 more
  +4 more sources