Results 51 to 60 of about 3,217,603 (374)

Cytomegalovirus prevents antigen presentation by blocking the transport of peptide-loaded major histocompatibility complex class I molecules into the medial-Golgi compartment [PDF]

, 1992
Selective expression of murine cytomegalovirus (MCMV) immediate-early (IE) genes leads to the presentation by the major histocompatibility complex (MHC) class I molecule L a of a peptide derived from MCMV IE protein pp89 (Reddehase, M. J., J.
Del Val, Margarita, Hartlaub, Udo, Hengel, Hartmut, Häcker, Hans, Koszinowski, Ulrich H., Lucin, Pero, Ruppert, Thomas   +6 more
core   +2 more sources

A novel HLA-B18 restricted CD8+ T cell epitope is efficiently cross-presented by dendritic cells from soluble tumor antigen [PDF]

, 2012
NY-ESO-1 has been a major target of many immunotherapy trials because it is expressed by various cancers and is highly immunogenic. In this study, we have identified a novel HLA-B*1801-restricted CD8⁺T cell epitope, NY-ESO-1<sub&
Ashley J. Knights, Emmanuel Scotet, Eugene Maraskovsky, Heather M. Jackson, Ian D. Davis, Immanuel F. Luescher, Jonathan Cebon, Kok-Fei Chan, Kun Xiao, Neil C. Robson, Nektaria Dimopoulos, Nicole A. Mifsud, Philippe Guillaume, Rona Y. Zhao, Sara Oveissi, Sarah E. Russell, Sylvie Le Gall, Tamara Lowen, Weisan Chen   +18 more
core   +10 more sources

Antigen presentation by MHC-dressed cells

Frontiers in Immunology, 2015
Professional antigen presenting cells (APCs) such as conventional dendritic cells (DCs) process protein antigens to MHC-bound peptides and then present the peptide-MHC complexes to T cells.
Masafumi eNakayama
doaj   +1 more source

Vaccine delivery by penetratin: mechanism of antigen presentation by dendritic cells [PDF]

, 2016
Cell-penetrating peptides (CPP) or membrane-translocating peptides such as penetratin from Antennapedia homeodomain or TAT from human immunodeficiency virus are useful vectors for the delivery of protein antigens or their cytotoxic (Tc) or helper (Th) T ...
A Lenarczyk, BC Gil-Torregrosa, BP Gross, C Bechara, C Jacobs, CC Norbury, CC Norbury, Choon-Kit Tang, CM Fehres, Dodie Pouniotis, DS Pouniotis, DS Pouniotis, DT Kim, E Koren, E Vives, F Wang, G Fenteany, GA Pietersz, Geoffrey Pietersz, GG Chikh, H Umezawa, H Yang, HY Wang, I Melero, I Mellman, J Chen, J Lu, J Lu, J Pohl, JC Mai, JE Schnitzer, JP Richard, JS Blum, JS Park, K Palucka, KC Sheng, L Cohn, L Delamarre, LJ Cruz, M Kovacsovics-Bankowski, M Mansourian, MA Morse, MA West, MM Fretz, MP Schutze-Redelmeier, MP Schutze-Redelmeier, MV Dhodapkar, N Brooks, N Merzougui, N Shibagaki, NA Brooks, NA Brooks, OP Joffre, P Midoux, P Sampath, PA Orlandi, PJ Tacken, R Wallbrecher, S Kozlowski, S Sanderson, S Vassilaros, SM Farkhani, T Buhl, T Wileman, TB Potocky, V Apostolopoulos, V Apostolopoulos, V Apostolopoulos, Vasso Apostolopoulos, W Kastenmuller, WF Lo, X Wu, Y Cho, Y Jiang, Z Yang   +74 more
core   +1 more source

Presentation of hepatocellular antigens [PDF]

Cellular & Molecular Immunology, 2016
The liver is an organ in which antigen-specific T-cell responses manifest a bias toward immune tolerance. This is clearly seen in the rejection of allogeneic liver transplants, and multiple other phenomena suggest that this effect is more general.
Grakoui, Arash, Crispe, Ian Nicholas
openaire   +2 more sources

Heat Shock Protein Magic in Antigen Trafficking within Dendritic Cells:Implications in Antigen Cross-presentation in Immunity [PDF]

, 2012
Dendritic cells (DCs) take up soluble- or cell-associated antigens and digest them, delivering fragments to the MHC class I pathway to display antigenic peptides to CD8＋ T cells, a process known as cross-presentation.
Udono, Heiichiro
core   +1 more source

Making Antigen Presentable [PDF]

The Journal of Immunology, 2007
In the late 1960s and early 1970s, a shift occurred in the focus of immunological research from Ab-dominated studies to ones involving cellular components of immunity such as T cells, B cells, and APCs.
openaire   +2 more sources

Assessment of In Vitro Immunostimulatory Activity of an Adjuvanted Whole-Cell Inactivated Neisseria gonorrhoeae Microparticle Vaccine Formulation

Vaccines, 2022
The emergence of drug-resistant gonorrhea infections worldwide combined with the lack of a vaccine is alarming. We prepared a novel microparticulate (MP) vaccine formulation using whole-cell inactivated Neisseria gonorrhoeae as the vaccine antigen, with ...
Priyal Bagwe, Lotika Bajaj, Rikhav P. Gala, Martin J. D‘Souza, Susu M. Zughaier   +4 more
doaj   +1 more source

Major Histocompatibility Complex (MHC) Class I and MHC Class II Proteins: Conformational Plasticity in Antigen Presentation

Frontiers in Immunology, 2017
Antigen presentation by major histocompatibility complex (MHC) proteins is essential for adaptive immunity. Prior to presentation, peptides need to be generated from proteins that are either produced by the cell’s own translational machinery or that are ...
M. Wieczorek, Esam T. Abualrous, J. Sticht, Miguel Álvaro-Benito, Sebastian Stolzenberg, F. Noé, C. Freund   +6 more
semanticscholar   +1 more source

Fc Gamma Receptors and Their Role in Antigen Uptake, Presentation, and T Cell Activation

Frontiers in Immunology, 2020
The cellular uptake, intracellular processing, and presentation of foreign antigen are crucial processes for eliciting an effective adaptive host response to the majority of pathogens.
F. Junker, J. Gordon, O. Qureshi
semanticscholar   +1 more source