Results 51 to 60 of about 3,313,044 (282)

Antigen processing and remodeling of the endosomal pathway: requirements for antigen cross-presentation.

Frontiers in Immunology, 2012
The cross-presentation of endocytosed antigen as peptide/class I MHC complexes plays a central role in the elicitation of CD8+ T cell clones that mediate anti-viral and anti-tumor immune responses.
Ewoud Bernardus Compeer, Thijs Willem Hendrik Flinsenberg, Susanna Geertje van der Grein, Marianne eBoes   +3 more
doaj   +1 more source

Fc Gamma Receptors and Their Role in Antigen Uptake, Presentation, and T Cell Activation

Frontiers in Immunology, 2020
The cellular uptake, intracellular processing, and presentation of foreign antigen are crucial processes for eliciting an effective adaptive host response to the majority of pathogens.
F. Junker, J. Gordon, O. Qureshi
semanticscholar   +1 more source

An upstream open reading frame regulates expression of the mitochondrial protein Slm35 and mitophagy flux

FEBS Letters, EarlyView.
This study reveals how the mitochondrial protein Slm35 is regulated in Saccharomyces cerevisiae. The authors identify stress‐responsive DNA elements and two upstream open reading frames (uORFs) in the 5′ untranslated region of SLM35. One uORF restricts translation, and its mutation increases Slm35 protein levels and mitophagy.
Hernán Romo‐Casanueva, Ariann E. Mendoza‐Martínez, P. Abril Medina‐Flores, Carlos Campero‐Basaldua, Alexander DeLuna, Soledad Funes   +5 more
wiley   +1 more source

Effects of MicroRNA on Regulatory T Cells and Implications for Adoptive Cellular Therapy to Ameliorate Graft-versus-Host Disease

Frontiers in Immunology, 2018
Regulatory T cells (Tregs) are key mediators of the immune system. MicroRNAs (miRNAs) are a family of ~22 nucleotide non-coding RNAs that are processed from longer precursors by the RNases Drosha and Dicer.
Keli L. Hippen, Michael Loschi, Jemma Nicholls, Kelli P. A. MacDonald, Bruce R. Blazar   +4 more
doaj   +1 more source

Targeting EZH2 Enhances Antigen Presentation, Antitumor Immunity, and Circumvents Anti–PD-1 Resistance in Head and Neck Cancer

Clinical Cancer Research, 2019
Purpose: Anti–programmed death-1 (PD-1) receptor–based therapeutics improve survival in patients with recurrent head and neck squamous cell carcinoma (HNSCC), but many do not benefit due to a low response rate. Herein, we identified EZH2 as a therapeutic
Liye Zhou, Tenny Mudianto, Xiaojing Ma, R. Riley, R. Uppaluri   +4 more
semanticscholar   +1 more source

Inhibiting stearoyl‐CoA desaturase suppresses bone metastatic prostate cancer by modulating cellular stress, mTOR signaling, and DNA damage response

FEBS Letters, EarlyView.
Bone metastasis in prostate cancer (PCa) patients is a clinical hurdle due to the poor understanding of the supportive bone microenvironment. Here, we identify stearoyl‐CoA desaturase (SCD) as a tumor‐promoting enzyme and potential therapeutic target in bone metastatic PCa.
Alexis Wilson, Mackenzie K Herroon, Shane Mecca, Laimar C Garmo, Jacob Lindquist, Shrila Rajendran, Steve M. Patrick, Izabela Podgorski   +7 more
wiley   +1 more source

Nanoscale Metal-organic Frameworks Mediate Photodynamic Therapy and Deliver CpG Oligodeoxynucleotides to Enhance Antigen Presentation and Cancer Immunotherapy.

Angewandte Chemie, 2019
Checkpoint blockade immunotherapy (CBI) awakes host innate immune system and reactivates cytotoxic T cells to elicit durable response in some cancer patients.
Kaiyuan Ni, Taokun Luo, Guangxu Lan, August Culbert, Yang Song, Tong Wu, Xiaomin Jiang, Wenbin Lin   +7 more
semanticscholar   +1 more source

Structural biology of ferritin nanocages

FEBS Letters, EarlyView.
Ferritin is a conserved iron‐storage protein that sequesters iron as a ferric mineral core within a nanocage, protecting cells from oxidative damage and maintaining iron homeostasis. This review discusses ferritin biology, structure, and function, and highlights recent cryo‐EM studies revealing mechanisms of ferritinophagy, cellular iron uptake, and ...
Eloise Mastrangelo, Flavio Di Pisa
wiley   +1 more source

Oncogenic LncRNA downregulates cancer cell antigen presentation and intrinsic tumor suppression

Nature Immunology, 2019
How tumor cells genetically lose antigenicity and evade immune checkpoints remains largely elusive. We report that tissue-specific expression of the human long noncoding RNA LINK-A in mouse mammary glands initiates metastatic mammary gland tumors, which ...
Qingsong Hu, Youqiong Ye, Li-Chuan Chan, Yajuan Li, K. Liang, Aifu Lin, Sergey D Egranov, Yaohua Zhang, W. Xia, Jing Gong, Yinghong Pan, Sujash S. Chatterjee, Jun Yao, K. Evans, Tina K. Nguyen, P. K. Park, Jiewei Liu, C. Coarfa, Sri Ramya Donepudi, V. Putluri, N. Putluri, A. Sreekumar, Chandrashekar R. Ambati, D. Hawke, J. Marks, P. Gunaratne, A. Caudle, A. Sahin, G. Hortobagyi, F. Meric-Bernstam, Lieping Chen, Dihua Yu, M. Hung, M. Curran, Leng Han, Chunru Lin, Liuqing Yang   +36 more
semanticscholar   +1 more source

Mechanisms of IgE‐mediated food allergy and the role of allergen‐specific B cells

FEBS Letters, EarlyView.
Food allergy arises when allergen‐specific B cells preferentially produce immunoglobulin E (IgE) antibodies against harmless foods. This article explains the mechanisms driving IgE‐mediated reactions, highlights the central role of these B cells, and discusses how natural tolerance (NT) and oral immunotherapy (OIT) can reshape allergic immune responses.
Juan‐Felipe López, Özge Yilmaz Ardicli, Mübeccel Akdis   +2 more
wiley   +1 more source